Short Stature Diagnosis and Referral
The “360° GH in Europe” meeting, which examined various aspects of GH diseases, was held in Lisbon, Portugal, in June 2016. The Merck KGaA (Germany) funded meeting comprised three sessions entitled “Short Stature Diagnosis and Referral,” “Optimizing Patient Management,” and “Managing Transition.” Ea...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-01-01
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| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/article/10.3389/fendo.2017.00374/full |
| _version_ | 1818467035328282624 |
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| author | Mohamad Maghnie José I. Labarta Ekaterina Koledova Tilman R. Rohrer |
| author_facet | Mohamad Maghnie José I. Labarta Ekaterina Koledova Tilman R. Rohrer |
| author_sort | Mohamad Maghnie |
| collection | DOAJ |
| description | The “360° GH in Europe” meeting, which examined various aspects of GH diseases, was held in Lisbon, Portugal, in June 2016. The Merck KGaA (Germany) funded meeting comprised three sessions entitled “Short Stature Diagnosis and Referral,” “Optimizing Patient Management,” and “Managing Transition.” Each session had three speaker presentations, followed by a discussion period, and is reported as a manuscript, authored by the speakers. The first session examined current processes of diagnosis and referral by endocrine specialists for pediatric patients with short stature. Requirements for referral vary widely, by country and by patient characteristics such as age. A balance must be made to ensure eligible patients get referred while healthcare systems are not over-burdened by excessive referrals. Late referral and diagnosis of non-GH deficiency conditions can result in increased morbidity and mortality. The consequent delays in making a diagnosis may compromise the effectiveness of GH treatment. Algorithms for growth monitoring and evaluation of skeletal disproportions can improve identification of non-GH deficiency conditions. Performance and validation of guidelines for diagnosis of GH deficiency have not been sufficiently tested. Provocative tests for investigation of GH deficiency remain equivocal, with insufficient information on variations due to patient characteristics, and cutoff values for definition differ not only by country but also by the assay used. When referring and diagnosing causes of short stature in pediatric patients, clinicians need to rely on many factors, but the most essential is clinical experience. |
| first_indexed | 2024-04-13T21:04:16Z |
| format | Article |
| id | doaj.art-031b7c77ae274d3da698bb0e424a8708 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-13T21:04:16Z |
| publishDate | 2018-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-031b7c77ae274d3da698bb0e424a87082022-12-22T02:30:02ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922018-01-01810.3389/fendo.2017.00374298133Short Stature Diagnosis and ReferralMohamad Maghnie0José I. Labarta1Ekaterina Koledova2Tilman R. Rohrer3Department of Pediatrics, IRCCS Children’s Hospital Giannina Gaslini, University of Genoa, Genoa, ItalyEndocrinology Unit, Children’s Hospital Miguel Servet, University of Zaragoza, Zaragoza, SpainGlobal Medical Affairs, Merck KGaA, Darmstadt, GermanyDepartment of Pediatrics, Saarland University Medical Center, Homburg, GermanyThe “360° GH in Europe” meeting, which examined various aspects of GH diseases, was held in Lisbon, Portugal, in June 2016. The Merck KGaA (Germany) funded meeting comprised three sessions entitled “Short Stature Diagnosis and Referral,” “Optimizing Patient Management,” and “Managing Transition.” Each session had three speaker presentations, followed by a discussion period, and is reported as a manuscript, authored by the speakers. The first session examined current processes of diagnosis and referral by endocrine specialists for pediatric patients with short stature. Requirements for referral vary widely, by country and by patient characteristics such as age. A balance must be made to ensure eligible patients get referred while healthcare systems are not over-burdened by excessive referrals. Late referral and diagnosis of non-GH deficiency conditions can result in increased morbidity and mortality. The consequent delays in making a diagnosis may compromise the effectiveness of GH treatment. Algorithms for growth monitoring and evaluation of skeletal disproportions can improve identification of non-GH deficiency conditions. Performance and validation of guidelines for diagnosis of GH deficiency have not been sufficiently tested. Provocative tests for investigation of GH deficiency remain equivocal, with insufficient information on variations due to patient characteristics, and cutoff values for definition differ not only by country but also by the assay used. When referring and diagnosing causes of short stature in pediatric patients, clinicians need to rely on many factors, but the most essential is clinical experience.http://journal.frontiersin.org/article/10.3389/fendo.2017.00374/fullgrowth hormoneshort staturediagnosisreferralpatient management |
| spellingShingle | Mohamad Maghnie José I. Labarta Ekaterina Koledova Tilman R. Rohrer Short Stature Diagnosis and Referral Frontiers in Endocrinology growth hormone short stature diagnosis referral patient management |
| title | Short Stature Diagnosis and Referral |
| title_full | Short Stature Diagnosis and Referral |
| title_fullStr | Short Stature Diagnosis and Referral |
| title_full_unstemmed | Short Stature Diagnosis and Referral |
| title_short | Short Stature Diagnosis and Referral |
| title_sort | short stature diagnosis and referral |
| topic | growth hormone short stature diagnosis referral patient management |
| url | http://journal.frontiersin.org/article/10.3389/fendo.2017.00374/full |
| work_keys_str_mv | AT mohamadmaghnie shortstaturediagnosisandreferral AT joseilabarta shortstaturediagnosisandreferral AT ekaterinakoledova shortstaturediagnosisandreferral AT tilmanrrohrer shortstaturediagnosisandreferral |