Macrophage colony-stimulating factor and its role in the tumor microenvironment: novel therapeutic avenues and mechanistic insights
The tumor microenvironment is a complex ecosystem where various cellular and molecular interactions shape the course of cancer progression. Macrophage colony-stimulating factor (M-CSF) plays a pivotal role in this context. This study delves into the biological properties and functions of M-CSF in re...
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2024-04-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2024.1358750/full |
| _version_ | 1797224309414952960 |
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| author | Li Yi Yihan Gai Zhuo Chen Kecan Tian Pengfei Liu Hongrui Liang Xinyu Xu Qiuyi Peng Xiaoqing Luo |
| author_facet | Li Yi Yihan Gai Zhuo Chen Kecan Tian Pengfei Liu Hongrui Liang Xinyu Xu Qiuyi Peng Xiaoqing Luo |
| author_sort | Li Yi |
| collection | DOAJ |
| description | The tumor microenvironment is a complex ecosystem where various cellular and molecular interactions shape the course of cancer progression. Macrophage colony-stimulating factor (M-CSF) plays a pivotal role in this context. This study delves into the biological properties and functions of M-CSF in regulating tumor-associated macrophages (TAMs) and its role in modulating host immune responses. Through the specific binding to its receptor colony-stimulating factor 1 receptor (CSF-1R), M-CSF orchestrates a cascade of downstream signaling pathways to modulate macrophage activation, polarization, and proliferation. Furthermore, M-CSF extends its influence to other immune cell populations, including dendritic cells. Notably, the heightened expression of M-CSF within the tumor microenvironment is often associated with dismal patient prognoses. Therefore, a comprehensive investigation into the roles of M-CSF in tumor growth advances our comprehension of tumor development mechanisms and unveils promising novel strategies and approaches for cancer treatment. |
| first_indexed | 2024-04-24T13:51:04Z |
| format | Article |
| id | doaj.art-02fa60500fb649d98c7b263d6ffa0da6 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-24T13:51:04Z |
| publishDate | 2024-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-02fa60500fb649d98c7b263d6ffa0da62024-04-04T04:37:38ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2024-04-011410.3389/fonc.2024.13587501358750Macrophage colony-stimulating factor and its role in the tumor microenvironment: novel therapeutic avenues and mechanistic insightsLi Yi0Yihan Gai1Zhuo Chen2Kecan Tian3Pengfei Liu4Hongrui Liang5Xinyu Xu6Qiuyi Peng7Xiaoqing Luo8Medical Technology College of Qiqihar Medical College, Qiqihar, Heilongjiang, ChinaSchool of Stomatology, Qiqihar Medical College, Qiqihar, Heilongjiang, ChinaMedical Technology College of Qiqihar Medical College, Qiqihar, Heilongjiang, ChinaMedical Technology College of Qiqihar Medical College, Qiqihar, Heilongjiang, ChinaSchool of Basic Medical Sciences, Qiqihar Medical College, Qiqihar, Heilongjiang, ChinaSchool of Basic Medical Sciences, Qiqihar Medical College, Qiqihar, Heilongjiang, ChinaMedical Technology College of Qiqihar Medical College, Qiqihar, Heilongjiang, ChinaSchool of Basic Medical Sciences, Qiqihar Medical College, Qiqihar, Heilongjiang, ChinaMedical Technology College of Qiqihar Medical College, Qiqihar, Heilongjiang, ChinaThe tumor microenvironment is a complex ecosystem where various cellular and molecular interactions shape the course of cancer progression. Macrophage colony-stimulating factor (M-CSF) plays a pivotal role in this context. This study delves into the biological properties and functions of M-CSF in regulating tumor-associated macrophages (TAMs) and its role in modulating host immune responses. Through the specific binding to its receptor colony-stimulating factor 1 receptor (CSF-1R), M-CSF orchestrates a cascade of downstream signaling pathways to modulate macrophage activation, polarization, and proliferation. Furthermore, M-CSF extends its influence to other immune cell populations, including dendritic cells. Notably, the heightened expression of M-CSF within the tumor microenvironment is often associated with dismal patient prognoses. Therefore, a comprehensive investigation into the roles of M-CSF in tumor growth advances our comprehension of tumor development mechanisms and unveils promising novel strategies and approaches for cancer treatment.https://www.frontiersin.org/articles/10.3389/fonc.2024.1358750/fullmacrophage colony-stimulating factortumor progressionCSF-1Rimmune modulationdendritic cellscancer therapy |
| spellingShingle | Li Yi Yihan Gai Zhuo Chen Kecan Tian Pengfei Liu Hongrui Liang Xinyu Xu Qiuyi Peng Xiaoqing Luo Macrophage colony-stimulating factor and its role in the tumor microenvironment: novel therapeutic avenues and mechanistic insights Frontiers in Oncology macrophage colony-stimulating factor tumor progression CSF-1R immune modulation dendritic cells cancer therapy |
| title | Macrophage colony-stimulating factor and its role in the tumor microenvironment: novel therapeutic avenues and mechanistic insights |
| title_full | Macrophage colony-stimulating factor and its role in the tumor microenvironment: novel therapeutic avenues and mechanistic insights |
| title_fullStr | Macrophage colony-stimulating factor and its role in the tumor microenvironment: novel therapeutic avenues and mechanistic insights |
| title_full_unstemmed | Macrophage colony-stimulating factor and its role in the tumor microenvironment: novel therapeutic avenues and mechanistic insights |
| title_short | Macrophage colony-stimulating factor and its role in the tumor microenvironment: novel therapeutic avenues and mechanistic insights |
| title_sort | macrophage colony stimulating factor and its role in the tumor microenvironment novel therapeutic avenues and mechanistic insights |
| topic | macrophage colony-stimulating factor tumor progression CSF-1R immune modulation dendritic cells cancer therapy |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2024.1358750/full |
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