Puumala Hantavirus Excretion Kinetics in Bank Voles (Myodes glareolus)
Puumala hantavirus is present in bank voles (Myodes glareolus) and is believed to be spread mainly by contaminated excretions. In this study, we subcutaneously inoculated 10 bank voles with Puumala virus and sampled excretions until day 133 postinfection. Levels of shed viral RNA peaked within 11–28...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Centers for Disease Control and Prevention
2008-08-01
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| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/14/8/08-0221_article |
| _version_ | 1819275019798183936 |
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| author | Jonas Hardestam Malin Karlsson Kerstin I. Falk Gert Olsson Jonas Klingström Åke Lundkvist |
| author_facet | Jonas Hardestam Malin Karlsson Kerstin I. Falk Gert Olsson Jonas Klingström Åke Lundkvist |
| author_sort | Jonas Hardestam |
| collection | DOAJ |
| description | Puumala hantavirus is present in bank voles (Myodes glareolus) and is believed to be spread mainly by contaminated excretions. In this study, we subcutaneously inoculated 10 bank voles with Puumala virus and sampled excretions until day 133 postinfection. Levels of shed viral RNA peaked within 11–28, 14–21, and 11–28 days postinfection for saliva, urine, and feces, respectively. The latest detection of viral RNA was 84, 44, and 44 days postinfection in saliva, urine, and feces, respectively. In contrast, blood of 5 of 6 animals contained viral RNA at day 133 postinfection, suggesting that bank voles secrete virus only during a limited time of the infection. Intranasal inoculations with bank vole saliva, urine, or feces were all infectious for virus-negative bank voles, indicating that these 3 transmission routes may occur in nature and that rodent saliva might play a role in transmission to humans. |
| first_indexed | 2024-12-23T23:17:40Z |
| format | Article |
| id | doaj.art-02faf3dd92794de7898cc1f023bcb459 |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-12-23T23:17:40Z |
| publishDate | 2008-08-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-02faf3dd92794de7898cc1f023bcb4592022-12-21T17:26:27ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592008-08-011481209121510.3201/eid1408.080221Puumala Hantavirus Excretion Kinetics in Bank Voles (Myodes glareolus)Jonas HardestamMalin KarlssonKerstin I. FalkGert OlssonJonas KlingströmÅke LundkvistPuumala hantavirus is present in bank voles (Myodes glareolus) and is believed to be spread mainly by contaminated excretions. In this study, we subcutaneously inoculated 10 bank voles with Puumala virus and sampled excretions until day 133 postinfection. Levels of shed viral RNA peaked within 11–28, 14–21, and 11–28 days postinfection for saliva, urine, and feces, respectively. The latest detection of viral RNA was 84, 44, and 44 days postinfection in saliva, urine, and feces, respectively. In contrast, blood of 5 of 6 animals contained viral RNA at day 133 postinfection, suggesting that bank voles secrete virus only during a limited time of the infection. Intranasal inoculations with bank vole saliva, urine, or feces were all infectious for virus-negative bank voles, indicating that these 3 transmission routes may occur in nature and that rodent saliva might play a role in transmission to humans.https://wwwnc.cdc.gov/eid/article/14/8/08-0221_articlePuumala hantavirusbank volezoonosissalivaurinefeces |
| spellingShingle | Jonas Hardestam Malin Karlsson Kerstin I. Falk Gert Olsson Jonas Klingström Åke Lundkvist Puumala Hantavirus Excretion Kinetics in Bank Voles (Myodes glareolus) Emerging Infectious Diseases Puumala hantavirus bank vole zoonosis saliva urine feces |
| title | Puumala Hantavirus Excretion Kinetics in Bank Voles (Myodes glareolus) |
| title_full | Puumala Hantavirus Excretion Kinetics in Bank Voles (Myodes glareolus) |
| title_fullStr | Puumala Hantavirus Excretion Kinetics in Bank Voles (Myodes glareolus) |
| title_full_unstemmed | Puumala Hantavirus Excretion Kinetics in Bank Voles (Myodes glareolus) |
| title_short | Puumala Hantavirus Excretion Kinetics in Bank Voles (Myodes glareolus) |
| title_sort | puumala hantavirus excretion kinetics in bank voles myodes glareolus |
| topic | Puumala hantavirus bank vole zoonosis saliva urine feces |
| url | https://wwwnc.cdc.gov/eid/article/14/8/08-0221_article |
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