Autoimmune encephalopathy associated with thyroid autoantibodies as the cause of reversible cognitive impairment
We herewith describe a patient with acute confusion, expressive aphasia and generalized seizures. A through workup excluded most causes of encephalopathy. He was, however, found to have TSH = 18.6 MIU/ml, T3reverse = 0.44nmol/L, T4 = 0.8ng/dl and Anti-Thyroid-Peroxidase AB titer >1000 IU/...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Greater Baltimore Medical Center
2012-04-01
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| Series: | Journal of Community Hospital Internal Medicine Perspectives |
| Subjects: | |
| Online Access: | http://www.jchimp.net/index.php/jchimp/article/view/11453/pdf_1 |
| _version_ | 1797965525716828160 |
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| author | Robert Dobbin Chow Nechama Bernhardt Natallia Maroz |
| author_facet | Robert Dobbin Chow Nechama Bernhardt Natallia Maroz |
| author_sort | Robert Dobbin Chow |
| collection | DOAJ |
| description | We herewith describe a patient with acute confusion, expressive aphasia and generalized seizures. A through workup excluded most causes of encephalopathy. He was, however, found to have TSH = 18.6 MIU/ml, T3reverse = 0.44nmol/L, T4 = 0.8ng/dl and Anti-Thyroid-Peroxidase AB titer >1000 IU/ml. Based on the above findings the patient was diagnosed with Hashimoto's encephalopathy and his mental status showed dramatic improvement (MMS 30/30) with high dose prednisone. Hashimoto's encephalopathy is rare disorder of presumed autoimmune origin characterized by cognitive decline, seizures, neuro-psychiatric symptoms, high titers of Anti-Thyroid-Peroxidase AB, and a positive response to steroids. |
| first_indexed | 2024-04-11T02:00:16Z |
| format | Article |
| id | doaj.art-030dd2f7e7cb498e82a476fb981b43e7 |
| institution | Directory Open Access Journal |
| issn | 2000-9666 |
| language | English |
| last_indexed | 2024-04-11T02:00:16Z |
| publishDate | 2012-04-01 |
| publisher | Greater Baltimore Medical Center |
| record_format | Article |
| series | Journal of Community Hospital Internal Medicine Perspectives |
| spelling | doaj.art-030dd2f7e7cb498e82a476fb981b43e72023-01-03T04:08:27ZengGreater Baltimore Medical CenterJournal of Community Hospital Internal Medicine Perspectives2000-96662012-04-01211610.3402/jchimp.v2i1.11453Autoimmune encephalopathy associated with thyroid autoantibodies as the cause of reversible cognitive impairmentRobert Dobbin ChowNechama BernhardtNatallia MarozWe herewith describe a patient with acute confusion, expressive aphasia and generalized seizures. A through workup excluded most causes of encephalopathy. He was, however, found to have TSH = 18.6 MIU/ml, T3reverse = 0.44nmol/L, T4 = 0.8ng/dl and Anti-Thyroid-Peroxidase AB titer >1000 IU/ml. Based on the above findings the patient was diagnosed with Hashimoto's encephalopathy and his mental status showed dramatic improvement (MMS 30/30) with high dose prednisone. Hashimoto's encephalopathy is rare disorder of presumed autoimmune origin characterized by cognitive decline, seizures, neuro-psychiatric symptoms, high titers of Anti-Thyroid-Peroxidase AB, and a positive response to steroids.http://www.jchimp.net/index.php/jchimp/article/view/11453/pdf_1hashimotoreversible cognitive impairmentautoimmune encephalopathythyroid-peroxidase antibody |
| spellingShingle | Robert Dobbin Chow Nechama Bernhardt Natallia Maroz Autoimmune encephalopathy associated with thyroid autoantibodies as the cause of reversible cognitive impairment Journal of Community Hospital Internal Medicine Perspectives hashimoto reversible cognitive impairment autoimmune encephalopathy thyroid-peroxidase antibody |
| title | Autoimmune encephalopathy associated with thyroid autoantibodies as the cause of reversible cognitive impairment |
| title_full | Autoimmune encephalopathy associated with thyroid autoantibodies as the cause of reversible cognitive impairment |
| title_fullStr | Autoimmune encephalopathy associated with thyroid autoantibodies as the cause of reversible cognitive impairment |
| title_full_unstemmed | Autoimmune encephalopathy associated with thyroid autoantibodies as the cause of reversible cognitive impairment |
| title_short | Autoimmune encephalopathy associated with thyroid autoantibodies as the cause of reversible cognitive impairment |
| title_sort | autoimmune encephalopathy associated with thyroid autoantibodies as the cause of reversible cognitive impairment |
| topic | hashimoto reversible cognitive impairment autoimmune encephalopathy thyroid-peroxidase antibody |
| url | http://www.jchimp.net/index.php/jchimp/article/view/11453/pdf_1 |
| work_keys_str_mv | AT robertdobbinchow autoimmuneencephalopathyassociatedwiththyroidautoantibodiesasthecauseofreversiblecognitiveimpairment AT nechamabernhardt autoimmuneencephalopathyassociatedwiththyroidautoantibodiesasthecauseofreversiblecognitiveimpairment AT natalliamaroz autoimmuneencephalopathyassociatedwiththyroidautoantibodiesasthecauseofreversiblecognitiveimpairment |