Taurine and Ginsenoside Rf Induce BDNF Expression in SH-SY5Y Cells: A Potential Role of BDNF in Corticosterone-Triggered Cellular Damage
This study shows that taurine and ginsenoside Rf act synergistically to increase the expression of brain-derived neurotrophic factor (BDNF) in SH-SY5Y human neuroblastoma cells in a dose- and time-dependent manner. The increase of BDNF mRNA by taurine and ginsenoside Rf was markedly attenuated by in...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-06-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/25/12/2819 |
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| author | Won Jin Lee Gyeong Hee Lee Jinwoo Hur Hyuk Gyoon Lee Eunsu Kim Jun Pil Won Youngjae Cho Mi-Jung Choi Han Geuk Seo |
| author_facet | Won Jin Lee Gyeong Hee Lee Jinwoo Hur Hyuk Gyoon Lee Eunsu Kim Jun Pil Won Youngjae Cho Mi-Jung Choi Han Geuk Seo |
| author_sort | Won Jin Lee |
| collection | DOAJ |
| description | This study shows that taurine and ginsenoside Rf act synergistically to increase the expression of brain-derived neurotrophic factor (BDNF) in SH-SY5Y human neuroblastoma cells in a dose- and time-dependent manner. The increase of BDNF mRNA by taurine and ginsenoside Rf was markedly attenuated by inhibitors of extracellular signal-regulated kinase and p38 mitogen-activated protein kinase. In addition, taurine and ginsenoside Rf protected cells from corticosterone-induced BDNF suppression and reduced cell viability and lactate dehydrogenase release. The results from this study showed that combined treatment with both taurine and ginsenoside Rf enhanced BDNF expression and protected cells against corticosterone-induced damage. |
| first_indexed | 2024-03-10T19:02:49Z |
| format | Article |
| id | doaj.art-02fe131dba1e435ebe23d5348470ccb7 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T19:02:49Z |
| publishDate | 2020-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-02fe131dba1e435ebe23d5348470ccb72023-11-20T04:15:38ZengMDPI AGMolecules1420-30492020-06-012512281910.3390/molecules25122819Taurine and Ginsenoside Rf Induce BDNF Expression in SH-SY5Y Cells: A Potential Role of BDNF in Corticosterone-Triggered Cellular DamageWon Jin Lee0Gyeong Hee Lee1Jinwoo Hur2Hyuk Gyoon Lee3Eunsu Kim4Jun Pil Won5Youngjae Cho6Mi-Jung Choi7Han Geuk Seo8Department of Food Science and Biotechnology of Animal Resources, College of Sang-Huh Life Science, Konkuk University, 120 Neungdong-ro, Gwangjin-Gu, Seoul 05029, KoreaDepartment of Food Science and Biotechnology of Animal Resources, College of Sang-Huh Life Science, Konkuk University, 120 Neungdong-ro, Gwangjin-Gu, Seoul 05029, KoreaDepartment of Food Science and Biotechnology of Animal Resources, College of Sang-Huh Life Science, Konkuk University, 120 Neungdong-ro, Gwangjin-Gu, Seoul 05029, KoreaDepartment of Food Science and Biotechnology of Animal Resources, College of Sang-Huh Life Science, Konkuk University, 120 Neungdong-ro, Gwangjin-Gu, Seoul 05029, KoreaDepartment of Food Science and Biotechnology of Animal Resources, College of Sang-Huh Life Science, Konkuk University, 120 Neungdong-ro, Gwangjin-Gu, Seoul 05029, KoreaDepartment of Food Science and Biotechnology of Animal Resources, College of Sang-Huh Life Science, Konkuk University, 120 Neungdong-ro, Gwangjin-Gu, Seoul 05029, KoreaDepartment of Food Science and Biotechnology of Animal Resources, College of Sang-Huh Life Science, Konkuk University, 120 Neungdong-ro, Gwangjin-Gu, Seoul 05029, KoreaDepartment of Food Science and Biotechnology of Animal Resources, College of Sang-Huh Life Science, Konkuk University, 120 Neungdong-ro, Gwangjin-Gu, Seoul 05029, KoreaDepartment of Food Science and Biotechnology of Animal Resources, College of Sang-Huh Life Science, Konkuk University, 120 Neungdong-ro, Gwangjin-Gu, Seoul 05029, KoreaThis study shows that taurine and ginsenoside Rf act synergistically to increase the expression of brain-derived neurotrophic factor (BDNF) in SH-SY5Y human neuroblastoma cells in a dose- and time-dependent manner. The increase of BDNF mRNA by taurine and ginsenoside Rf was markedly attenuated by inhibitors of extracellular signal-regulated kinase and p38 mitogen-activated protein kinase. In addition, taurine and ginsenoside Rf protected cells from corticosterone-induced BDNF suppression and reduced cell viability and lactate dehydrogenase release. The results from this study showed that combined treatment with both taurine and ginsenoside Rf enhanced BDNF expression and protected cells against corticosterone-induced damage.https://www.mdpi.com/1420-3049/25/12/2819BDNFcorticosteroneginsenoside Rfneuronal damageSH-SY5Y cellstaurine |
| spellingShingle | Won Jin Lee Gyeong Hee Lee Jinwoo Hur Hyuk Gyoon Lee Eunsu Kim Jun Pil Won Youngjae Cho Mi-Jung Choi Han Geuk Seo Taurine and Ginsenoside Rf Induce BDNF Expression in SH-SY5Y Cells: A Potential Role of BDNF in Corticosterone-Triggered Cellular Damage Molecules BDNF corticosterone ginsenoside Rf neuronal damage SH-SY5Y cells taurine |
| title | Taurine and Ginsenoside Rf Induce BDNF Expression in SH-SY5Y Cells: A Potential Role of BDNF in Corticosterone-Triggered Cellular Damage |
| title_full | Taurine and Ginsenoside Rf Induce BDNF Expression in SH-SY5Y Cells: A Potential Role of BDNF in Corticosterone-Triggered Cellular Damage |
| title_fullStr | Taurine and Ginsenoside Rf Induce BDNF Expression in SH-SY5Y Cells: A Potential Role of BDNF in Corticosterone-Triggered Cellular Damage |
| title_full_unstemmed | Taurine and Ginsenoside Rf Induce BDNF Expression in SH-SY5Y Cells: A Potential Role of BDNF in Corticosterone-Triggered Cellular Damage |
| title_short | Taurine and Ginsenoside Rf Induce BDNF Expression in SH-SY5Y Cells: A Potential Role of BDNF in Corticosterone-Triggered Cellular Damage |
| title_sort | taurine and ginsenoside rf induce bdnf expression in sh sy5y cells a potential role of bdnf in corticosterone triggered cellular damage |
| topic | BDNF corticosterone ginsenoside Rf neuronal damage SH-SY5Y cells taurine |
| url | https://www.mdpi.com/1420-3049/25/12/2819 |
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