Intraoperative haloperidol does not improve quality of recovery and postoperative analgesia
Introduction: Haloperidol has an established role in nausea and vomiting prophylaxis and possible effects on multiple aspects of postoperative recovery including pain and sedation. The purpose of this study was to evaluate the effects of low-dose intraoperative intravenous haloperidol on quality of...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2013-01-01
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| Series: | Advanced Biomedical Research |
| Subjects: | |
| Online Access: | http://www.advbiores.net/article.asp?issn=2277-9175;year=2013;volume=2;issue=1;spage=85;epage=85;aulast=Ebneshahidi |
| _version_ | 1798043735150297088 |
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| author | Amin Ebneshahidi Mojtaba Akbari Masood Mohseni |
| author_facet | Amin Ebneshahidi Mojtaba Akbari Masood Mohseni |
| author_sort | Amin Ebneshahidi |
| collection | DOAJ |
| description | Introduction: Haloperidol has an established role in nausea and vomiting prophylaxis and possible effects on multiple aspects of postoperative recovery including pain and sedation. The purpose of this study was to evaluate the effects of low-dose intraoperative intravenous haloperidol on quality of recovery (QoR) and pain control after general anesthesia and surgery.
Methods: Ninety eight American Society of Anesthesiologists (ASA) physical status I-II patients undergoing elective general, gynecologic or orthopedic surgery under general anesthesia were enrolled. Participants were randomly allocated to receive either haloperidol 2 mg or sterile water intravenously after induction of anesthesia. All patients were given elastometric morphine patient-controlled analgesia (PCA) pump for pain control after the surgery. Post-operative QoR was evaluated within 20 min in the recovery room and 6 h post-operatively. Pain intensity and demand for additional analgesic was measured in the 6 th post-operative hour.
Results: The QoR score in two measurements was not statistically different between the two groups. Haloperidol significantly reduced the nausea in the recovery. The visual analog scale pain score showed that the severity of pain in the haloperidol group was more than the placebo group (4.7 ± 2.4 vs. 3.8 ± 2.5, P = 0.05).
Conclusion: Intraoperative small-dose IV haloperidol is effective against post-operative nausea and vomiting with no significant effect on overall QoR. It may also attenuate the analgesic effects of morphine PCA. |
| first_indexed | 2024-04-11T22:53:15Z |
| format | Article |
| id | doaj.art-03133a555ada4222973e7d20ccf97447 |
| institution | Directory Open Access Journal |
| issn | 2277-9175 2277-9175 |
| language | English |
| last_indexed | 2024-04-11T22:53:15Z |
| publishDate | 2013-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Advanced Biomedical Research |
| spelling | doaj.art-03133a555ada4222973e7d20ccf974472022-12-22T03:58:31ZengWolters Kluwer Medknow PublicationsAdvanced Biomedical Research2277-91752277-91752013-01-0121858510.4103/2277-9175.122501Intraoperative haloperidol does not improve quality of recovery and postoperative analgesiaAmin EbneshahidiMojtaba AkbariMasood MohseniIntroduction: Haloperidol has an established role in nausea and vomiting prophylaxis and possible effects on multiple aspects of postoperative recovery including pain and sedation. The purpose of this study was to evaluate the effects of low-dose intraoperative intravenous haloperidol on quality of recovery (QoR) and pain control after general anesthesia and surgery. Methods: Ninety eight American Society of Anesthesiologists (ASA) physical status I-II patients undergoing elective general, gynecologic or orthopedic surgery under general anesthesia were enrolled. Participants were randomly allocated to receive either haloperidol 2 mg or sterile water intravenously after induction of anesthesia. All patients were given elastometric morphine patient-controlled analgesia (PCA) pump for pain control after the surgery. Post-operative QoR was evaluated within 20 min in the recovery room and 6 h post-operatively. Pain intensity and demand for additional analgesic was measured in the 6 th post-operative hour. Results: The QoR score in two measurements was not statistically different between the two groups. Haloperidol significantly reduced the nausea in the recovery. The visual analog scale pain score showed that the severity of pain in the haloperidol group was more than the placebo group (4.7 ± 2.4 vs. 3.8 ± 2.5, P = 0.05). Conclusion: Intraoperative small-dose IV haloperidol is effective against post-operative nausea and vomiting with no significant effect on overall QoR. It may also attenuate the analgesic effects of morphine PCA.http://www.advbiores.net/article.asp?issn=2277-9175;year=2013;volume=2;issue=1;spage=85;epage=85;aulast=EbneshahidiHaloperidolnauseapainquality of recoveryrandomized clinical trial |
| spellingShingle | Amin Ebneshahidi Mojtaba Akbari Masood Mohseni Intraoperative haloperidol does not improve quality of recovery and postoperative analgesia Advanced Biomedical Research Haloperidol nausea pain quality of recovery randomized clinical trial |
| title | Intraoperative haloperidol does not improve quality of recovery and postoperative analgesia |
| title_full | Intraoperative haloperidol does not improve quality of recovery and postoperative analgesia |
| title_fullStr | Intraoperative haloperidol does not improve quality of recovery and postoperative analgesia |
| title_full_unstemmed | Intraoperative haloperidol does not improve quality of recovery and postoperative analgesia |
| title_short | Intraoperative haloperidol does not improve quality of recovery and postoperative analgesia |
| title_sort | intraoperative haloperidol does not improve quality of recovery and postoperative analgesia |
| topic | Haloperidol nausea pain quality of recovery randomized clinical trial |
| url | http://www.advbiores.net/article.asp?issn=2277-9175;year=2013;volume=2;issue=1;spage=85;epage=85;aulast=Ebneshahidi |
| work_keys_str_mv | AT aminebneshahidi intraoperativehaloperidoldoesnotimprovequalityofrecoveryandpostoperativeanalgesia AT mojtabaakbari intraoperativehaloperidoldoesnotimprovequalityofrecoveryandpostoperativeanalgesia AT masoodmohseni intraoperativehaloperidoldoesnotimprovequalityofrecoveryandpostoperativeanalgesia |