The influence of adalimumab treatment on the systemic gene expression in patients with psoriatic arthritis – preliminary report
Introduction The primary goal of psoriasis treatment is to reduce the inflammatory response and associated complications. In severe cases of psoriasis that are resistant to local treatment (e.g., keratolytic preparations) and at least two types of general treatment methods (e.g., retinoids and cyclo...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Termedia Publishing House
2021-03-01
|
| Series: | Archives of Medical Science |
| Subjects: | |
| Online Access: | https://www.archivesofmedicalscience.com/The-influence-of-adalimumab-treatment-on-the-systemic-gene-expression-in-patients,113027,0,2.html |
| _version_ | 1797435429985714176 |
|---|---|
| author | Agata Krawczyk Barbara Strzałka-Mrozik Dominika Wcisło-Dziadecka Magdalena Kimsa-Dudek Celina Kruszniewska-Rajsa Joanna Gola |
| author_facet | Agata Krawczyk Barbara Strzałka-Mrozik Dominika Wcisło-Dziadecka Magdalena Kimsa-Dudek Celina Kruszniewska-Rajsa Joanna Gola |
| author_sort | Agata Krawczyk |
| collection | DOAJ |
| description | Introduction
The primary goal of psoriasis treatment is to reduce the inflammatory response and associated complications. In severe cases of psoriasis that are resistant to local treatment (e.g., keratolytic preparations) and at least two types of general treatment methods (e.g., retinoids and cyclosporine A), biological therapy is used. This study aimed to assess the systemic effects of adalimumab at a given stage of treatment in patients with psoriatic arthritis and evaluate how the drug can improve the clinical condition of the patients.
Material and methods
The study group consisted of patients with diagnosed psoriatic arthritis, while the control group consisted of individuals from whom peripheral blood mononuclear cells were obtained. The effects of the administration of adalimumab were assessed by analyzing the gene expression using oligonucleotide microarrays.
Results
The apoptosis process was found to be one of the overrepresented categories (the PANTHER classification system 13.1 program, overrepresentation test, p < 0.05). The dermatological indexes decreased, indicating an improvement in the clinical conditions of the patients 3 months after the first dose of adalimumab.
Conclusions
We found that adalimumab affects apoptosis, which is crucial in the development and course of psoriasis. The differential gene expression in peripheral blood mononuclear cells of patients with psoriatic arthritis indicated the potential systemic effects of adalimumab therapy. The analyses of dermatological (the Psoriasis Area and Severity Index, body surface area and Dermatology Life Quality Index) and inflammatory (Biernacki’s reaction) parameters revealed the effectiveness of the therapy. |
| first_indexed | 2024-03-09T10:47:01Z |
| format | Article |
| id | doaj.art-0312205a0d8943089cf02c63605fac0a |
| institution | Directory Open Access Journal |
| issn | 1734-1922 1896-9151 |
| language | English |
| last_indexed | 2024-03-09T10:47:01Z |
| publishDate | 2021-03-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Archives of Medical Science |
| spelling | doaj.art-0312205a0d8943089cf02c63605fac0a2023-12-01T09:50:30ZengTermedia Publishing HouseArchives of Medical Science1734-19221896-91512021-03-011941080109110.5114/aoms/113027113027The influence of adalimumab treatment on the systemic gene expression in patients with psoriatic arthritis – preliminary reportAgata Krawczyk0Barbara Strzałka-Mrozik1Dominika Wcisło-Dziadecka2Magdalena Kimsa-Dudek3Celina Kruszniewska-Rajsa4Joanna Gola5Department of Nutrigenomics and Bromatology, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, PolandDepartment of Nutrigenomics and Bromatology, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, PolandDepartment of Cosmetology, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, PolandDepartment of Nutrigenomics and Bromatology, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, PolandDepartment of Nutrigenomics and Bromatology, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, PolandDepartment of Nutrigenomics and Bromatology, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, PolandIntroduction The primary goal of psoriasis treatment is to reduce the inflammatory response and associated complications. In severe cases of psoriasis that are resistant to local treatment (e.g., keratolytic preparations) and at least two types of general treatment methods (e.g., retinoids and cyclosporine A), biological therapy is used. This study aimed to assess the systemic effects of adalimumab at a given stage of treatment in patients with psoriatic arthritis and evaluate how the drug can improve the clinical condition of the patients. Material and methods The study group consisted of patients with diagnosed psoriatic arthritis, while the control group consisted of individuals from whom peripheral blood mononuclear cells were obtained. The effects of the administration of adalimumab were assessed by analyzing the gene expression using oligonucleotide microarrays. Results The apoptosis process was found to be one of the overrepresented categories (the PANTHER classification system 13.1 program, overrepresentation test, p < 0.05). The dermatological indexes decreased, indicating an improvement in the clinical conditions of the patients 3 months after the first dose of adalimumab. Conclusions We found that adalimumab affects apoptosis, which is crucial in the development and course of psoriasis. The differential gene expression in peripheral blood mononuclear cells of patients with psoriatic arthritis indicated the potential systemic effects of adalimumab therapy. The analyses of dermatological (the Psoriasis Area and Severity Index, body surface area and Dermatology Life Quality Index) and inflammatory (Biernacki’s reaction) parameters revealed the effectiveness of the therapy.https://www.archivesofmedicalscience.com/The-influence-of-adalimumab-treatment-on-the-systemic-gene-expression-in-patients,113027,0,2.htmlbiological treatmentapoptosisautoimmune diseasepsoriatic arthritis |
| spellingShingle | Agata Krawczyk Barbara Strzałka-Mrozik Dominika Wcisło-Dziadecka Magdalena Kimsa-Dudek Celina Kruszniewska-Rajsa Joanna Gola The influence of adalimumab treatment on the systemic gene expression in patients with psoriatic arthritis – preliminary report Archives of Medical Science biological treatment apoptosis autoimmune disease psoriatic arthritis |
| title | The influence of adalimumab treatment on the systemic gene expression in patients with psoriatic arthritis – preliminary report |
| title_full | The influence of adalimumab treatment on the systemic gene expression in patients with psoriatic arthritis – preliminary report |
| title_fullStr | The influence of adalimumab treatment on the systemic gene expression in patients with psoriatic arthritis – preliminary report |
| title_full_unstemmed | The influence of adalimumab treatment on the systemic gene expression in patients with psoriatic arthritis – preliminary report |
| title_short | The influence of adalimumab treatment on the systemic gene expression in patients with psoriatic arthritis – preliminary report |
| title_sort | influence of adalimumab treatment on the systemic gene expression in patients with psoriatic arthritis preliminary report |
| topic | biological treatment apoptosis autoimmune disease psoriatic arthritis |
| url | https://www.archivesofmedicalscience.com/The-influence-of-adalimumab-treatment-on-the-systemic-gene-expression-in-patients,113027,0,2.html |
| work_keys_str_mv | AT agatakrawczyk theinfluenceofadalimumabtreatmentonthesystemicgeneexpressioninpatientswithpsoriaticarthritispreliminaryreport AT barbarastrzałkamrozik theinfluenceofadalimumabtreatmentonthesystemicgeneexpressioninpatientswithpsoriaticarthritispreliminaryreport AT dominikawcisłodziadecka theinfluenceofadalimumabtreatmentonthesystemicgeneexpressioninpatientswithpsoriaticarthritispreliminaryreport AT magdalenakimsadudek theinfluenceofadalimumabtreatmentonthesystemicgeneexpressioninpatientswithpsoriaticarthritispreliminaryreport AT celinakruszniewskarajsa theinfluenceofadalimumabtreatmentonthesystemicgeneexpressioninpatientswithpsoriaticarthritispreliminaryreport AT joannagola theinfluenceofadalimumabtreatmentonthesystemicgeneexpressioninpatientswithpsoriaticarthritispreliminaryreport AT agatakrawczyk influenceofadalimumabtreatmentonthesystemicgeneexpressioninpatientswithpsoriaticarthritispreliminaryreport AT barbarastrzałkamrozik influenceofadalimumabtreatmentonthesystemicgeneexpressioninpatientswithpsoriaticarthritispreliminaryreport AT dominikawcisłodziadecka influenceofadalimumabtreatmentonthesystemicgeneexpressioninpatientswithpsoriaticarthritispreliminaryreport AT magdalenakimsadudek influenceofadalimumabtreatmentonthesystemicgeneexpressioninpatientswithpsoriaticarthritispreliminaryreport AT celinakruszniewskarajsa influenceofadalimumabtreatmentonthesystemicgeneexpressioninpatientswithpsoriaticarthritispreliminaryreport AT joannagola influenceofadalimumabtreatmentonthesystemicgeneexpressioninpatientswithpsoriaticarthritispreliminaryreport |