Current Therapeutic Landscape and Safety Roadmap for Targeting the Aryl Hydrocarbon Receptor in Inflammatory Gastrointestinal Indications

Current Therapeutic Landscape and Safety Roadmap for Targeting the Aryl Hydrocarbon Receptor in Inflammatory Gastrointestinal Indications

Target modulation of the AhR for inflammatory gastrointestinal (GI) conditions holds great promise but also the potential for safety liabilities both within and beyond the GI tract. The ubiquitous expression of the AhR across mammalian tissues coupled with its role in diverse signaling pathways make...

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Bibliographic Details
Main Authors: Samantha C. Faber, Tejas S. Lahoti, Ewan R. Taylor, Lauren Lewis, Jessica M. Sapiro, Vicencia Toledo Sales, Yvonne P. Dragan, Brandon D. Jeffy
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Cells
Subjects:
aryl hydrocarbon receptor
CYP1A1
gastrointestinal toxicity
inflammation
PROTAC
oligonucleotides
Online Access:https://www.mdpi.com/2073-4409/11/10/1708

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