Drug discovery inspired by bioactive small molecules from nature
ABSTRACTNatural products (NPs) have greatly contributed to the development of novel treatments for human diseases such as cancer, metabolic disorders, and infections. Compared to synthetic chemical compounds, primary and secondary metabolites from medicinal plants, fungi, microorganisms, and our bod...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2022-11-01
|
| Series: | Animal Cells and Systems |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/19768354.2022.2157480 |
| _version_ | 1797815411865026560 |
|---|---|
| author | Seyun Kim Seol-Wa Lim Jiyeon Choi |
| author_facet | Seyun Kim Seol-Wa Lim Jiyeon Choi |
| author_sort | Seyun Kim |
| collection | DOAJ |
| description | ABSTRACTNatural products (NPs) have greatly contributed to the development of novel treatments for human diseases such as cancer, metabolic disorders, and infections. Compared to synthetic chemical compounds, primary and secondary metabolites from medicinal plants, fungi, microorganisms, and our bodies are promising resources with immense chemical diversity and favorable properties for drug development. In addition to the well-validated significance of secondary metabolites, endogenous small molecules derived from central metabolism and signaling events have shown great potential as drug candidates due to their unique metabolite-protein interactions. In this short review, we highlight the values of NPs, discuss recent scientific and technological advances including metabolomics tools, chemoproteomics approaches, and artificial intelligence-based computation platforms, and explore potential strategies to overcome the current challenges in NP-driven drug discovery. |
| first_indexed | 2024-03-13T08:22:17Z |
| format | Article |
| id | doaj.art-03123fea2c264c38967525dd3179e43c |
| institution | Directory Open Access Journal |
| issn | 1976-8354 2151-2485 |
| language | English |
| last_indexed | 2024-03-13T08:22:17Z |
| publishDate | 2022-11-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Animal Cells and Systems |
| spelling | doaj.art-03123fea2c264c38967525dd3179e43c2023-05-31T05:33:12ZengTaylor & Francis GroupAnimal Cells and Systems1976-83542151-24852022-11-0126625426510.1080/19768354.2022.2157480Drug discovery inspired by bioactive small molecules from natureSeyun Kim0Seol-Wa Lim1Jiyeon Choi2Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of KoreaDepartment of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of KoreaDepartment of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of KoreaABSTRACTNatural products (NPs) have greatly contributed to the development of novel treatments for human diseases such as cancer, metabolic disorders, and infections. Compared to synthetic chemical compounds, primary and secondary metabolites from medicinal plants, fungi, microorganisms, and our bodies are promising resources with immense chemical diversity and favorable properties for drug development. In addition to the well-validated significance of secondary metabolites, endogenous small molecules derived from central metabolism and signaling events have shown great potential as drug candidates due to their unique metabolite-protein interactions. In this short review, we highlight the values of NPs, discuss recent scientific and technological advances including metabolomics tools, chemoproteomics approaches, and artificial intelligence-based computation platforms, and explore potential strategies to overcome the current challenges in NP-driven drug discovery.https://www.tandfonline.com/doi/10.1080/19768354.2022.2157480Natural productdrug discoverymetabolitecell signalingmetabolomics |
| spellingShingle | Seyun Kim Seol-Wa Lim Jiyeon Choi Drug discovery inspired by bioactive small molecules from nature Animal Cells and Systems Natural product drug discovery metabolite cell signaling metabolomics |
| title | Drug discovery inspired by bioactive small molecules from nature |
| title_full | Drug discovery inspired by bioactive small molecules from nature |
| title_fullStr | Drug discovery inspired by bioactive small molecules from nature |
| title_full_unstemmed | Drug discovery inspired by bioactive small molecules from nature |
| title_short | Drug discovery inspired by bioactive small molecules from nature |
| title_sort | drug discovery inspired by bioactive small molecules from nature |
| topic | Natural product drug discovery metabolite cell signaling metabolomics |
| url | https://www.tandfonline.com/doi/10.1080/19768354.2022.2157480 |
| work_keys_str_mv | AT seyunkim drugdiscoveryinspiredbybioactivesmallmoleculesfromnature AT seolwalim drugdiscoveryinspiredbybioactivesmallmoleculesfromnature AT jiyeonchoi drugdiscoveryinspiredbybioactivesmallmoleculesfromnature |