TRPM8 mechanism of autonomic nerve response to cold in respiratory airway
<p>Abstract</p> <p>Breathing cold air without proper temperature exchange can induce strong respiratory autonomic responses including cough, airway constriction and mucosal secretion, and can exacerbate existing asthma conditions and even directly trigger an asthma attack. Vagal af...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2008-06-01
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| Series: | Molecular Pain |
| Online Access: | http://www.molecularpain.com/content/4/1/22 |
| _version_ | 1818173076976697344 |
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| author | Wang Cong-Yi Tominaga Makoto Johnson Richard D Chen Meng Ling Jennifer X Xing Hong Gu Jianguo |
| author_facet | Wang Cong-Yi Tominaga Makoto Johnson Richard D Chen Meng Ling Jennifer X Xing Hong Gu Jianguo |
| author_sort | Wang Cong-Yi |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Breathing cold air without proper temperature exchange can induce strong respiratory autonomic responses including cough, airway constriction and mucosal secretion, and can exacerbate existing asthma conditions and even directly trigger an asthma attack. Vagal afferent fiber is thought to be involved in the cold-induced respiratory responses through autonomic nerve reflex. However, molecular mechanisms by which vagal afferent fibers are excited by cold remain unknown. Using retrograde labeling, immunostaining, calcium imaging, and electrophysiological recordings, here we show that a subpopulation of airway vagal afferent nerves express TRPM8 receptors and that activation of TRPM8 receptors by cold excites these airway autonomic nerves. Thus activation of TRPM8 receptors may provoke autonomic nerve reflex to increase airway resistance. This putative autonomic response may be associated with cold-induced exacerbation of asthma and other pulmonary disorders, making TRPM8 receptors a possible target for prevention of cold-associated respiratory disorders.</p> |
| first_indexed | 2024-12-11T19:22:46Z |
| format | Article |
| id | doaj.art-0306d03e729940a8b03dfc5405928e94 |
| institution | Directory Open Access Journal |
| issn | 1744-8069 |
| language | English |
| last_indexed | 2024-12-11T19:22:46Z |
| publishDate | 2008-06-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Molecular Pain |
| spelling | doaj.art-0306d03e729940a8b03dfc5405928e942022-12-22T00:53:29ZengSAGE PublishingMolecular Pain1744-80692008-06-01412210.1186/1744-8069-4-22TRPM8 mechanism of autonomic nerve response to cold in respiratory airwayWang Cong-YiTominaga MakotoJohnson Richard DChen MengLing Jennifer XXing HongGu Jianguo<p>Abstract</p> <p>Breathing cold air without proper temperature exchange can induce strong respiratory autonomic responses including cough, airway constriction and mucosal secretion, and can exacerbate existing asthma conditions and even directly trigger an asthma attack. Vagal afferent fiber is thought to be involved in the cold-induced respiratory responses through autonomic nerve reflex. However, molecular mechanisms by which vagal afferent fibers are excited by cold remain unknown. Using retrograde labeling, immunostaining, calcium imaging, and electrophysiological recordings, here we show that a subpopulation of airway vagal afferent nerves express TRPM8 receptors and that activation of TRPM8 receptors by cold excites these airway autonomic nerves. Thus activation of TRPM8 receptors may provoke autonomic nerve reflex to increase airway resistance. This putative autonomic response may be associated with cold-induced exacerbation of asthma and other pulmonary disorders, making TRPM8 receptors a possible target for prevention of cold-associated respiratory disorders.</p>http://www.molecularpain.com/content/4/1/22 |
| spellingShingle | Wang Cong-Yi Tominaga Makoto Johnson Richard D Chen Meng Ling Jennifer X Xing Hong Gu Jianguo TRPM8 mechanism of autonomic nerve response to cold in respiratory airway Molecular Pain |
| title | TRPM8 mechanism of autonomic nerve response to cold in respiratory airway |
| title_full | TRPM8 mechanism of autonomic nerve response to cold in respiratory airway |
| title_fullStr | TRPM8 mechanism of autonomic nerve response to cold in respiratory airway |
| title_full_unstemmed | TRPM8 mechanism of autonomic nerve response to cold in respiratory airway |
| title_short | TRPM8 mechanism of autonomic nerve response to cold in respiratory airway |
| title_sort | trpm8 mechanism of autonomic nerve response to cold in respiratory airway |
| url | http://www.molecularpain.com/content/4/1/22 |
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