Tabernaemontana divaricata leaves extract exacerbate burying behavior in mice
Objective: Tabernaemontana divaricata (TD) from Apocynaceae family offers the traditional folklore medicinal benefits such as an anti-epileptic, anti-mania, brain tonic, and anti-oxidant. The aim of the present study was to evaluate the effect of ethanolic extract of TD leaves on burying behavior in...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2015-06-01
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| Series: | Avicenna Journal of Phytomedicine |
| Subjects: | |
| Online Access: | http://ajp.mums.ac.ir/pdf_4329_2692b85aa1f8d9d307e07e25f5e2b110.html |
| _version_ | 1811201165920043008 |
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| author | Raj Chanchal A. Balasubramaniam Raj Navin Sayyed Nadeem |
| author_facet | Raj Chanchal A. Balasubramaniam Raj Navin Sayyed Nadeem |
| author_sort | Raj Chanchal |
| collection | DOAJ |
| description | Objective: Tabernaemontana divaricata (TD) from Apocynaceae family offers the traditional folklore medicinal benefits such as an anti-epileptic, anti-mania, brain tonic, and anti-oxidant. The aim of the present study was to evaluate the effect of ethanolic extract of TD leaves on burying behavior in mice. Materials and Methods:Mice were treated with oral administration (p.o.) of ethanolic extract of TD (100, 200, and 300 mg/kg). Fluoxetine (FLX, a selective serotonin reuptake inhibitor) was used as a reference drug. Obsessive-compulsive behavior was evaluated using marble-burying apparatus. Results:TD at doses of 100, 200, and 300 mg/kg dose-dependently inhibited the obsessive and compulsive behavior. The similar results were obtained from 5, 10, and 20 mg/kg of FLX. TD and FLX did not affect motor activity. Conclusion: The results indicated that TD and FLX produced similar inhibitory effects on marble-burying behavior. |
| first_indexed | 2024-04-12T02:17:23Z |
| format | Article |
| id | doaj.art-0308328aa6d540799fe7e34d80b03b03 |
| institution | Directory Open Access Journal |
| issn | 2228-7930 2228-7949 |
| language | English |
| last_indexed | 2024-04-12T02:17:23Z |
| publishDate | 2015-06-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Avicenna Journal of Phytomedicine |
| spelling | doaj.art-0308328aa6d540799fe7e34d80b03b032022-12-22T03:52:13ZengMashhad University of Medical SciencesAvicenna Journal of Phytomedicine2228-79302228-79492015-06-01542822874329Tabernaemontana divaricata leaves extract exacerbate burying behavior in miceRaj Chanchal0A. Balasubramaniam1Raj Navin2Sayyed Nadeem3Technocrats Institute of Technology Pharmacy, Anand Nagar, Bhopal- 462 021 (M.P.), IndiaTechnocrats Institute of Technology Pharmacy, Anand Nagar, Bhopal- 462 021 (M.P.), IndiaTechnocrats Institute of Technology Pharmacy, Anand Nagar, Bhopal- 462 021 (M.P.), IndiaTechnocrats Institute of Technology Pharmacy, Anand Nagar, Bhopal- 462 021 (M.P.), IndiaObjective: Tabernaemontana divaricata (TD) from Apocynaceae family offers the traditional folklore medicinal benefits such as an anti-epileptic, anti-mania, brain tonic, and anti-oxidant. The aim of the present study was to evaluate the effect of ethanolic extract of TD leaves on burying behavior in mice. Materials and Methods:Mice were treated with oral administration (p.o.) of ethanolic extract of TD (100, 200, and 300 mg/kg). Fluoxetine (FLX, a selective serotonin reuptake inhibitor) was used as a reference drug. Obsessive-compulsive behavior was evaluated using marble-burying apparatus. Results:TD at doses of 100, 200, and 300 mg/kg dose-dependently inhibited the obsessive and compulsive behavior. The similar results were obtained from 5, 10, and 20 mg/kg of FLX. TD and FLX did not affect motor activity. Conclusion: The results indicated that TD and FLX produced similar inhibitory effects on marble-burying behavior.http://ajp.mums.ac.ir/pdf_4329_2692b85aa1f8d9d307e07e25f5e2b110.htmlTabernaemontana divaricateFluoxetineBurying behavior |
| spellingShingle | Raj Chanchal A. Balasubramaniam Raj Navin Sayyed Nadeem Tabernaemontana divaricata leaves extract exacerbate burying behavior in mice Avicenna Journal of Phytomedicine Tabernaemontana divaricate Fluoxetine Burying behavior |
| title | Tabernaemontana divaricata leaves extract exacerbate burying behavior in mice |
| title_full | Tabernaemontana divaricata leaves extract exacerbate burying behavior in mice |
| title_fullStr | Tabernaemontana divaricata leaves extract exacerbate burying behavior in mice |
| title_full_unstemmed | Tabernaemontana divaricata leaves extract exacerbate burying behavior in mice |
| title_short | Tabernaemontana divaricata leaves extract exacerbate burying behavior in mice |
| title_sort | tabernaemontana divaricata leaves extract exacerbate burying behavior in mice |
| topic | Tabernaemontana divaricate Fluoxetine Burying behavior |
| url | http://ajp.mums.ac.ir/pdf_4329_2692b85aa1f8d9d307e07e25f5e2b110.html |
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