Correlation between serum GDF-15 level and pulmonary vascular morphological changes and prognosis in patients with pulmonary arterial hypertension
ObjectiveTo investigate how serum GDF-15 concentration affects pulmonary artery hemodynamics and pulmonary vascular morphological changes in patients with pulmonary arterial hypertension.MethodsA total of 45 patients admitted to our hospital from December 2017 to December 2019, were selected for the...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-05-01
|
| Series: | Frontiers in Cardiovascular Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2023.1085122/full |
| _version_ | 1797822030185234432 |
|---|---|
| author | Yasenjiang Maimaiti Hui Cheng Zitong Guo Xiaolin Yu Adilijiang Tuohuti Guoqing Li |
| author_facet | Yasenjiang Maimaiti Hui Cheng Zitong Guo Xiaolin Yu Adilijiang Tuohuti Guoqing Li |
| author_sort | Yasenjiang Maimaiti |
| collection | DOAJ |
| description | ObjectiveTo investigate how serum GDF-15 concentration affects pulmonary artery hemodynamics and pulmonary vascular morphological changes in patients with pulmonary arterial hypertension.MethodsA total of 45 patients admitted to our hospital from December 2017 to December 2019, were selected for the study. Pulmonary vascular hemodynamics and pulmonary vascular morphology were detected by RHC and IVUS. Serum GDF-15 levels were detected by enzyme-linked immunosorbent assay (ELISA). Based on the concentration of GDF-15, the patients were divided into two groups—the normal GDF-15 group (GDF-15 <1,200 pg/ml, 12 cases) and the elevated GDF-15 group (GDF-15 ≥1,200 pg/ml, 33 cases). A statistical analysis was performed to compare the effects of normal blood GDF-15 levels and high serum GDF-15 levels on hemodynamics and pulmonary vascular morphology in each group of patients.ResultsThe average levels of RVP, sPAP, dPAP, mPAP, and PVR in patients with elevated GDF-15 levels were higher than those in patients with normal GDF-15 levels. The difference between the two groups was statistically significant (P < 0.05). The average levels of Vd, elastic modulus, stiffness index β, lesion length, and PAV in the normal GDF-15 group were lower than those in the elevated GDF-15 group. The average levels of compliance, distensibility, and minimum l umen area were higher than those in the elevated GDF-15 group. The difference between the two groups was statistically significant (P < 0.05). The survival analysis results showed that the 1-year survival rate of patients with normal GDF-15 levels and elevated GDF-15 levels was 100% and 87.9%, respectively, and that the 3-year survival rate of patients with normal GDF-15 levels and elevated GDF-15 levels was 91.7% and 78.8%, respectively. The survival rates of the two groups were compared by the Kaplan Meier method, and the difference was not statistically significant (P > 0.05).ConclusionPatients with pulmonary arterial hypertension with elevated GDF-15 levels have higher pulmonary arterial pressure, higher pulmonary vascular resistance, and more serious pulmonary vascular lesions, which are potentially more harmful. There was no statistically significant difference in survival rates among patients with different serum GDF-15 levels. |
| first_indexed | 2024-03-13T10:01:49Z |
| format | Article |
| id | doaj.art-031da7175cff4abea34401a5cc6000bd |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-03-13T10:01:49Z |
| publishDate | 2023-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-031da7175cff4abea34401a5cc6000bd2023-05-23T04:45:39ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2023-05-011010.3389/fcvm.2023.10851221085122Correlation between serum GDF-15 level and pulmonary vascular morphological changes and prognosis in patients with pulmonary arterial hypertensionYasenjiang Maimaiti0Hui Cheng1Zitong Guo2Xiaolin Yu3Adilijiang Tuohuti4Guoqing Li5Gerontology Center, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, ChinaDepartment of Cardiology, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, ChinaDepartment of Cardiology, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, ChinaDepartment of Cardiology, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, ChinaDepartment of Cardiology, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, ChinaDepartment of Cardiology, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, ChinaObjectiveTo investigate how serum GDF-15 concentration affects pulmonary artery hemodynamics and pulmonary vascular morphological changes in patients with pulmonary arterial hypertension.MethodsA total of 45 patients admitted to our hospital from December 2017 to December 2019, were selected for the study. Pulmonary vascular hemodynamics and pulmonary vascular morphology were detected by RHC and IVUS. Serum GDF-15 levels were detected by enzyme-linked immunosorbent assay (ELISA). Based on the concentration of GDF-15, the patients were divided into two groups—the normal GDF-15 group (GDF-15 <1,200 pg/ml, 12 cases) and the elevated GDF-15 group (GDF-15 ≥1,200 pg/ml, 33 cases). A statistical analysis was performed to compare the effects of normal blood GDF-15 levels and high serum GDF-15 levels on hemodynamics and pulmonary vascular morphology in each group of patients.ResultsThe average levels of RVP, sPAP, dPAP, mPAP, and PVR in patients with elevated GDF-15 levels were higher than those in patients with normal GDF-15 levels. The difference between the two groups was statistically significant (P < 0.05). The average levels of Vd, elastic modulus, stiffness index β, lesion length, and PAV in the normal GDF-15 group were lower than those in the elevated GDF-15 group. The average levels of compliance, distensibility, and minimum l umen area were higher than those in the elevated GDF-15 group. The difference between the two groups was statistically significant (P < 0.05). The survival analysis results showed that the 1-year survival rate of patients with normal GDF-15 levels and elevated GDF-15 levels was 100% and 87.9%, respectively, and that the 3-year survival rate of patients with normal GDF-15 levels and elevated GDF-15 levels was 91.7% and 78.8%, respectively. The survival rates of the two groups were compared by the Kaplan Meier method, and the difference was not statistically significant (P > 0.05).ConclusionPatients with pulmonary arterial hypertension with elevated GDF-15 levels have higher pulmonary arterial pressure, higher pulmonary vascular resistance, and more serious pulmonary vascular lesions, which are potentially more harmful. There was no statistically significant difference in survival rates among patients with different serum GDF-15 levels.https://www.frontiersin.org/articles/10.3389/fcvm.2023.1085122/fullintravascular ultrasoundgrowth differentiation factor-15 (GDF-15)mortality ratepulmonary hypertensionpulmonary vascular morphology |
| spellingShingle | Yasenjiang Maimaiti Hui Cheng Zitong Guo Xiaolin Yu Adilijiang Tuohuti Guoqing Li Correlation between serum GDF-15 level and pulmonary vascular morphological changes and prognosis in patients with pulmonary arterial hypertension Frontiers in Cardiovascular Medicine intravascular ultrasound growth differentiation factor-15 (GDF-15) mortality rate pulmonary hypertension pulmonary vascular morphology |
| title | Correlation between serum GDF-15 level and pulmonary vascular morphological changes and prognosis in patients with pulmonary arterial hypertension |
| title_full | Correlation between serum GDF-15 level and pulmonary vascular morphological changes and prognosis in patients with pulmonary arterial hypertension |
| title_fullStr | Correlation between serum GDF-15 level and pulmonary vascular morphological changes and prognosis in patients with pulmonary arterial hypertension |
| title_full_unstemmed | Correlation between serum GDF-15 level and pulmonary vascular morphological changes and prognosis in patients with pulmonary arterial hypertension |
| title_short | Correlation between serum GDF-15 level and pulmonary vascular morphological changes and prognosis in patients with pulmonary arterial hypertension |
| title_sort | correlation between serum gdf 15 level and pulmonary vascular morphological changes and prognosis in patients with pulmonary arterial hypertension |
| topic | intravascular ultrasound growth differentiation factor-15 (GDF-15) mortality rate pulmonary hypertension pulmonary vascular morphology |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2023.1085122/full |
| work_keys_str_mv | AT yasenjiangmaimaiti correlationbetweenserumgdf15levelandpulmonaryvascularmorphologicalchangesandprognosisinpatientswithpulmonaryarterialhypertension AT huicheng correlationbetweenserumgdf15levelandpulmonaryvascularmorphologicalchangesandprognosisinpatientswithpulmonaryarterialhypertension AT zitongguo correlationbetweenserumgdf15levelandpulmonaryvascularmorphologicalchangesandprognosisinpatientswithpulmonaryarterialhypertension AT xiaolinyu correlationbetweenserumgdf15levelandpulmonaryvascularmorphologicalchangesandprognosisinpatientswithpulmonaryarterialhypertension AT adilijiangtuohuti correlationbetweenserumgdf15levelandpulmonaryvascularmorphologicalchangesandprognosisinpatientswithpulmonaryarterialhypertension AT guoqingli correlationbetweenserumgdf15levelandpulmonaryvascularmorphologicalchangesandprognosisinpatientswithpulmonaryarterialhypertension |