Toxoflavin analog D43 exerts antiproliferative effects on breast cancer by inducing ROS-mediated apoptosis and DNA damage

Toxoflavin analog D43 exerts antiproliferative effects on breast cancer by inducing ROS-mediated apoptosis and DNA damage

Abstract Triple-negative breast cancer (TNBC) is regarded as the deadliest subtype of breast cancer because of its high heterogeneity, aggressiveness, and limited treatment options. Toxoflavin has been reported to possess antitumor activity. In this study, a series of toxoflavin analogs were synthes...

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Bibliographic Details
Main Authors: Tingyue Wu, Wenjing Liu, Hui Chen, Lei Hou, Wenlong Ren, Longlong Zhang, Jinhui Hu, Haijun Chen, Ceshi Chen
Format: Article
Language:English
Published: Nature Portfolio 2024-02-01
Series:Scientific Reports
Subjects:
Toxoflavin
ROS
N-acetylcysteine (NAC)
DNA damage
Patient-derived breast cancer organoids (PDO)
Online Access:https://doi.org/10.1038/s41598-024-53843-1

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