Type-2 CD8+ T-cell formation relies on interleukin-33 and is linked to asthma exacerbations

Type-2 CD8+ T-cell formation relies on interleukin-33 and is linked to asthma exacerbations

Abstract CD4+ T helper 2 (Th2) cells and group 2 innate lymphoid cells are considered the main producers of type-2 cytokines that fuel chronic airway inflammation in allergic asthma. However, CD8+ cytotoxic T (Tc) cells - critical for anti-viral defense - can also produce type-2 cytokines (referred...

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Bibliographic Details
Main Authors: Esmee K. van der Ploeg, Lisette Krabbendam, Heleen Vroman, Menno van Nimwegen, Marjolein J. W. de Bruijn, Geertje M. de Boer, Ingrid M. Bergen, Mirjam Kool, Gerdien A. Tramper-Standers, Gert-Jan Braunstahl, Danny Huylebroeck, Rudi W. Hendriks, Ralph Stadhouders
Format: Article
Language:English
Published: Nature Portfolio 2023-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-40820-x

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