Acute exacerbation of COPD increases the risk of hip fractures: a nested case-control study from the Korea National Health Insurance Service
Background/Aims Hip fracture and acute exacerbation of chronic obstructive pulmonary disease (AE-COPD) could increase mortality in patients with COPD. There are no data on the relationship between AE-COPD and hip fracture, which may significantly affect the prognosis of patients with COPD. Therefore...
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| Format: | Article |
| Language: | English |
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The Korean Association of Internal Medicine
2022-05-01
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| Series: | The Korean Journal of Internal Medicine |
| Subjects: | |
| Online Access: | http://www.kjim.org/upload/pdf/kjim-2021-152.pdf |
| _version_ | 1818441005191397376 |
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| author | Kang-Mo Gu Sang-Won Yoon Sun-Young Jung Moon Seong Baek Won Young Kim Jae-Woo Jung Jae-Chol Choi Jong-Wook Shin Jae-Yeol Kim Byoung-Whui Choi In-Won Park |
| author_facet | Kang-Mo Gu Sang-Won Yoon Sun-Young Jung Moon Seong Baek Won Young Kim Jae-Woo Jung Jae-Chol Choi Jong-Wook Shin Jae-Yeol Kim Byoung-Whui Choi In-Won Park |
| author_sort | Kang-Mo Gu |
| collection | DOAJ |
| description | Background/Aims Hip fracture and acute exacerbation of chronic obstructive pulmonary disease (AE-COPD) could increase mortality in patients with COPD. There are no data on the relationship between AE-COPD and hip fracture, which may significantly affect the prognosis of patients with COPD. Therefore, we conducted this study to determine the effects of AE-COPD on hip fractures in patients with COPD. Methods This retrospective, nested, case-control study included 253,471 patients with COPD (≥ 40 years of age) identified from the Korea National Health Insurance Service-National Health Screening Cohort (NHIS-HEALS) from 2002 to 2015. Among 176,598 patients with COPD, 1,415 patients with hip fractures were identified. Each case was matched to one control for age (within 10 years), sex, and year of COPD diagnosis. We estimated the adjusted odds ratios (aORs) and 95% confidence intervals (CIs) for hip fractures associated with AE-COPD using conditional logistic regression analysis, adjusting for underlying diseases and smoking history. Results In patients with AE-COPD, the risk of hip fracture was 2.50 times higher, regardless of systemic corticosteroid use and underlying disease (aOR, 2.50; 95% CI, 1.67 to 3.75). The risk of hip fracture increased if there was one episode of AE in the year before hip fractures (aOR, 2.25; 95% CI, 1.66 to 3.05). Moreover, the risk of hip fracture also increased in patients with more than two episodes of AE the year before hip fractures (aOR, 2.57; 95% CI, 1.61 to 4.10). Conclusions AE-COPD increases the risk of hip fracture regardless of underlying diseases, including osteoporosis, and treatment with systemic corticosteroids. |
| first_indexed | 2024-12-14T18:21:22Z |
| format | Article |
| id | doaj.art-02ff02147dfd4a8c9c29db607acbef5b |
| institution | Directory Open Access Journal |
| issn | 1226-3303 2005-6648 |
| language | English |
| last_indexed | 2024-12-14T18:21:22Z |
| publishDate | 2022-05-01 |
| publisher | The Korean Association of Internal Medicine |
| record_format | Article |
| series | The Korean Journal of Internal Medicine |
| spelling | doaj.art-02ff02147dfd4a8c9c29db607acbef5b2022-12-21T22:52:03ZengThe Korean Association of Internal MedicineThe Korean Journal of Internal Medicine1226-33032005-66482022-05-0137363163810.3904/kjim.2021.152170645Acute exacerbation of COPD increases the risk of hip fractures: a nested case-control study from the Korea National Health Insurance ServiceKang-Mo Gu0Sang-Won Yoon1Sun-Young Jung2Moon Seong Baek3Won Young Kim4Jae-Woo Jung5Jae-Chol Choi6Jong-Wook Shin7Jae-Yeol Kim8Byoung-Whui Choi9In-Won Park10 Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea College of Pharmacy, Chung-Ang University, Seoul, Korea Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, KoreaBackground/Aims Hip fracture and acute exacerbation of chronic obstructive pulmonary disease (AE-COPD) could increase mortality in patients with COPD. There are no data on the relationship between AE-COPD and hip fracture, which may significantly affect the prognosis of patients with COPD. Therefore, we conducted this study to determine the effects of AE-COPD on hip fractures in patients with COPD. Methods This retrospective, nested, case-control study included 253,471 patients with COPD (≥ 40 years of age) identified from the Korea National Health Insurance Service-National Health Screening Cohort (NHIS-HEALS) from 2002 to 2015. Among 176,598 patients with COPD, 1,415 patients with hip fractures were identified. Each case was matched to one control for age (within 10 years), sex, and year of COPD diagnosis. We estimated the adjusted odds ratios (aORs) and 95% confidence intervals (CIs) for hip fractures associated with AE-COPD using conditional logistic regression analysis, adjusting for underlying diseases and smoking history. Results In patients with AE-COPD, the risk of hip fracture was 2.50 times higher, regardless of systemic corticosteroid use and underlying disease (aOR, 2.50; 95% CI, 1.67 to 3.75). The risk of hip fracture increased if there was one episode of AE in the year before hip fractures (aOR, 2.25; 95% CI, 1.66 to 3.05). Moreover, the risk of hip fracture also increased in patients with more than two episodes of AE the year before hip fractures (aOR, 2.57; 95% CI, 1.61 to 4.10). Conclusions AE-COPD increases the risk of hip fracture regardless of underlying diseases, including osteoporosis, and treatment with systemic corticosteroids.http://www.kjim.org/upload/pdf/kjim-2021-152.pdfacute exacerbationhip fracturespulmonary diseasechronic obstructive |
| spellingShingle | Kang-Mo Gu Sang-Won Yoon Sun-Young Jung Moon Seong Baek Won Young Kim Jae-Woo Jung Jae-Chol Choi Jong-Wook Shin Jae-Yeol Kim Byoung-Whui Choi In-Won Park Acute exacerbation of COPD increases the risk of hip fractures: a nested case-control study from the Korea National Health Insurance Service The Korean Journal of Internal Medicine acute exacerbation hip fractures pulmonary disease chronic obstructive |
| title | Acute exacerbation of COPD increases the risk of hip fractures: a nested case-control study from the Korea National Health Insurance Service |
| title_full | Acute exacerbation of COPD increases the risk of hip fractures: a nested case-control study from the Korea National Health Insurance Service |
| title_fullStr | Acute exacerbation of COPD increases the risk of hip fractures: a nested case-control study from the Korea National Health Insurance Service |
| title_full_unstemmed | Acute exacerbation of COPD increases the risk of hip fractures: a nested case-control study from the Korea National Health Insurance Service |
| title_short | Acute exacerbation of COPD increases the risk of hip fractures: a nested case-control study from the Korea National Health Insurance Service |
| title_sort | acute exacerbation of copd increases the risk of hip fractures a nested case control study from the korea national health insurance service |
| topic | acute exacerbation hip fractures pulmonary disease chronic obstructive |
| url | http://www.kjim.org/upload/pdf/kjim-2021-152.pdf |
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