Elevated exhaled acetone concentration in stage C heart failure patients with diabetes mellitus
Abstract Background Breath acetone is a noninvasive biomarker of heart failure; however, its significance in heart failure patients with diabetes mellitus has yet to be clarified. The objective of this study is to investigate whether exhaled acetone concentration is a noninvasive biomarker in heart...
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| Format: | Article |
| Language: | English |
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BMC
2017-11-01
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| Series: | BMC Cardiovascular Disorders |
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| Online Access: | http://link.springer.com/article/10.1186/s12872-017-0713-0 |
| _version_ | 1818448547579691008 |
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| author | Tetsuro Yokokawa Takamasa Sato Satoshi Suzuki Masayoshi Oikawa Akiomi Yoshihisa Atsushi Kobayashi Takayoshi Yamaki Hiroyuki Kunii Kazuhiko Nakazato Hitoshi Suzuki Shu-ichi Saitoh Takafumi Ishida Akito Shimouchi Yasuchika Takeishi |
| author_facet | Tetsuro Yokokawa Takamasa Sato Satoshi Suzuki Masayoshi Oikawa Akiomi Yoshihisa Atsushi Kobayashi Takayoshi Yamaki Hiroyuki Kunii Kazuhiko Nakazato Hitoshi Suzuki Shu-ichi Saitoh Takafumi Ishida Akito Shimouchi Yasuchika Takeishi |
| author_sort | Tetsuro Yokokawa |
| collection | DOAJ |
| description | Abstract Background Breath acetone is a noninvasive biomarker of heart failure; however, its significance in heart failure patients with diabetes mellitus has yet to be clarified. The objective of this study is to investigate whether exhaled acetone concentration is a noninvasive biomarker in heart failure patients with diabetes mellitus. Methods This study prospectively included 35 diabetic patients with stage C heart failure and 20 diabetic patients with or at risk of heart failure (stage A or B). Exhaled breath was collected after an overnight fast. Results The stage C group had significantly higher brain natriuretic peptide levels, larger left ventricular diameter, lower left ventricular ejection fraction, and more frequent use of β-blocker, compared with the stage A or B group. The stage C group had higher exhaled acetone concentrations than the stage A or B group (p = 0.013). Exhaled acetone concentration was correlated with total ketone bodies (r = 0.588, p < 0.001) and brain natriuretic peptide (r = 0.415, p = 0.002). Conclusion Stage C heart failure patients with diabetes mellitus have elevated exhaled acetone concentrations. Exhaled acetone concentration could be a noninvasive biomarker in heart failure patients with diabetes mellitus. |
| first_indexed | 2024-12-14T20:21:15Z |
| format | Article |
| id | doaj.art-0311e53845624ac09b8bb06a82373725 |
| institution | Directory Open Access Journal |
| issn | 1471-2261 |
| language | English |
| last_indexed | 2024-12-14T20:21:15Z |
| publishDate | 2017-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj.art-0311e53845624ac09b8bb06a823737252022-12-21T22:48:44ZengBMCBMC Cardiovascular Disorders1471-22612017-11-011711610.1186/s12872-017-0713-0Elevated exhaled acetone concentration in stage C heart failure patients with diabetes mellitusTetsuro Yokokawa0Takamasa Sato1Satoshi Suzuki2Masayoshi Oikawa3Akiomi Yoshihisa4Atsushi Kobayashi5Takayoshi Yamaki6Hiroyuki Kunii7Kazuhiko Nakazato8Hitoshi Suzuki9Shu-ichi Saitoh10Takafumi Ishida11Akito Shimouchi12Yasuchika Takeishi13Department of Cardiovascular Medicine, Fukushima Medical UniversityDepartment of Cardiovascular Medicine, Fukushima Medical UniversityDepartment of Cardiovascular Medicine, Fukushima Medical UniversityDepartment of Cardiovascular Medicine, Fukushima Medical UniversityDepartment of Cardiovascular Medicine, Fukushima Medical UniversityDepartment of Cardiovascular Medicine, Fukushima Medical UniversityDepartment of Cardiovascular Medicine, Fukushima Medical UniversityDepartment of Cardiovascular Medicine, Fukushima Medical UniversityDepartment of Cardiovascular Medicine, Fukushima Medical UniversityDepartment of Cardiovascular Medicine, Fukushima Medical UniversityDepartment of Cardiovascular Medicine, Fukushima Medical UniversityDepartment of Cardiovascular Medicine, Fukushima Medical UniversityDepartment of Lifelong Sports for Health Biochemical Sciences, College of Life and Health Sciences, Chubu UniversityDepartment of Cardiovascular Medicine, Fukushima Medical UniversityAbstract Background Breath acetone is a noninvasive biomarker of heart failure; however, its significance in heart failure patients with diabetes mellitus has yet to be clarified. The objective of this study is to investigate whether exhaled acetone concentration is a noninvasive biomarker in heart failure patients with diabetes mellitus. Methods This study prospectively included 35 diabetic patients with stage C heart failure and 20 diabetic patients with or at risk of heart failure (stage A or B). Exhaled breath was collected after an overnight fast. Results The stage C group had significantly higher brain natriuretic peptide levels, larger left ventricular diameter, lower left ventricular ejection fraction, and more frequent use of β-blocker, compared with the stage A or B group. The stage C group had higher exhaled acetone concentrations than the stage A or B group (p = 0.013). Exhaled acetone concentration was correlated with total ketone bodies (r = 0.588, p < 0.001) and brain natriuretic peptide (r = 0.415, p = 0.002). Conclusion Stage C heart failure patients with diabetes mellitus have elevated exhaled acetone concentrations. Exhaled acetone concentration could be a noninvasive biomarker in heart failure patients with diabetes mellitus.http://link.springer.com/article/10.1186/s12872-017-0713-0AcetoneBreath analysisHeart failureDiabetes mellitus |
| spellingShingle | Tetsuro Yokokawa Takamasa Sato Satoshi Suzuki Masayoshi Oikawa Akiomi Yoshihisa Atsushi Kobayashi Takayoshi Yamaki Hiroyuki Kunii Kazuhiko Nakazato Hitoshi Suzuki Shu-ichi Saitoh Takafumi Ishida Akito Shimouchi Yasuchika Takeishi Elevated exhaled acetone concentration in stage C heart failure patients with diabetes mellitus BMC Cardiovascular Disorders Acetone Breath analysis Heart failure Diabetes mellitus |
| title | Elevated exhaled acetone concentration in stage C heart failure patients with diabetes mellitus |
| title_full | Elevated exhaled acetone concentration in stage C heart failure patients with diabetes mellitus |
| title_fullStr | Elevated exhaled acetone concentration in stage C heart failure patients with diabetes mellitus |
| title_full_unstemmed | Elevated exhaled acetone concentration in stage C heart failure patients with diabetes mellitus |
| title_short | Elevated exhaled acetone concentration in stage C heart failure patients with diabetes mellitus |
| title_sort | elevated exhaled acetone concentration in stage c heart failure patients with diabetes mellitus |
| topic | Acetone Breath analysis Heart failure Diabetes mellitus |
| url | http://link.springer.com/article/10.1186/s12872-017-0713-0 |
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