Lysine-glucose Maillard reaction products promote longevity and stress tolerance in Caenorhabditis elegans via the insulin/IGF-1 signaling pathway
The Maillard reaction is associated with the development of distinct flavors and colors during food processing and cooking. This reaction generates numerous chemical compounds, including antioxidants. Caenorhabditis elegans is a model organism for studying aging; its lifespan is prolonged by antioxi...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-12-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464621003996 |
| _version_ | 1818700835589193728 |
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| author | Issei Yokoyama Ou Setoyama Ayumi Urakawa Momo Sugawara Yaqi Jia Yusuke Komiya Jun Nagasao Keizo Arihara |
| author_facet | Issei Yokoyama Ou Setoyama Ayumi Urakawa Momo Sugawara Yaqi Jia Yusuke Komiya Jun Nagasao Keizo Arihara |
| author_sort | Issei Yokoyama |
| collection | DOAJ |
| description | The Maillard reaction is associated with the development of distinct flavors and colors during food processing and cooking. This reaction generates numerous chemical compounds, including antioxidants. Caenorhabditis elegans is a model organism for studying aging; its lifespan is prolonged by antioxidants. In this study, we investigated the effects of lysine-glucose Maillard reaction products (LG MRPs) on C. elegans lifespan. Our results showed that LG MRPs prolonged the lifespan in a dose-dependent (0.001–0.1 M) and improved the reduction of age-related movements. Reactive oxygen species and fat accumulation were decreased upon treatment with LG MRPs. LG MRPs treatment also improved oxidative and heat stress tolerance. Furthermore, mRNA expression of daf-16 which relates to the longevity and its target genes (sod-3, ctl-1, hsp-12.6, and hsp-16.2) was increased. These results suggest that LG MRPs might contribute to longevity via the insulin/insulin-like growth factor signaling pathway in C. elegans. |
| first_indexed | 2024-12-17T15:11:16Z |
| format | Article |
| id | doaj.art-031f335e725c409cae9b932a00e2625f |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-17T15:11:16Z |
| publishDate | 2021-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-031f335e725c409cae9b932a00e2625f2022-12-21T21:43:40ZengElsevierJournal of Functional Foods1756-46462021-12-0187104750Lysine-glucose Maillard reaction products promote longevity and stress tolerance in Caenorhabditis elegans via the insulin/IGF-1 signaling pathwayIssei Yokoyama0Ou Setoyama1Ayumi Urakawa2Momo Sugawara3Yaqi Jia4Yusuke Komiya5Jun Nagasao6Keizo Arihara7School of Veterinary Medicine, Kitasato University, Japan; Corresponding author at: Department of Animal Science, School of Veterinary Medicine, Kitasato University, Towada 034-8628, Japan.Kanagawa Institute of Industrial Science and Technology, JapanSchool of Veterinary Medicine, Kitasato University, JapanSchool of Veterinary Medicine, Kitasato University, JapanSchool of Veterinary Medicine, Kitasato University, JapanSchool of Veterinary Medicine, Kitasato University, JapanSchool of Veterinary Medicine, Kitasato University, JapanSchool of Veterinary Medicine, Kitasato University, JapanThe Maillard reaction is associated with the development of distinct flavors and colors during food processing and cooking. This reaction generates numerous chemical compounds, including antioxidants. Caenorhabditis elegans is a model organism for studying aging; its lifespan is prolonged by antioxidants. In this study, we investigated the effects of lysine-glucose Maillard reaction products (LG MRPs) on C. elegans lifespan. Our results showed that LG MRPs prolonged the lifespan in a dose-dependent (0.001–0.1 M) and improved the reduction of age-related movements. Reactive oxygen species and fat accumulation were decreased upon treatment with LG MRPs. LG MRPs treatment also improved oxidative and heat stress tolerance. Furthermore, mRNA expression of daf-16 which relates to the longevity and its target genes (sod-3, ctl-1, hsp-12.6, and hsp-16.2) was increased. These results suggest that LG MRPs might contribute to longevity via the insulin/insulin-like growth factor signaling pathway in C. elegans.http://www.sciencedirect.com/science/article/pii/S1756464621003996Maillard reactionMaillard reaction productsAntioxidant propertiesAnti-agingStress toleranceCaenorhabditis elegans |
| spellingShingle | Issei Yokoyama Ou Setoyama Ayumi Urakawa Momo Sugawara Yaqi Jia Yusuke Komiya Jun Nagasao Keizo Arihara Lysine-glucose Maillard reaction products promote longevity and stress tolerance in Caenorhabditis elegans via the insulin/IGF-1 signaling pathway Journal of Functional Foods Maillard reaction Maillard reaction products Antioxidant properties Anti-aging Stress tolerance Caenorhabditis elegans |
| title | Lysine-glucose Maillard reaction products promote longevity and stress tolerance in Caenorhabditis elegans via the insulin/IGF-1 signaling pathway |
| title_full | Lysine-glucose Maillard reaction products promote longevity and stress tolerance in Caenorhabditis elegans via the insulin/IGF-1 signaling pathway |
| title_fullStr | Lysine-glucose Maillard reaction products promote longevity and stress tolerance in Caenorhabditis elegans via the insulin/IGF-1 signaling pathway |
| title_full_unstemmed | Lysine-glucose Maillard reaction products promote longevity and stress tolerance in Caenorhabditis elegans via the insulin/IGF-1 signaling pathway |
| title_short | Lysine-glucose Maillard reaction products promote longevity and stress tolerance in Caenorhabditis elegans via the insulin/IGF-1 signaling pathway |
| title_sort | lysine glucose maillard reaction products promote longevity and stress tolerance in caenorhabditis elegans via the insulin igf 1 signaling pathway |
| topic | Maillard reaction Maillard reaction products Antioxidant properties Anti-aging Stress tolerance Caenorhabditis elegans |
| url | http://www.sciencedirect.com/science/article/pii/S1756464621003996 |
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