Concerted conformational dynamics and water movements in the ghrelin G protein-coupled receptor

Concerted conformational dynamics and water movements in the ghrelin G protein-coupled receptor

There is increasing support for water molecules playing a role in signal propagation through G protein-coupled receptors (GPCRs). However, exploration of the hydration features of GPCRs is still in its infancy. Here, we combined site-specific labeling with unnatural amino acids to molecular dynamics...

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Bibliographic Details
Main Authors: Maxime Louet, Marina Casiraghi, Marjorie Damian, Mauricio GS Costa, Pedro Renault, Antoniel AS Gomes, Paulo R Batista, Céline M'Kadmi, Sophie Mary, Sonia Cantel, Severine Denoyelle, Khoubaib Ben Haj Salah, David Perahia, Paulo M Bisch, Jean-Alain Fehrentz, Laurent J Catoire, Nicolas Floquet, Jean-Louis Banères
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-09-01
Series:eLife
Subjects:
GPCR
hydration
signaling
Online Access:https://elifesciences.org/articles/63201

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