Extracellular vesicle associated long non-coding RNAs functionally enhance cell viability
Cells communicate with one another to create microenvironments and share resources. One avenue by which cells communicate is through the action of exosomes. Exosomes are extracellular vesicles that are released by one cell and taken up by neighbouring cells. But how exosomes instigate communication...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
KeAi Communications Co., Ltd.
2016-10-01
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| Series: | Non-coding RNA Research |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2468054016300014 |
| _version_ | 1797204368157573120 |
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| author | Chris Hewson David Capraro Jon Burdach Noel Whitaker Kevin V. Morris |
| author_facet | Chris Hewson David Capraro Jon Burdach Noel Whitaker Kevin V. Morris |
| author_sort | Chris Hewson |
| collection | DOAJ |
| description | Cells communicate with one another to create microenvironments and share resources. One avenue by which cells communicate is through the action of exosomes. Exosomes are extracellular vesicles that are released by one cell and taken up by neighbouring cells. But how exosomes instigate communication between cells has remained largely unknown. We present evidence here that particular long non-coding RNA molecules are preferentially packaged into exosomes. We also find that a specific class of these exosome associated non-coding RNAs functionally modulate cell viability by direct interactions with l-lactate dehydrogenase B (LDHB), high-mobility group protein 17 (HMG-17), and CSF2RB, proteins involved in metabolism, nucleosomal architecture and cell signalling respectively. Knowledge of this endogenous cell to cell pathway, those proteins interacting with exosome associated non-coding transcripts and their interacting domains, could lead to a better understanding of not only cell to cell interactions but also the development of exosome targeted approaches in patient specific cell-based therapies. Keywords: Non-coding RNA, Extracellular RNA, Exosomes, Retroelement, Pseudogene |
| first_indexed | 2024-04-24T08:34:07Z |
| format | Article |
| id | doaj.art-0309be66f49e45a2990c905c99f1dca7 |
| institution | Directory Open Access Journal |
| issn | 2468-0540 |
| language | English |
| last_indexed | 2024-04-24T08:34:07Z |
| publishDate | 2016-10-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Non-coding RNA Research |
| spelling | doaj.art-0309be66f49e45a2990c905c99f1dca72024-04-16T17:37:42ZengKeAi Communications Co., Ltd.Non-coding RNA Research2468-05402016-10-0111311Extracellular vesicle associated long non-coding RNAs functionally enhance cell viabilityChris Hewson0David Capraro1Jon Burdach2Noel Whitaker3Kevin V. Morris4The University of New South Wales, Biotechnology and Biomedical Sciences, Sydney, NSW 2052, AustraliaThe University of New South Wales, Biotechnology and Biomedical Sciences, Sydney, NSW 2052, AustraliaThe University of New South Wales, Biotechnology and Biomedical Sciences, Sydney, NSW 2052, AustraliaThe University of New South Wales, Biotechnology and Biomedical Sciences, Sydney, NSW 2052, AustraliaThe University of New South Wales, Biotechnology and Biomedical Sciences, Sydney, NSW 2052, Australia; Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, United States; City of Hope â Beckman Research Institute, Center for Gene Therapy, Duarte, CA 91010, United States; Corresponding author. City of Hope â Beckman Research Institute, Center for Gene Therapy, Duarte, CA 91010, United States.Cells communicate with one another to create microenvironments and share resources. One avenue by which cells communicate is through the action of exosomes. Exosomes are extracellular vesicles that are released by one cell and taken up by neighbouring cells. But how exosomes instigate communication between cells has remained largely unknown. We present evidence here that particular long non-coding RNA molecules are preferentially packaged into exosomes. We also find that a specific class of these exosome associated non-coding RNAs functionally modulate cell viability by direct interactions with l-lactate dehydrogenase B (LDHB), high-mobility group protein 17 (HMG-17), and CSF2RB, proteins involved in metabolism, nucleosomal architecture and cell signalling respectively. Knowledge of this endogenous cell to cell pathway, those proteins interacting with exosome associated non-coding transcripts and their interacting domains, could lead to a better understanding of not only cell to cell interactions but also the development of exosome targeted approaches in patient specific cell-based therapies. Keywords: Non-coding RNA, Extracellular RNA, Exosomes, Retroelement, Pseudogenehttp://www.sciencedirect.com/science/article/pii/S2468054016300014 |
| spellingShingle | Chris Hewson David Capraro Jon Burdach Noel Whitaker Kevin V. Morris Extracellular vesicle associated long non-coding RNAs functionally enhance cell viability Non-coding RNA Research |
| title | Extracellular vesicle associated long non-coding RNAs functionally enhance cell viability |
| title_full | Extracellular vesicle associated long non-coding RNAs functionally enhance cell viability |
| title_fullStr | Extracellular vesicle associated long non-coding RNAs functionally enhance cell viability |
| title_full_unstemmed | Extracellular vesicle associated long non-coding RNAs functionally enhance cell viability |
| title_short | Extracellular vesicle associated long non-coding RNAs functionally enhance cell viability |
| title_sort | extracellular vesicle associated long non coding rnas functionally enhance cell viability |
| url | http://www.sciencedirect.com/science/article/pii/S2468054016300014 |
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