Glycerophosphate/Acylglycerophosphate Acyltransferases
Acyl-CoA:glycerol-3-phosphate acyltransferase (GPAT) and acyl-CoA: 1-acyl-glycerol-3-phosphate acyltransferase (AGPAT) are involved in the de novo synthesis of triacylglycerol (TAG) and glycerophospholipids. Many enzymes belonging to the GPAT/AGPAT family have recently been identified and their phy...
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| Format: | Article |
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MDPI AG
2014-11-01
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| Series: | Biology |
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| Online Access: | http://www.mdpi.com/2079-7737/3/4/801 |
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| author | Atsushi Yamashita Yasuhiro Hayashi Naoki Matsumoto Yoko Nemoto-Sasaki Saori Oka Takashi Tanikawa Takayuki Sugiura |
| author_facet | Atsushi Yamashita Yasuhiro Hayashi Naoki Matsumoto Yoko Nemoto-Sasaki Saori Oka Takashi Tanikawa Takayuki Sugiura |
| author_sort | Atsushi Yamashita |
| collection | DOAJ |
| description | Acyl-CoA:glycerol-3-phosphate acyltransferase (GPAT) and acyl-CoA: 1-acyl-glycerol-3-phosphate acyltransferase (AGPAT) are involved in the de novo synthesis of triacylglycerol (TAG) and glycerophospholipids. Many enzymes belonging to the GPAT/AGPAT family have recently been identified and their physiological or pathophysiological roles have been proposed. The roles of GPAT/AGPAT in the synthesis of TAG and obesity-related diseases were revealed through the identification of causative genes of these diseases or analyses of genetically manipulated animals. Recent studies have suggested that some isoforms of GPAT/AGPAT family enzymes are involved in the fatty acid remodeling of phospholipids. The enzymology of GPAT/AGPAT and their physiological/ pathological roles in the metabolism of glycerolipids have been described and discussed in this review. |
| first_indexed | 2024-03-12T04:41:34Z |
| format | Article |
| id | doaj.art-0318de84059841a9a10d04647a8ffe84 |
| institution | Directory Open Access Journal |
| issn | 2079-7737 |
| language | English |
| last_indexed | 2024-03-12T04:41:34Z |
| publishDate | 2014-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology |
| spelling | doaj.art-0318de84059841a9a10d04647a8ffe842023-09-03T09:37:48ZengMDPI AGBiology2079-77372014-11-013480183010.3390/biology3040801biology3040801Glycerophosphate/Acylglycerophosphate AcyltransferasesAtsushi Yamashita0Yasuhiro Hayashi1Naoki Matsumoto2Yoko Nemoto-Sasaki3Saori Oka4Takashi Tanikawa5Takayuki Sugiura6Faculty of Pharma-Sciences, Teikyo University, 2-11-1 Kaga, Itabashi-Ku, Tokyo 173-8605, JapanFaculty of Pharma-Sciences, Teikyo University, 2-11-1 Kaga, Itabashi-Ku, Tokyo 173-8605, JapanFaculty of Pharma-Sciences, Teikyo University, 2-11-1 Kaga, Itabashi-Ku, Tokyo 173-8605, JapanFaculty of Pharma-Sciences, Teikyo University, 2-11-1 Kaga, Itabashi-Ku, Tokyo 173-8605, JapanFaculty of Pharma-Sciences, Teikyo University, 2-11-1 Kaga, Itabashi-Ku, Tokyo 173-8605, JapanFaculty of Pharma-Sciences, Teikyo University, 2-11-1 Kaga, Itabashi-Ku, Tokyo 173-8605, JapanFaculty of Pharma-Sciences, Teikyo University, 2-11-1 Kaga, Itabashi-Ku, Tokyo 173-8605, JapanAcyl-CoA:glycerol-3-phosphate acyltransferase (GPAT) and acyl-CoA: 1-acyl-glycerol-3-phosphate acyltransferase (AGPAT) are involved in the de novo synthesis of triacylglycerol (TAG) and glycerophospholipids. Many enzymes belonging to the GPAT/AGPAT family have recently been identified and their physiological or pathophysiological roles have been proposed. The roles of GPAT/AGPAT in the synthesis of TAG and obesity-related diseases were revealed through the identification of causative genes of these diseases or analyses of genetically manipulated animals. Recent studies have suggested that some isoforms of GPAT/AGPAT family enzymes are involved in the fatty acid remodeling of phospholipids. The enzymology of GPAT/AGPAT and their physiological/ pathological roles in the metabolism of glycerolipids have been described and discussed in this review.http://www.mdpi.com/2079-7737/3/4/801acyltransferaseacyl-CoAtriacylglycerolphospholipidGPATAGPAT |
| spellingShingle | Atsushi Yamashita Yasuhiro Hayashi Naoki Matsumoto Yoko Nemoto-Sasaki Saori Oka Takashi Tanikawa Takayuki Sugiura Glycerophosphate/Acylglycerophosphate Acyltransferases Biology acyltransferase acyl-CoA triacylglycerol phospholipid GPAT AGPAT |
| title | Glycerophosphate/Acylglycerophosphate Acyltransferases |
| title_full | Glycerophosphate/Acylglycerophosphate Acyltransferases |
| title_fullStr | Glycerophosphate/Acylglycerophosphate Acyltransferases |
| title_full_unstemmed | Glycerophosphate/Acylglycerophosphate Acyltransferases |
| title_short | Glycerophosphate/Acylglycerophosphate Acyltransferases |
| title_sort | glycerophosphate acylglycerophosphate acyltransferases |
| topic | acyltransferase acyl-CoA triacylglycerol phospholipid GPAT AGPAT |
| url | http://www.mdpi.com/2079-7737/3/4/801 |
| work_keys_str_mv | AT atsushiyamashita glycerophosphateacylglycerophosphateacyltransferases AT yasuhirohayashi glycerophosphateacylglycerophosphateacyltransferases AT naokimatsumoto glycerophosphateacylglycerophosphateacyltransferases AT yokonemotosasaki glycerophosphateacylglycerophosphateacyltransferases AT saorioka glycerophosphateacylglycerophosphateacyltransferases AT takashitanikawa glycerophosphateacylglycerophosphateacyltransferases AT takayukisugiura glycerophosphateacylglycerophosphateacyltransferases |