Antibiofilm Activity of a Broad-Range Recombinant Endolysin LysECD7: In Vitro and In Vivo Study

Antibiofilm Activity of a Broad-Range Recombinant Endolysin LysECD7: In Vitro and In Vivo Study

Surfaces of implanted medical devices are highly susceptible to biofilm formation. Bacteria in biofilms are embedded in a self-produced extracellular matrix that inhibits the penetration of antibiotics and significantly contributes to the mechanical stability of the colonizing community which leads...

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Bibliographic Details
Main Authors: Mikhail V. Fursov, Radmila O. Abdrakhmanova, Nataliia P. Antonova, Daria V. Vasina, Anastasia D. Kolchanova, Olga A. Bashkina, Oleg V. Rubalsky, Marina A. Samotrueva, Vasiliy D. Potapov, Valentine V. Makarov, Sergey M. Yudin, Alexander L. Gintsburg, Artem P. Tkachuk, Vladimir A. Gushchin, Evgenii O. Rubalskii
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Viruses
Subjects:
endolysin
biofilm degradation
drug-resistant bacteria
implant-associated infection model
animal trial
Online Access:https://www.mdpi.com/1999-4915/12/5/545

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