Serological cross-reactivity between Merkel cell polyomavirus and two closely related chimpanzee polyomaviruses.
Phylogenetic analyses based on the major capsid protein sequence indicate that Merkel cell polyomavirus (MCPyV) and chimpanzee polyomaviruses (PtvPyV1, PtvPyV2), and similarly Trichodysplasia spinulosa-associated polyomavirus (TSPyV) and the orangutan polyomavirus (OraPyV1) are closely related. The...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4016208?pdf=render |
| _version_ | 1819104499391791104 |
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| author | Jérôme T J Nicol Etienne Liais Romain Potier Elisa Mazzoni Mauro Tognon Pierre Coursaget Antoine Touzé |
| author_facet | Jérôme T J Nicol Etienne Liais Romain Potier Elisa Mazzoni Mauro Tognon Pierre Coursaget Antoine Touzé |
| author_sort | Jérôme T J Nicol |
| collection | DOAJ |
| description | Phylogenetic analyses based on the major capsid protein sequence indicate that Merkel cell polyomavirus (MCPyV) and chimpanzee polyomaviruses (PtvPyV1, PtvPyV2), and similarly Trichodysplasia spinulosa-associated polyomavirus (TSPyV) and the orangutan polyomavirus (OraPyV1) are closely related. The existence of cross-reactivity between these polyomaviruses was therefore investigated. The findings indicated serological identity between the two chimpanzee polyomaviruses investigated and a high level of cross-reactivity with Merkel cell polyomavirus. In contrast, cross-reactivity was not observed between TSPyV and OraPyV1. Furthermore, specific antibodies to chimpanzee polyomaviruses were detected in chimpanzee sera by pre-incubation of sera with the different antigens, but not in human sera. |
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| format | Article |
| id | doaj.art-02fbbfd33d9b45a39be6821d24a3e1d3 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-22T02:07:19Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj.art-02fbbfd33d9b45a39be6821d24a3e1d32022-12-21T18:42:30ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0195e9703010.1371/journal.pone.0097030Serological cross-reactivity between Merkel cell polyomavirus and two closely related chimpanzee polyomaviruses.Jérôme T J NicolEtienne LiaisRomain PotierElisa MazzoniMauro TognonPierre CoursagetAntoine TouzéPhylogenetic analyses based on the major capsid protein sequence indicate that Merkel cell polyomavirus (MCPyV) and chimpanzee polyomaviruses (PtvPyV1, PtvPyV2), and similarly Trichodysplasia spinulosa-associated polyomavirus (TSPyV) and the orangutan polyomavirus (OraPyV1) are closely related. The existence of cross-reactivity between these polyomaviruses was therefore investigated. The findings indicated serological identity between the two chimpanzee polyomaviruses investigated and a high level of cross-reactivity with Merkel cell polyomavirus. In contrast, cross-reactivity was not observed between TSPyV and OraPyV1. Furthermore, specific antibodies to chimpanzee polyomaviruses were detected in chimpanzee sera by pre-incubation of sera with the different antigens, but not in human sera.http://europepmc.org/articles/PMC4016208?pdf=render |
| spellingShingle | Jérôme T J Nicol Etienne Liais Romain Potier Elisa Mazzoni Mauro Tognon Pierre Coursaget Antoine Touzé Serological cross-reactivity between Merkel cell polyomavirus and two closely related chimpanzee polyomaviruses. PLoS ONE |
| title | Serological cross-reactivity between Merkel cell polyomavirus and two closely related chimpanzee polyomaviruses. |
| title_full | Serological cross-reactivity between Merkel cell polyomavirus and two closely related chimpanzee polyomaviruses. |
| title_fullStr | Serological cross-reactivity between Merkel cell polyomavirus and two closely related chimpanzee polyomaviruses. |
| title_full_unstemmed | Serological cross-reactivity between Merkel cell polyomavirus and two closely related chimpanzee polyomaviruses. |
| title_short | Serological cross-reactivity between Merkel cell polyomavirus and two closely related chimpanzee polyomaviruses. |
| title_sort | serological cross reactivity between merkel cell polyomavirus and two closely related chimpanzee polyomaviruses |
| url | http://europepmc.org/articles/PMC4016208?pdf=render |
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