The effects of meloxicam, lornoxicam, ketoprofen, and dexketoprofen on human cervical, colorectal, and mammary carcinoma cell lines
Targeting the inflammation-related molecules with nonsteroidal anti-inflammatory drugs (NSAIDs) represents a promising approach for cancer prevention/therapy. We evaluated the in vitro anticancer effects of meloxicam, lornoxicam, ketoprofen, and dexketoprofen on the proliferation, migration, and apo...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Pensoft Publishers
2024-02-01
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| Series: | Pharmacia |
| Online Access: | https://pharmacia.pensoft.net/article/113677/download/pdf/ |
| _version_ | 1797285306132594688 |
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| author | Lyubomir Marinov Ani Georgieva Reneta Toshkova Ivanka Kostadinova Iliya Mangarov Tanya Toshkova-Yotova Irina Nikolova |
| author_facet | Lyubomir Marinov Ani Georgieva Reneta Toshkova Ivanka Kostadinova Iliya Mangarov Tanya Toshkova-Yotova Irina Nikolova |
| author_sort | Lyubomir Marinov |
| collection | DOAJ |
| description | Targeting the inflammation-related molecules with nonsteroidal anti-inflammatory drugs (NSAIDs) represents a promising approach for cancer prevention/therapy. We evaluated the in vitro anticancer effects of meloxicam, lornoxicam, ketoprofen, and dexketoprofen on the proliferation, migration, and apoptosis of human cervical, colorectal, and mammary carcinoma cells. The antiproliferative activity and cytotoxicity of tested NSAIDs on HeLa, HT-29, and MCF-7 cell lines were assessed by the MTT test. The apoptosis-inducing potential was analyzed by fluorescent staining with acridine orange/ethidium bromide and DAPI. Migration activity was assessed by a wound-healing scratch assay. The tested NSAIDs reduced the viability of the used tumor cell lines. The cytomorphological analysis revealed reduced cell density and mitotic activity and the presence of cells with morphological features of early and late apoptosis. Significant inhibition of the migration capacity was established as well. In conclusion, NSAIDs could be candidates for the development of new pharmacological strategies for the treatment and prevention of cancer. |
| first_indexed | 2024-03-07T18:01:15Z |
| format | Article |
| id | doaj.art-031e233fa8a14b0c94e4b8b0a80f6602 |
| institution | Directory Open Access Journal |
| issn | 2603-557X |
| language | English |
| last_indexed | 2024-03-07T18:01:15Z |
| publishDate | 2024-02-01 |
| publisher | Pensoft Publishers |
| record_format | Article |
| series | Pharmacia |
| spelling | doaj.art-031e233fa8a14b0c94e4b8b0a80f66022024-03-02T10:41:04ZengPensoft PublishersPharmacia2603-557X2024-02-017111210.3897/pharmacia.71.e113677113677The effects of meloxicam, lornoxicam, ketoprofen, and dexketoprofen on human cervical, colorectal, and mammary carcinoma cell linesLyubomir Marinov0Ani Georgieva1Reneta Toshkova2Ivanka Kostadinova3Iliya Mangarov4Tanya Toshkova-Yotova5Irina Nikolova6Medical University of SofiaInstitute of Experimental Morphology, Pathology and Parasitology with Museum, Bulgarian Academy of SciencesInstitute of Experimental Morphology, Pathology and Parasitology with Museum, Bulgarian Academy of SciencesMedical University of SofiaMedical University of SofiaInstitute of Plant Physiology and Genetics, Bulgarian Academy of SciencesMedical University of SofiaTargeting the inflammation-related molecules with nonsteroidal anti-inflammatory drugs (NSAIDs) represents a promising approach for cancer prevention/therapy. We evaluated the in vitro anticancer effects of meloxicam, lornoxicam, ketoprofen, and dexketoprofen on the proliferation, migration, and apoptosis of human cervical, colorectal, and mammary carcinoma cells. The antiproliferative activity and cytotoxicity of tested NSAIDs on HeLa, HT-29, and MCF-7 cell lines were assessed by the MTT test. The apoptosis-inducing potential was analyzed by fluorescent staining with acridine orange/ethidium bromide and DAPI. Migration activity was assessed by a wound-healing scratch assay. The tested NSAIDs reduced the viability of the used tumor cell lines. The cytomorphological analysis revealed reduced cell density and mitotic activity and the presence of cells with morphological features of early and late apoptosis. Significant inhibition of the migration capacity was established as well. In conclusion, NSAIDs could be candidates for the development of new pharmacological strategies for the treatment and prevention of cancer.https://pharmacia.pensoft.net/article/113677/download/pdf/ |
| spellingShingle | Lyubomir Marinov Ani Georgieva Reneta Toshkova Ivanka Kostadinova Iliya Mangarov Tanya Toshkova-Yotova Irina Nikolova The effects of meloxicam, lornoxicam, ketoprofen, and dexketoprofen on human cervical, colorectal, and mammary carcinoma cell lines Pharmacia |
| title | The effects of meloxicam, lornoxicam, ketoprofen, and dexketoprofen on human cervical, colorectal, and mammary carcinoma cell lines |
| title_full | The effects of meloxicam, lornoxicam, ketoprofen, and dexketoprofen on human cervical, colorectal, and mammary carcinoma cell lines |
| title_fullStr | The effects of meloxicam, lornoxicam, ketoprofen, and dexketoprofen on human cervical, colorectal, and mammary carcinoma cell lines |
| title_full_unstemmed | The effects of meloxicam, lornoxicam, ketoprofen, and dexketoprofen on human cervical, colorectal, and mammary carcinoma cell lines |
| title_short | The effects of meloxicam, lornoxicam, ketoprofen, and dexketoprofen on human cervical, colorectal, and mammary carcinoma cell lines |
| title_sort | effects of meloxicam lornoxicam ketoprofen and dexketoprofen on human cervical colorectal and mammary carcinoma cell lines |
| url | https://pharmacia.pensoft.net/article/113677/download/pdf/ |
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