GCY-20 signaling controls suppression of Caenorhabditis elegans egg laying by moderate cold
Summary: Organisms sensing environmental cues and internal states and integrating the sensory information to control fecundity are essential for survival and proliferation. The present study finds that a moderate cold temperature of 11°C reduces egg laying in Caenorhabditis elegans. ASEL and AWC neu...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-02-01
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| Series: | Cell Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124724000366 |
| _version_ | 1797291743069077504 |
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| author | Rong Li Yu Xu Xin Wen Yuan-Hua Chen Ping-Zhou Wang Jia-Lu Zhao Piao-Ping Wu Jing-Jing Wu Hui Liu Jia-Hao Huang Si-Jia Li Zheng-Xing Wu |
| author_facet | Rong Li Yu Xu Xin Wen Yuan-Hua Chen Ping-Zhou Wang Jia-Lu Zhao Piao-Ping Wu Jing-Jing Wu Hui Liu Jia-Hao Huang Si-Jia Li Zheng-Xing Wu |
| author_sort | Rong Li |
| collection | DOAJ |
| description | Summary: Organisms sensing environmental cues and internal states and integrating the sensory information to control fecundity are essential for survival and proliferation. The present study finds that a moderate cold temperature of 11°C reduces egg laying in Caenorhabditis elegans. ASEL and AWC neurons sense the cold via GCY-20 signaling and act antagonistically on egg laying through the ASEL and AWC/AIA/HSN circuits. Upon cold stimulation, ASEL and AWC release glutamate to activate and inhibit AIA interneurons by acting on highly and lowly sensitive ionotropic GLR-2 and GLC-3 receptors, respectively. AIA inhibits HSN motor neuron activity via acetylcholinergic ACR-14 receptor signaling and suppresses egg laying. Thus, ASEL and AWC initiate and reduce the cold suppression of egg laying. ASEL’s action on AIA and egg laying dominates AWC’s action. The biased opposite actions of these neurons on egg laying provide animals with a precise adaptation of reproductive behavior to environmental temperatures. |
| first_indexed | 2024-03-07T19:42:08Z |
| format | Article |
| id | doaj.art-030e837c4b374e62ae14dc2b4b052e25 |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-03-07T19:42:08Z |
| publishDate | 2024-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-030e837c4b374e62ae14dc2b4b052e252024-02-29T05:18:43ZengElsevierCell Reports2211-12472024-02-01432113708GCY-20 signaling controls suppression of Caenorhabditis elegans egg laying by moderate coldRong Li0Yu Xu1Xin Wen2Yuan-Hua Chen3Ping-Zhou Wang4Jia-Lu Zhao5Piao-Ping Wu6Jing-Jing Wu7Hui Liu8Jia-Hao Huang9Si-Jia Li10Zheng-Xing Wu11Key Laboratory of Molecular Biophysics of Ministry of Education, Institute of Biophysics and Biochemistry, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, ChinaKey Laboratory of Molecular Biophysics of Ministry of Education, Institute of Biophysics and Biochemistry, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, ChinaCollege of Life Science, Henan Agricultural University, Zhengzhou, Henan, ChinaKey Laboratory of Molecular Biophysics of Ministry of Education, Institute of Biophysics and Biochemistry, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, ChinaKey Laboratory of Molecular Biophysics of Ministry of Education, Institute of Biophysics and Biochemistry, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, ChinaKey Laboratory of Molecular Biophysics of Ministry of Education, Institute of Biophysics and Biochemistry, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, ChinaKey Laboratory of Molecular Biophysics of Ministry of Education, Institute of Biophysics and Biochemistry, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, ChinaKey Laboratory of Molecular Biophysics of Ministry of Education, Institute of Biophysics and Biochemistry, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, ChinaKey Laboratory of Molecular Biophysics of Ministry of Education, Institute of Biophysics and Biochemistry, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, ChinaKey Laboratory of Molecular Biophysics of Ministry of Education, Institute of Biophysics and Biochemistry, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, ChinaKey Laboratory of Molecular Biophysics of Ministry of Education, Institute of Biophysics and Biochemistry, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, ChinaKey Laboratory of Molecular Biophysics of Ministry of Education, Institute of Biophysics and Biochemistry, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China; Corresponding authorSummary: Organisms sensing environmental cues and internal states and integrating the sensory information to control fecundity are essential for survival and proliferation. The present study finds that a moderate cold temperature of 11°C reduces egg laying in Caenorhabditis elegans. ASEL and AWC neurons sense the cold via GCY-20 signaling and act antagonistically on egg laying through the ASEL and AWC/AIA/HSN circuits. Upon cold stimulation, ASEL and AWC release glutamate to activate and inhibit AIA interneurons by acting on highly and lowly sensitive ionotropic GLR-2 and GLC-3 receptors, respectively. AIA inhibits HSN motor neuron activity via acetylcholinergic ACR-14 receptor signaling and suppresses egg laying. Thus, ASEL and AWC initiate and reduce the cold suppression of egg laying. ASEL’s action on AIA and egg laying dominates AWC’s action. The biased opposite actions of these neurons on egg laying provide animals with a precise adaptation of reproductive behavior to environmental temperatures.http://www.sciencedirect.com/science/article/pii/S2211124724000366CP: Neuroscience |
| spellingShingle | Rong Li Yu Xu Xin Wen Yuan-Hua Chen Ping-Zhou Wang Jia-Lu Zhao Piao-Ping Wu Jing-Jing Wu Hui Liu Jia-Hao Huang Si-Jia Li Zheng-Xing Wu GCY-20 signaling controls suppression of Caenorhabditis elegans egg laying by moderate cold Cell Reports CP: Neuroscience |
| title | GCY-20 signaling controls suppression of Caenorhabditis elegans egg laying by moderate cold |
| title_full | GCY-20 signaling controls suppression of Caenorhabditis elegans egg laying by moderate cold |
| title_fullStr | GCY-20 signaling controls suppression of Caenorhabditis elegans egg laying by moderate cold |
| title_full_unstemmed | GCY-20 signaling controls suppression of Caenorhabditis elegans egg laying by moderate cold |
| title_short | GCY-20 signaling controls suppression of Caenorhabditis elegans egg laying by moderate cold |
| title_sort | gcy 20 signaling controls suppression of caenorhabditis elegans egg laying by moderate cold |
| topic | CP: Neuroscience |
| url | http://www.sciencedirect.com/science/article/pii/S2211124724000366 |
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