Collagen type V alpha 2 promotes the development of gastric cancer via M2 macrophage polarization
Gastric cancer is a type of digestive tract cancer with a high morbidity and mortality, which leads to a major health burden worldwide. More research into the functions of the immune system will improve therapy and survival in gastric cancer patients. We attempted to identify potential biomarkers or...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | Chinese Journal of Physiology |
| Subjects: | |
| Online Access: | http://www.cjphysiology.org/article.asp?issn=0304-4920;year=2023;volume=66;issue=2;spage=93;epage=102;aulast=Guo |
| _version_ | 1797824415101091840 |
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| author | Xin Guo Xiaoqian Bu Li Yuan Lina Ji |
| author_facet | Xin Guo Xiaoqian Bu Li Yuan Lina Ji |
| author_sort | Xin Guo |
| collection | DOAJ |
| description | Gastric cancer is a type of digestive tract cancer with a high morbidity and mortality, which leads to a major health burden worldwide. More research into the functions of the immune system will improve therapy and survival in gastric cancer patients. We attempted to identify potential biomarkers or targets in gastric cancer via bioinformatical analysis approaches. Three gene expression profile datasets (GSE79973, GSE103236, and GSE118916) of gastric tissue samples were obtained from the Gene Expression Omnibus database. There were 65 overlapping differentially expressed genes (DEGs) identified from three microarrays. Gene ontology and Kyoto Encyclopedia of Genes and Genomes pathway were carried out for the key functions and pathways enriched in the DEGs. Then, ten hub genes were identified by protein–protein interaction network. In addition, we observed that collagen type V alpha 2 (COL5A2) was linked to gastric cancer prognosis as well as M2 macrophage infiltration. Furthermore, COL5A2 enhanced gastric cancer cell proliferation through the PI3K-AKT signaling pathway and polarized M2 macrophage cells. Therefore, in this study, we found that COL5A2 was associated with the development of gastric cancer which might function as a potential therapeutic target for the disease. |
| first_indexed | 2024-03-13T10:38:38Z |
| format | Article |
| id | doaj.art-031d3497551a46ae902417c07761aae9 |
| institution | Directory Open Access Journal |
| issn | 0304-4920 2666-0059 |
| language | English |
| last_indexed | 2024-03-13T10:38:38Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Chinese Journal of Physiology |
| spelling | doaj.art-031d3497551a46ae902417c07761aae92023-05-18T05:04:32ZengWolters Kluwer Medknow PublicationsChinese Journal of Physiology0304-49202666-00592023-01-016629310210.4103/cjop.CJOP-D-22-00078Collagen type V alpha 2 promotes the development of gastric cancer via M2 macrophage polarizationXin GuoXiaoqian BuLi YuanLina JiGastric cancer is a type of digestive tract cancer with a high morbidity and mortality, which leads to a major health burden worldwide. More research into the functions of the immune system will improve therapy and survival in gastric cancer patients. We attempted to identify potential biomarkers or targets in gastric cancer via bioinformatical analysis approaches. Three gene expression profile datasets (GSE79973, GSE103236, and GSE118916) of gastric tissue samples were obtained from the Gene Expression Omnibus database. There were 65 overlapping differentially expressed genes (DEGs) identified from three microarrays. Gene ontology and Kyoto Encyclopedia of Genes and Genomes pathway were carried out for the key functions and pathways enriched in the DEGs. Then, ten hub genes were identified by protein–protein interaction network. In addition, we observed that collagen type V alpha 2 (COL5A2) was linked to gastric cancer prognosis as well as M2 macrophage infiltration. Furthermore, COL5A2 enhanced gastric cancer cell proliferation through the PI3K-AKT signaling pathway and polarized M2 macrophage cells. Therefore, in this study, we found that COL5A2 was associated with the development of gastric cancer which might function as a potential therapeutic target for the disease.http://www.cjphysiology.org/article.asp?issn=0304-4920;year=2023;volume=66;issue=2;spage=93;epage=102;aulast=Guobioinformatic analysiscell differentiationcollagen type v alpha 2gastric cancerm2 macrophage |
| spellingShingle | Xin Guo Xiaoqian Bu Li Yuan Lina Ji Collagen type V alpha 2 promotes the development of gastric cancer via M2 macrophage polarization Chinese Journal of Physiology bioinformatic analysis cell differentiation collagen type v alpha 2 gastric cancer m2 macrophage |
| title | Collagen type V alpha 2 promotes the development of gastric cancer via M2 macrophage polarization |
| title_full | Collagen type V alpha 2 promotes the development of gastric cancer via M2 macrophage polarization |
| title_fullStr | Collagen type V alpha 2 promotes the development of gastric cancer via M2 macrophage polarization |
| title_full_unstemmed | Collagen type V alpha 2 promotes the development of gastric cancer via M2 macrophage polarization |
| title_short | Collagen type V alpha 2 promotes the development of gastric cancer via M2 macrophage polarization |
| title_sort | collagen type v alpha 2 promotes the development of gastric cancer via m2 macrophage polarization |
| topic | bioinformatic analysis cell differentiation collagen type v alpha 2 gastric cancer m2 macrophage |
| url | http://www.cjphysiology.org/article.asp?issn=0304-4920;year=2023;volume=66;issue=2;spage=93;epage=102;aulast=Guo |
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