Epidemiology, genetic characteristics, and association with meteorological factors of human metapneumovirus infection in children in southern China: A 10-year retrospective study
Objectives: This study aimed to determine the epidemiological and genetic features of human metapneumovirus (HMPV) infection in children in southern China, and the effect of meteorological factors on infection. Methods: 14,817 children (≤14 years) with acute respiratory tract infections from 2010 to...
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| Format: | Article |
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Elsevier
2023-12-01
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| Series: | International Journal of Infectious Diseases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971223007397 |
| _version_ | 1797435783163936768 |
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| author | Hengming Ye Shuqing Zhang Kexin Zhang Yizhe Li Delin Chen Yongyao Tan Linyue Liang Minjie Liu Jingyao Liang Shu An Jueheng Wu Xun Zhu Mengfeng Li Zhenjian He |
| author_facet | Hengming Ye Shuqing Zhang Kexin Zhang Yizhe Li Delin Chen Yongyao Tan Linyue Liang Minjie Liu Jingyao Liang Shu An Jueheng Wu Xun Zhu Mengfeng Li Zhenjian He |
| author_sort | Hengming Ye |
| collection | DOAJ |
| description | Objectives: This study aimed to determine the epidemiological and genetic features of human metapneumovirus (HMPV) infection in children in southern China, and the effect of meteorological factors on infection. Methods: 14,817 children (≤14 years) with acute respiratory tract infections from 2010 to 2019 were examined for HMPV and other respiratory viruses by real-time quantitative polymerase chain reaction. Full-length F gene of 54 positive samples were sequenced and subjected to phylogenetic analysis. The correlation between the HMPV-positive rate and meteorological factors was analyzed by linear regression analysis. Results: HMPV was detected in 524 (3.5%) children, who were mostly younger than 1 year. The seasonal peak of HMPV prevalence mainly occurred in spring. Respiratory syncytial virus was the most common virus coinfected with HMPV (5.3%). Phylogenetic analysis revealed that the sequenced HMPV strains belonged to four sublineages, including A2b (1.9%), A2c (31.5%), B1 (50.0%), and B2 (16.7%). After adjusting for all meteorological factors, sunshine duration was inversely correlated with the HMPV-positive rate. Conclusion: HMPV is an important respiratory pathogen that causes acute respiratory tract infections in children in southern China, particularly in children ≤5 years old. The prevalence peak of HMPV in this area appeared in spring, and the predominant subtype was B1. Meteorological factors, especially long sunshine duration, might decrease the HMPV prevalence. |
| first_indexed | 2024-03-09T10:52:59Z |
| format | Article |
| id | doaj.art-02fa7d9feba44d8aaf569b2ee3456317 |
| institution | Directory Open Access Journal |
| issn | 1201-9712 |
| language | English |
| last_indexed | 2024-03-09T10:52:59Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj.art-02fa7d9feba44d8aaf569b2ee34563172023-12-01T05:00:50ZengElsevierInternational Journal of Infectious Diseases1201-97122023-12-011374047Epidemiology, genetic characteristics, and association with meteorological factors of human metapneumovirus infection in children in southern China: A 10-year retrospective studyHengming Ye0Shuqing Zhang1Kexin Zhang2Yizhe Li3Delin Chen4Yongyao Tan5Linyue Liang6Minjie Liu7Jingyao Liang8Shu An9Jueheng Wu10Xun Zhu11Mengfeng Li12Zhenjian He13School of Public Health, Sun Yat-sen University, Guangzhou, China; Key Laboratory of Tropical Disease Control (Sun Yat-sen University), Ministry of Education, Guangzhou, China; Public Health Service Center of Bao'an District, Shenzhen, ChinaKey Laboratory of Tropical Disease Control (Sun Yat-sen University), Ministry of Education, Guangzhou, China; Department of Microbiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, ChinaSchool of Public Health, Sun Yat-sen University, Guangzhou, ChinaSchool of Public Health, Sun Yat-sen University, Guangzhou, ChinaDepartment of Microbiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, ChinaDepartment of Microbiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, ChinaDepartment of Microbiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, ChinaSchool of Public Health, Sun Yat-sen University, Guangzhou, ChinaSchool of Public Health, Sun Yat-sen University, Guangzhou, ChinaDepartment of Laboratory Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, ChinaKey Laboratory of Tropical Disease Control (Sun Yat-sen University), Ministry of Education, Guangzhou, China; Department of Microbiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, ChinaKey Laboratory of Tropical Disease Control (Sun Yat-sen University), Ministry of Education, Guangzhou, China; Department of Microbiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, ChinaKey Laboratory of Tropical Disease Control (Sun Yat-sen University), Ministry of Education, Guangzhou, China; Department of Microbiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China; Cancer Institute, Southern Medical University, Guangzhou, ChinaSchool of Public Health, Sun Yat-sen University, Guangzhou, China; Key Laboratory of Tropical Disease Control (Sun Yat-sen University), Ministry of Education, Guangzhou, China; Corresponding author.Objectives: This study aimed to determine the epidemiological and genetic features of human metapneumovirus (HMPV) infection in children in southern China, and the effect of meteorological factors on infection. Methods: 14,817 children (≤14 years) with acute respiratory tract infections from 2010 to 2019 were examined for HMPV and other respiratory viruses by real-time quantitative polymerase chain reaction. Full-length F gene of 54 positive samples were sequenced and subjected to phylogenetic analysis. The correlation between the HMPV-positive rate and meteorological factors was analyzed by linear regression analysis. Results: HMPV was detected in 524 (3.5%) children, who were mostly younger than 1 year. The seasonal peak of HMPV prevalence mainly occurred in spring. Respiratory syncytial virus was the most common virus coinfected with HMPV (5.3%). Phylogenetic analysis revealed that the sequenced HMPV strains belonged to four sublineages, including A2b (1.9%), A2c (31.5%), B1 (50.0%), and B2 (16.7%). After adjusting for all meteorological factors, sunshine duration was inversely correlated with the HMPV-positive rate. Conclusion: HMPV is an important respiratory pathogen that causes acute respiratory tract infections in children in southern China, particularly in children ≤5 years old. The prevalence peak of HMPV in this area appeared in spring, and the predominant subtype was B1. Meteorological factors, especially long sunshine duration, might decrease the HMPV prevalence.http://www.sciencedirect.com/science/article/pii/S1201971223007397Human metapneumovirusAcute respiratory infectionsEpidemiologyGenotypeMeteorological factors |
| spellingShingle | Hengming Ye Shuqing Zhang Kexin Zhang Yizhe Li Delin Chen Yongyao Tan Linyue Liang Minjie Liu Jingyao Liang Shu An Jueheng Wu Xun Zhu Mengfeng Li Zhenjian He Epidemiology, genetic characteristics, and association with meteorological factors of human metapneumovirus infection in children in southern China: A 10-year retrospective study International Journal of Infectious Diseases Human metapneumovirus Acute respiratory infections Epidemiology Genotype Meteorological factors |
| title | Epidemiology, genetic characteristics, and association with meteorological factors of human metapneumovirus infection in children in southern China: A 10-year retrospective study |
| title_full | Epidemiology, genetic characteristics, and association with meteorological factors of human metapneumovirus infection in children in southern China: A 10-year retrospective study |
| title_fullStr | Epidemiology, genetic characteristics, and association with meteorological factors of human metapneumovirus infection in children in southern China: A 10-year retrospective study |
| title_full_unstemmed | Epidemiology, genetic characteristics, and association with meteorological factors of human metapneumovirus infection in children in southern China: A 10-year retrospective study |
| title_short | Epidemiology, genetic characteristics, and association with meteorological factors of human metapneumovirus infection in children in southern China: A 10-year retrospective study |
| title_sort | epidemiology genetic characteristics and association with meteorological factors of human metapneumovirus infection in children in southern china a 10 year retrospective study |
| topic | Human metapneumovirus Acute respiratory infections Epidemiology Genotype Meteorological factors |
| url | http://www.sciencedirect.com/science/article/pii/S1201971223007397 |
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