A senataxin-associated exonuclease SAN1 is required for resistance to DNA interstrand cross-links
When DNA interstrand cross-links damage occurs, it causes disruption of replication and transcription. Here the authors identify FAM120B/SAN1, a 5′ exonuclease involved in the repair process of Interstrand Crosslinks independently of the Fanconi Anemia pathway.
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2018-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-05008-8 |
| _version_ | 1818341770759503872 |
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| author | Alex M. Andrews Heather J. McCartney Tim M. Errington Alan D. D’Andrea Ian G. Macara |
| author_facet | Alex M. Andrews Heather J. McCartney Tim M. Errington Alan D. D’Andrea Ian G. Macara |
| author_sort | Alex M. Andrews |
| collection | DOAJ |
| description | When DNA interstrand cross-links damage occurs, it causes disruption of replication and transcription. Here the authors identify FAM120B/SAN1, a 5′ exonuclease involved in the repair process of Interstrand Crosslinks independently of the Fanconi Anemia pathway. |
| first_indexed | 2024-12-13T16:04:05Z |
| format | Article |
| id | doaj.art-031ac7b17c8c4e12a4254e48a3e6d6a6 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-13T16:04:05Z |
| publishDate | 2018-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-031ac7b17c8c4e12a4254e48a3e6d6a62022-12-21T23:39:05ZengNature PortfolioNature Communications2041-17232018-07-019111610.1038/s41467-018-05008-8A senataxin-associated exonuclease SAN1 is required for resistance to DNA interstrand cross-linksAlex M. Andrews0Heather J. McCartney1Tim M. Errington2Alan D. D’Andrea3Ian G. Macara4Department of Cell and Developmental Biology, Vanderbilt University School of MedicineDepartment of Cell and Developmental Biology, Vanderbilt University School of MedicineDepartment of Microbiology, Immunology and Cancer Biology, University of VirginiaDana-Farber Cancer Institute, Harvard Medical SchoolDepartment of Cell and Developmental Biology, Vanderbilt University School of MedicineWhen DNA interstrand cross-links damage occurs, it causes disruption of replication and transcription. Here the authors identify FAM120B/SAN1, a 5′ exonuclease involved in the repair process of Interstrand Crosslinks independently of the Fanconi Anemia pathway.https://doi.org/10.1038/s41467-018-05008-8 |
| spellingShingle | Alex M. Andrews Heather J. McCartney Tim M. Errington Alan D. D’Andrea Ian G. Macara A senataxin-associated exonuclease SAN1 is required for resistance to DNA interstrand cross-links Nature Communications |
| title | A senataxin-associated exonuclease SAN1 is required for resistance to DNA interstrand cross-links |
| title_full | A senataxin-associated exonuclease SAN1 is required for resistance to DNA interstrand cross-links |
| title_fullStr | A senataxin-associated exonuclease SAN1 is required for resistance to DNA interstrand cross-links |
| title_full_unstemmed | A senataxin-associated exonuclease SAN1 is required for resistance to DNA interstrand cross-links |
| title_short | A senataxin-associated exonuclease SAN1 is required for resistance to DNA interstrand cross-links |
| title_sort | senataxin associated exonuclease san1 is required for resistance to dna interstrand cross links |
| url | https://doi.org/10.1038/s41467-018-05008-8 |
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