Untargeted Metabolomic Assay of Prefrail Older Adults after Nutritional Intervention
Frailty is a geriatric syndrome causing a reduction in the body’s functional reserves. Proper nutrition may be helpful in delaying transitioning older adults from pre-frail to frailty syndrome. The present study evaluates the nutritional status of pre-frail patients who underwent nutritional interve...
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MDPI AG
2022-04-01
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author | Alina Jaroch Mariusz Kozakiewicz Karol Jaroch Emilia Główczewska-Siedlecka Barbara Bojko Kornelia Kędziora-Kornatowska |
author_facet | Alina Jaroch Mariusz Kozakiewicz Karol Jaroch Emilia Główczewska-Siedlecka Barbara Bojko Kornelia Kędziora-Kornatowska |
author_sort | Alina Jaroch |
collection | DOAJ |
description | Frailty is a geriatric syndrome causing a reduction in the body’s functional reserves. Proper nutrition may be helpful in delaying transitioning older adults from pre-frail to frailty syndrome. The present study evaluates the nutritional status of pre-frail patients who underwent nutritional intervention and metabolomic changes resulting from this intervention. Sixteen pre-frail patients (68.4 ± 5.5 years old; 81.3% women) were enrolled for nutritional intervention, and twenty-nine robust elderly people (69.3 ± 5.3 years old; 82.8% women) were the control group. Pre-frail patients consumed 1.0 g protein/kg BW/day for eight weeks through diet modification and an additional daily intake of a protein powder formula. Taken measurements included: Nutritional anthropometry, assessment of food intake, and blood serum analysis with an untargeted metabolomic assessment. Protein consumption increased by 25.8%; moreover, significant increases in body weight (+1.2 kg; <i>p</i> = 0.023) and muscle mass index (+0.1 kg/m<sup>2</sup>; <i>p</i> = 0.042) were also observed. The untargeted metabolomic assay showed a significant increase in arachidonic acid (<i>p</i> = 0.038), and valine (<i>p</i> = 0.008) among pre-frail patients. Increased protein consumption is reflected in improved anthropometric and biochemical parameters of pre-frail patients. Moreover, metabolomic assay can be a useful tool in determining compliance with dietary recommendations. |
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issn | 2218-1989 |
language | English |
last_indexed | 2024-03-10T03:26:36Z |
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series | Metabolites |
spelling | doaj.art-030f5c1452fd403c9308c6f8980aaa162023-11-23T12:06:32ZengMDPI AGMetabolites2218-19892022-04-0112537810.3390/metabo12050378Untargeted Metabolomic Assay of Prefrail Older Adults after Nutritional InterventionAlina Jaroch0Mariusz Kozakiewicz1Karol Jaroch2Emilia Główczewska-Siedlecka3Barbara Bojko4Kornelia Kędziora-Kornatowska5Department of Nutrition and Dietetics, Faculty of Health Sciences, Nicolaus Copernicus University in Toruń, Ludwik Rydygier Collegium Medicum in Bydgoszcz, 85-626 Bydgoszcz, PolandDepartment of Geriatrics, Faculty of Health Sciences, Nicolaus Copernicus University in Toruń, Ludwik Rydygier Collegium Medicum in Bydgoszcz, 85-094 Bydgoszcz, PolandDepartment of Pharmacodynamics and Molecular Pharmacology, Faculty of Pharmacy, Nicolaus Copernicus University in Toruń, Ludwik Rydygier Collegium Medicum in Bydgoszcz, 85-089 Bydgoszcz, PolandDepartment of Geriatrics, Faculty of Health Sciences, Nicolaus Copernicus University in Toruń, Ludwik Rydygier Collegium Medicum in Bydgoszcz, 85-094 Bydgoszcz, PolandDepartment of Pharmacodynamics and Molecular Pharmacology, Faculty of Pharmacy, Nicolaus Copernicus University in Toruń, Ludwik Rydygier Collegium Medicum in Bydgoszcz, 85-089 Bydgoszcz, PolandDepartment of Geriatrics, Faculty of Health Sciences, Nicolaus Copernicus University in Toruń, Ludwik Rydygier Collegium Medicum in Bydgoszcz, 85-094 Bydgoszcz, PolandFrailty is a geriatric syndrome causing a reduction in the body’s functional reserves. Proper nutrition may be helpful in delaying transitioning older adults from pre-frail to frailty syndrome. The present study evaluates the nutritional status of pre-frail patients who underwent nutritional intervention and metabolomic changes resulting from this intervention. Sixteen pre-frail patients (68.4 ± 5.5 years old; 81.3% women) were enrolled for nutritional intervention, and twenty-nine robust elderly people (69.3 ± 5.3 years old; 82.8% women) were the control group. Pre-frail patients consumed 1.0 g protein/kg BW/day for eight weeks through diet modification and an additional daily intake of a protein powder formula. Taken measurements included: Nutritional anthropometry, assessment of food intake, and blood serum analysis with an untargeted metabolomic assessment. Protein consumption increased by 25.8%; moreover, significant increases in body weight (+1.2 kg; <i>p</i> = 0.023) and muscle mass index (+0.1 kg/m<sup>2</sup>; <i>p</i> = 0.042) were also observed. The untargeted metabolomic assay showed a significant increase in arachidonic acid (<i>p</i> = 0.038), and valine (<i>p</i> = 0.008) among pre-frail patients. Increased protein consumption is reflected in improved anthropometric and biochemical parameters of pre-frail patients. Moreover, metabolomic assay can be a useful tool in determining compliance with dietary recommendations.https://www.mdpi.com/2218-1989/12/5/378frailtynutritional statusmetabolomicsprotein consumptionSPME-LC-HRMS |
spellingShingle | Alina Jaroch Mariusz Kozakiewicz Karol Jaroch Emilia Główczewska-Siedlecka Barbara Bojko Kornelia Kędziora-Kornatowska Untargeted Metabolomic Assay of Prefrail Older Adults after Nutritional Intervention Metabolites frailty nutritional status metabolomics protein consumption SPME-LC-HRMS |
title | Untargeted Metabolomic Assay of Prefrail Older Adults after Nutritional Intervention |
title_full | Untargeted Metabolomic Assay of Prefrail Older Adults after Nutritional Intervention |
title_fullStr | Untargeted Metabolomic Assay of Prefrail Older Adults after Nutritional Intervention |
title_full_unstemmed | Untargeted Metabolomic Assay of Prefrail Older Adults after Nutritional Intervention |
title_short | Untargeted Metabolomic Assay of Prefrail Older Adults after Nutritional Intervention |
title_sort | untargeted metabolomic assay of prefrail older adults after nutritional intervention |
topic | frailty nutritional status metabolomics protein consumption SPME-LC-HRMS |
url | https://www.mdpi.com/2218-1989/12/5/378 |
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