Causal Effects of Serum Levels of n-3 or n-6 Polyunsaturated Fatty Acids on Coronary Artery Disease: Mendelian Randomization Study
We aimed to investigate the causal effects of n-3 and n-6 polyunsaturated fatty acids (PUFAs) on the risk of coronary artery disease (CAD) through Mendelian randomization (MR) analysis. This MR study utilized a genetic instrument developed from previous genome-wide association studies for various se...
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MDPI AG
2021-04-01
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| Online Access: | https://www.mdpi.com/2072-6643/13/5/1490 |
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| author | Sehoon Park Soojin Lee Yaerim Kim Yeonhee Lee Min Woo Kang Kwangsoo Kim Yong Chul Kim Seung Seok Han Hajeong Lee Jung Pyo Lee Kwon Wook Joo Chun Soo Lim Yon Su Kim Dong Ki Kim |
| author_facet | Sehoon Park Soojin Lee Yaerim Kim Yeonhee Lee Min Woo Kang Kwangsoo Kim Yong Chul Kim Seung Seok Han Hajeong Lee Jung Pyo Lee Kwon Wook Joo Chun Soo Lim Yon Su Kim Dong Ki Kim |
| author_sort | Sehoon Park |
| collection | DOAJ |
| description | We aimed to investigate the causal effects of n-3 and n-6 polyunsaturated fatty acids (PUFAs) on the risk of coronary artery disease (CAD) through Mendelian randomization (MR) analysis. This MR study utilized a genetic instrument developed from previous genome-wide association studies for various serum n-3 and n-6 PUFA levels. First, we calculated the allele scores for genetic predisposition of PUFAs in individuals of European ancestry in the UK Biobank data (<i>N</i> = 337,129). The allele score-based MR was obtained by regressing the allele scores to CAD risks. Second, summary-level MR was performed with the CARDIoGRAMplusC4D data for CAD (<i>N</i> = 184,305). Higher genetically predicted eicosapentaenoic acid and dihomo-gamma-linolenic acid levels were significantly associated with a lower risk of CAD both in the allele-score-based and summary-level MR analyses. Higher allele scores for linoleic acid level were significantly associated with lower CAD risks, and in the summary-level MR, the causal estimates by the pleiotropy-robust MR methods also indicated that higher linoleic acid levels cause a lower risk of CAD. Arachidonic acid showed significant causal estimates for a higher risk of CAD. This study supports the causal effects of certain n-3 and n-6 PUFA types on the risk of CAD. |
| first_indexed | 2024-03-10T11:52:40Z |
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| id | doaj.art-02fa15eae2e8467aa7331d82916395ce |
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| language | English |
| last_indexed | 2024-03-10T11:52:40Z |
| publishDate | 2021-04-01 |
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| series | Nutrients |
| spelling | doaj.art-02fa15eae2e8467aa7331d82916395ce2023-11-21T17:33:28ZengMDPI AGNutrients2072-66432021-04-01135149010.3390/nu13051490Causal Effects of Serum Levels of n-3 or n-6 Polyunsaturated Fatty Acids on Coronary Artery Disease: Mendelian Randomization StudySehoon Park0Soojin Lee1Yaerim Kim2Yeonhee Lee3Min Woo Kang4Kwangsoo Kim5Yong Chul Kim6Seung Seok Han7Hajeong Lee8Jung Pyo Lee9Kwon Wook Joo10Chun Soo Lim11Yon Su Kim12Dong Ki Kim13Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul 03080, KoreaDivision of Nephrology, Department of Internal Medicine, Uijeongbu Eulji University Medical Center, Uijeongbu 11759, Gyeonggi-do, KoreaDepartment of Internal Medicine, Keimyung University School of Medicine, Daegu 42601, KoreaDivision of Nephrology, Department of Internal Medicine, Uijeongbu Eulji University Medical Center, Uijeongbu 11759, Gyeonggi-do, KoreaDepartment of Internal Medicine, Seoul National University Hospital, Seoul 03080, KoreaTransdisciplinary Department of Medicine & Advanced Technology, Seoul National University Hospital, Seoul 03080, KoreaDepartment of Internal Medicine, Seoul National University Hospital, Seoul 03080, KoreaDepartment of Internal Medicine, Seoul National University Hospital, Seoul 03080, KoreaDepartment of Internal Medicine, Seoul National University Hospital, Seoul 03080, KoreaDepartment of Internal Medicine, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul 03080, KoreaDepartment of Internal Medicine, Seoul National University Hospital, Seoul 03080, KoreaDepartment of Internal Medicine, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul 03080, KoreaDepartment of Biomedical Sciences, Seoul National University College of Medicine, Seoul 03080, KoreaDepartment of Internal Medicine, Seoul National University Hospital, Seoul 03080, KoreaWe aimed to investigate the causal effects of n-3 and n-6 polyunsaturated fatty acids (PUFAs) on the risk of coronary artery disease (CAD) through Mendelian randomization (MR) analysis. This MR study utilized a genetic instrument developed from previous genome-wide association studies for various serum n-3 and n-6 PUFA levels. First, we calculated the allele scores for genetic predisposition of PUFAs in individuals of European ancestry in the UK Biobank data (<i>N</i> = 337,129). The allele score-based MR was obtained by regressing the allele scores to CAD risks. Second, summary-level MR was performed with the CARDIoGRAMplusC4D data for CAD (<i>N</i> = 184,305). Higher genetically predicted eicosapentaenoic acid and dihomo-gamma-linolenic acid levels were significantly associated with a lower risk of CAD both in the allele-score-based and summary-level MR analyses. Higher allele scores for linoleic acid level were significantly associated with lower CAD risks, and in the summary-level MR, the causal estimates by the pleiotropy-robust MR methods also indicated that higher linoleic acid levels cause a lower risk of CAD. Arachidonic acid showed significant causal estimates for a higher risk of CAD. This study supports the causal effects of certain n-3 and n-6 PUFA types on the risk of CAD.https://www.mdpi.com/2072-6643/13/5/1490coronary artery diseasemendelian randomizationpolyunsaturated fatty acidsmyocardial infarctionrisk factor |
| spellingShingle | Sehoon Park Soojin Lee Yaerim Kim Yeonhee Lee Min Woo Kang Kwangsoo Kim Yong Chul Kim Seung Seok Han Hajeong Lee Jung Pyo Lee Kwon Wook Joo Chun Soo Lim Yon Su Kim Dong Ki Kim Causal Effects of Serum Levels of n-3 or n-6 Polyunsaturated Fatty Acids on Coronary Artery Disease: Mendelian Randomization Study Nutrients coronary artery disease mendelian randomization polyunsaturated fatty acids myocardial infarction risk factor |
| title | Causal Effects of Serum Levels of n-3 or n-6 Polyunsaturated Fatty Acids on Coronary Artery Disease: Mendelian Randomization Study |
| title_full | Causal Effects of Serum Levels of n-3 or n-6 Polyunsaturated Fatty Acids on Coronary Artery Disease: Mendelian Randomization Study |
| title_fullStr | Causal Effects of Serum Levels of n-3 or n-6 Polyunsaturated Fatty Acids on Coronary Artery Disease: Mendelian Randomization Study |
| title_full_unstemmed | Causal Effects of Serum Levels of n-3 or n-6 Polyunsaturated Fatty Acids on Coronary Artery Disease: Mendelian Randomization Study |
| title_short | Causal Effects of Serum Levels of n-3 or n-6 Polyunsaturated Fatty Acids on Coronary Artery Disease: Mendelian Randomization Study |
| title_sort | causal effects of serum levels of n 3 or n 6 polyunsaturated fatty acids on coronary artery disease mendelian randomization study |
| topic | coronary artery disease mendelian randomization polyunsaturated fatty acids myocardial infarction risk factor |
| url | https://www.mdpi.com/2072-6643/13/5/1490 |
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