Ferrets as Models for Influenza Virus Transmission Studies and Pandemic Risk Assessments
The ferret transmission model is extensively used to assess the pandemic potential of emerging influenza viruses, yet experimental conditions and reported results vary among laboratories. Such variation can be a critical consideration when contextualizing results from independent risk-assessment stu...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Centers for Disease Control and Prevention
2018-06-01
|
| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/24/6/17-2114_article |
| _version_ | 1819160346003243008 |
|---|---|
| author | Jessica A. Belser Wendy Barclay Ian Barr Ron A.M. Fouchier Ryota Matsuyama Hiroshi Nishiura Malik Peiris Charles J. Russell Kanta Subbarao Huachen Zhu Hui-Ling Yen |
| author_facet | Jessica A. Belser Wendy Barclay Ian Barr Ron A.M. Fouchier Ryota Matsuyama Hiroshi Nishiura Malik Peiris Charles J. Russell Kanta Subbarao Huachen Zhu Hui-Ling Yen |
| author_sort | Jessica A. Belser |
| collection | DOAJ |
| description | The ferret transmission model is extensively used to assess the pandemic potential of emerging influenza viruses, yet experimental conditions and reported results vary among laboratories. Such variation can be a critical consideration when contextualizing results from independent risk-assessment studies of novel and emerging influenza viruses. To streamline interpretation of data generated in different laboratories, we provide a consensus on experimental parameters that define risk-assessment experiments of influenza virus transmissibility, including disclosure of variables known or suspected to contribute to experimental variability in this model, and advocate adoption of more standardized practices. We also discuss current limitations of the ferret transmission model and highlight continued refinements and advances to this model ongoing in laboratories. Understanding, disclosing, and standardizing the critical parameters of ferret transmission studies will improve the comparability and reproducibility of pandemic influenza risk assessment and increase the statistical power and, perhaps, accuracy of this model. |
| first_indexed | 2024-12-22T16:54:59Z |
| format | Article |
| id | doaj.art-03075dd1712042da96af07a6b1a75f9e |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-12-22T16:54:59Z |
| publishDate | 2018-06-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-03075dd1712042da96af07a6b1a75f9e2022-12-21T18:19:28ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592018-06-0124696597110.3201/eid2406.172114Ferrets as Models for Influenza Virus Transmission Studies and Pandemic Risk AssessmentsJessica A. BelserWendy BarclayIan BarrRon A.M. FouchierRyota MatsuyamaHiroshi NishiuraMalik PeirisCharles J. RussellKanta SubbaraoHuachen ZhuHui-Ling YenThe ferret transmission model is extensively used to assess the pandemic potential of emerging influenza viruses, yet experimental conditions and reported results vary among laboratories. Such variation can be a critical consideration when contextualizing results from independent risk-assessment studies of novel and emerging influenza viruses. To streamline interpretation of data generated in different laboratories, we provide a consensus on experimental parameters that define risk-assessment experiments of influenza virus transmissibility, including disclosure of variables known or suspected to contribute to experimental variability in this model, and advocate adoption of more standardized practices. We also discuss current limitations of the ferret transmission model and highlight continued refinements and advances to this model ongoing in laboratories. Understanding, disclosing, and standardizing the critical parameters of ferret transmission studies will improve the comparability and reproducibility of pandemic influenza risk assessment and increase the statistical power and, perhaps, accuracy of this model.https://wwwnc.cdc.gov/eid/article/24/6/17-2114_articleferretsinfluenza virusespandemicsrisk assessmenttransmissioninfluenza |
| spellingShingle | Jessica A. Belser Wendy Barclay Ian Barr Ron A.M. Fouchier Ryota Matsuyama Hiroshi Nishiura Malik Peiris Charles J. Russell Kanta Subbarao Huachen Zhu Hui-Ling Yen Ferrets as Models for Influenza Virus Transmission Studies and Pandemic Risk Assessments Emerging Infectious Diseases ferrets influenza viruses pandemics risk assessment transmission influenza |
| title | Ferrets as Models for Influenza Virus Transmission Studies and Pandemic Risk Assessments |
| title_full | Ferrets as Models for Influenza Virus Transmission Studies and Pandemic Risk Assessments |
| title_fullStr | Ferrets as Models for Influenza Virus Transmission Studies and Pandemic Risk Assessments |
| title_full_unstemmed | Ferrets as Models for Influenza Virus Transmission Studies and Pandemic Risk Assessments |
| title_short | Ferrets as Models for Influenza Virus Transmission Studies and Pandemic Risk Assessments |
| title_sort | ferrets as models for influenza virus transmission studies and pandemic risk assessments |
| topic | ferrets influenza viruses pandemics risk assessment transmission influenza |
| url | https://wwwnc.cdc.gov/eid/article/24/6/17-2114_article |
| work_keys_str_mv | AT jessicaabelser ferretsasmodelsforinfluenzavirustransmissionstudiesandpandemicriskassessments AT wendybarclay ferretsasmodelsforinfluenzavirustransmissionstudiesandpandemicriskassessments AT ianbarr ferretsasmodelsforinfluenzavirustransmissionstudiesandpandemicriskassessments AT ronamfouchier ferretsasmodelsforinfluenzavirustransmissionstudiesandpandemicriskassessments AT ryotamatsuyama ferretsasmodelsforinfluenzavirustransmissionstudiesandpandemicriskassessments AT hiroshinishiura ferretsasmodelsforinfluenzavirustransmissionstudiesandpandemicriskassessments AT malikpeiris ferretsasmodelsforinfluenzavirustransmissionstudiesandpandemicriskassessments AT charlesjrussell ferretsasmodelsforinfluenzavirustransmissionstudiesandpandemicriskassessments AT kantasubbarao ferretsasmodelsforinfluenzavirustransmissionstudiesandpandemicriskassessments AT huachenzhu ferretsasmodelsforinfluenzavirustransmissionstudiesandpandemicriskassessments AT huilingyen ferretsasmodelsforinfluenzavirustransmissionstudiesandpandemicriskassessments |