The anti-inflammatory effects of photobiomodulation are mediated by cytokines: Evidence from a mouse model of inflammation
There is an urgent need for therapeutic approaches that can prevent or limit neuroinflammatory processes and prevent neuronal degeneration. Photobiomodulation (PBM), the therapeutic use of specific wavelengths of light, is a safe approach shown to have anti-inflammatory effects. The current study wa...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-04-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2023.1150156/full |
| _version_ | 1797851344859561984 |
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| author | Shirin Shamloo Shirin Shamloo Erwin Defensor Erwin Defensor Peter Ciari Gaku Ogawa Laura Vidano Jennifer S. Lin Jennifer S. Lin John A. Fortkort Mehrdad Shamloo Annelise E. Barron |
| author_facet | Shirin Shamloo Shirin Shamloo Erwin Defensor Erwin Defensor Peter Ciari Gaku Ogawa Laura Vidano Jennifer S. Lin Jennifer S. Lin John A. Fortkort Mehrdad Shamloo Annelise E. Barron |
| author_sort | Shirin Shamloo |
| collection | DOAJ |
| description | There is an urgent need for therapeutic approaches that can prevent or limit neuroinflammatory processes and prevent neuronal degeneration. Photobiomodulation (PBM), the therapeutic use of specific wavelengths of light, is a safe approach shown to have anti-inflammatory effects. The current study was aimed at evaluating the effects of PBM on LPS-induced peripheral and central inflammation in mice to assess its potential as an anti-inflammatory treatment. Daily, 30-min treatment of mice with red/NIR light (RL) or RL with a 40 Hz gamma frequency flicker for 10 days prior to LPS challenge showed anti-inflammatory effects in the brain and systemically. PBM downregulated LPS induction of key proinflammatory cytokines associated with inflammasome activation, IL-1β and IL-18, and upregulated the anti-inflammatory cytokine, IL-10. RL provided robust anti-inflammatory effects, and the addition of gamma flicker potentiated these effects. Overall, these results demonstrate the potential of PBM as an anti-inflammatory treatment that acts through cytokine expression modulation. |
| first_indexed | 2024-04-09T19:16:23Z |
| format | Article |
| id | doaj.art-030edd5dba4a47a1b86d83183d76dda4 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-04-09T19:16:23Z |
| publishDate | 2023-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-030edd5dba4a47a1b86d83183d76dda42023-04-06T04:49:44ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2023-04-011710.3389/fnins.2023.11501561150156The anti-inflammatory effects of photobiomodulation are mediated by cytokines: Evidence from a mouse model of inflammationShirin Shamloo0Shirin Shamloo1Erwin Defensor2Erwin Defensor3Peter Ciari4Gaku Ogawa5Laura Vidano6Jennifer S. Lin7Jennifer S. Lin8John A. Fortkort9Mehrdad Shamloo10Annelise E. Barron11Department of Bioengineering, Schools of Medicine and Engineering, Stanford University, Stanford, CA, United StatesDepartment of Neurosurgery, School of Medicine, Stanford University, Stanford, CA, United StatesDepartment of Bioengineering, Schools of Medicine and Engineering, Stanford University, Stanford, CA, United StatesDepartment of Neurosurgery, School of Medicine, Stanford University, Stanford, CA, United StatesDepartment of Neurosurgery, School of Medicine, Stanford University, Stanford, CA, United StatesDepartment of Neurosurgery, School of Medicine, Stanford University, Stanford, CA, United StatesDepartment of Neurosurgery, School of Medicine, Stanford University, Stanford, CA, United StatesDepartment of Bioengineering, Schools of Medicine and Engineering, Stanford University, Stanford, CA, United StatesDepartment of Neurosurgery, School of Medicine, Stanford University, Stanford, CA, United StatesDepartment of Bioengineering, Schools of Medicine and Engineering, Stanford University, Stanford, CA, United StatesDepartment of Neurosurgery, School of Medicine, Stanford University, Stanford, CA, United StatesDepartment of Bioengineering, Schools of Medicine and Engineering, Stanford University, Stanford, CA, United StatesThere is an urgent need for therapeutic approaches that can prevent or limit neuroinflammatory processes and prevent neuronal degeneration. Photobiomodulation (PBM), the therapeutic use of specific wavelengths of light, is a safe approach shown to have anti-inflammatory effects. The current study was aimed at evaluating the effects of PBM on LPS-induced peripheral and central inflammation in mice to assess its potential as an anti-inflammatory treatment. Daily, 30-min treatment of mice with red/NIR light (RL) or RL with a 40 Hz gamma frequency flicker for 10 days prior to LPS challenge showed anti-inflammatory effects in the brain and systemically. PBM downregulated LPS induction of key proinflammatory cytokines associated with inflammasome activation, IL-1β and IL-18, and upregulated the anti-inflammatory cytokine, IL-10. RL provided robust anti-inflammatory effects, and the addition of gamma flicker potentiated these effects. Overall, these results demonstrate the potential of PBM as an anti-inflammatory treatment that acts through cytokine expression modulation.https://www.frontiersin.org/articles/10.3389/fnins.2023.1150156/fullphotobiomodulation (PBM)lipopolysaccharide (LPS)light therapyneuroinflammationsystemic inflammationneurodegenerative disorders |
| spellingShingle | Shirin Shamloo Shirin Shamloo Erwin Defensor Erwin Defensor Peter Ciari Gaku Ogawa Laura Vidano Jennifer S. Lin Jennifer S. Lin John A. Fortkort Mehrdad Shamloo Annelise E. Barron The anti-inflammatory effects of photobiomodulation are mediated by cytokines: Evidence from a mouse model of inflammation Frontiers in Neuroscience photobiomodulation (PBM) lipopolysaccharide (LPS) light therapy neuroinflammation systemic inflammation neurodegenerative disorders |
| title | The anti-inflammatory effects of photobiomodulation are mediated by cytokines: Evidence from a mouse model of inflammation |
| title_full | The anti-inflammatory effects of photobiomodulation are mediated by cytokines: Evidence from a mouse model of inflammation |
| title_fullStr | The anti-inflammatory effects of photobiomodulation are mediated by cytokines: Evidence from a mouse model of inflammation |
| title_full_unstemmed | The anti-inflammatory effects of photobiomodulation are mediated by cytokines: Evidence from a mouse model of inflammation |
| title_short | The anti-inflammatory effects of photobiomodulation are mediated by cytokines: Evidence from a mouse model of inflammation |
| title_sort | anti inflammatory effects of photobiomodulation are mediated by cytokines evidence from a mouse model of inflammation |
| topic | photobiomodulation (PBM) lipopolysaccharide (LPS) light therapy neuroinflammation systemic inflammation neurodegenerative disorders |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2023.1150156/full |
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