Evaluation of a Dedicated Software “Elements™ Spine SRS, Brainlab®” for Target Volume Definition in the Treatment of Spinal Bone Metastases With Stereotactic Body Radiotherapy
IntroductionStereotactic body radiotherapy (SBRT) is a treatment option for spine metastases. The International Spine Radiosurgery Consortium (ISRC) has published consensus guidelines for target delineation in spine SBRT. A new software called Elements™ Spine SRS by Brainlab® that includes the modul...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-05-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.827195/full |
| _version_ | 1811306474055401472 |
|---|---|
| author | Maximilien Rogé Ahmed Hadj Henni Yasmine Adda Neggaz Romain Mallet Chantal Hanzen Bernard Dubray Bernard Dubray Elyse Colard David Gensanne David Gensanne Sébastien Thureau Sébastien Thureau |
| author_facet | Maximilien Rogé Ahmed Hadj Henni Yasmine Adda Neggaz Romain Mallet Chantal Hanzen Bernard Dubray Bernard Dubray Elyse Colard David Gensanne David Gensanne Sébastien Thureau Sébastien Thureau |
| author_sort | Maximilien Rogé |
| collection | DOAJ |
| description | IntroductionStereotactic body radiotherapy (SBRT) is a treatment option for spine metastases. The International Spine Radiosurgery Consortium (ISRC) has published consensus guidelines for target delineation in spine SBRT. A new software called Elements™ Spine SRS by Brainlab® that includes the module Elements SmartBrush Spine (v3.0, Munich, Germany) has been developed specifically for SBRT treatment of spine metastases, and the latter provides the ability to perform semiautomatic clinical target volume (CTV) generation based on gross tumor volume (GTV) localization and guidelines. The aims of our study were to evaluate this software by studying differences in volumes between semiautomatic CTV contours compared to manual contouring performed by an expert radiation oncologist and to determine the dosimetric impact of these differences on treatment plans.MethodsA total of 35 volumes (“Expert GTV” and “Expert CTV”) from 30 patients were defined by a single expert. A semiautomatic definition of these 35 CTVs based on the location of “Expert GTV” and following ISRC guidelines was also performed in Elements SmartBrush Spine (“Brainlab CTV”). The spatial overlap between “Brainlab” and “Expert” CTVs was calculated using the Dice similarity coefficient (DSC). We considered a threshold of 0.80 or above to indicate that Elements SmartBrush Spine performed very well with adequate contours for clinical use. Two dosimetric treatment plans, each corresponding to a specific planning target volume (PTV; Expert PTV, Brainlab PTV), were created for 11 patients.ResultsWe showed that “Brainlab CTV” and “Expert CTV” mean volumes were 29.8 ± 16.1 and 28.7 ± 15.7 cm3, respectively (p = 0.23). We also showed that the mean DSC for semiautomatic contouring relative to expert manual contouring was 0.85 ± 0.08 and less than 0.80 in five cases. For metastases involving the vertebral body only (n = 13,37%), the mean DSC was 0.90 ± 0.03, and for ones involving other or several vertebral regions (n = 22.63%), the mean DSC was 0.81 ± 0.08 (p < 0.001). The comparison of dosimetric treatment plans was performed for equivalent PTV coverage. There were no differences between doses received by organs at risk (spinal cord and esophagus) for Expert and Brainlab PTVs, respectively.ConclusionThe results showed that the semiautomatic method had quite good accuracy and can be used in clinical routine even for complex lesions. |
| first_indexed | 2024-04-13T08:46:11Z |
| format | Article |
| id | doaj.art-031fec2f5dfa47b3bf7ae61351527131 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-13T08:46:11Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-031fec2f5dfa47b3bf7ae613515271312022-12-22T02:53:39ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-05-011210.3389/fonc.2022.827195827195Evaluation of a Dedicated Software “Elements™ Spine SRS, Brainlab®” for Target Volume Definition in the Treatment of Spinal Bone Metastases With Stereotactic Body RadiotherapyMaximilien Rogé0Ahmed Hadj Henni1Yasmine Adda Neggaz2Romain Mallet3Chantal Hanzen4Bernard Dubray5Bernard Dubray6Elyse Colard7David Gensanne8David Gensanne9Sébastien Thureau10Sébastien Thureau11Départment of Radiation Oncology, Centre Henri Becquerel, Rouen, FranceDépartment of Radiation Oncology, Centre Henri Becquerel, Rouen, FranceDépartment of Radiation Oncology, Centre Henri Becquerel, Rouen, FranceDépartment of Radiation Oncology, Centre Henri Becquerel, Rouen, FranceDépartment of Radiation Oncology, Centre Henri Becquerel, Rouen, FranceDépartment of Radiation Oncology, Centre Henri Becquerel, Rouen, FranceQuantIF-LITIS EA4108, University of Rouen, Rouen, FranceDépartment of Radiation Oncology, Centre Henri Becquerel, Rouen, FranceDépartment of Radiation Oncology, Centre Henri Becquerel, Rouen, FranceQuantIF-LITIS EA4108, University of Rouen, Rouen, FranceDépartment of Radiation Oncology, Centre Henri Becquerel, Rouen, FranceQuantIF-LITIS EA4108, University of Rouen, Rouen, FranceIntroductionStereotactic body radiotherapy (SBRT) is a treatment option for spine metastases. The International Spine Radiosurgery Consortium (ISRC) has published consensus guidelines for target delineation in spine SBRT. A new software called Elements™ Spine SRS by Brainlab® that includes the module Elements SmartBrush Spine (v3.0, Munich, Germany) has been developed specifically for SBRT treatment of spine metastases, and the latter provides the ability to perform semiautomatic clinical target volume (CTV) generation based on gross tumor volume (GTV) localization and guidelines. The aims of our study were to evaluate this software by studying differences in volumes between semiautomatic CTV contours compared to manual contouring performed by an expert radiation oncologist and to determine the dosimetric impact of these differences on treatment plans.MethodsA total of 35 volumes (“Expert GTV” and “Expert CTV”) from 30 patients were defined by a single expert. A semiautomatic definition of these 35 CTVs based on the location of “Expert GTV” and following ISRC guidelines was also performed in Elements SmartBrush Spine (“Brainlab CTV”). The spatial overlap between “Brainlab” and “Expert” CTVs was calculated using the Dice similarity coefficient (DSC). We considered a threshold of 0.80 or above to indicate that Elements SmartBrush Spine performed very well with adequate contours for clinical use. Two dosimetric treatment plans, each corresponding to a specific planning target volume (PTV; Expert PTV, Brainlab PTV), were created for 11 patients.ResultsWe showed that “Brainlab CTV” and “Expert CTV” mean volumes were 29.8 ± 16.1 and 28.7 ± 15.7 cm3, respectively (p = 0.23). We also showed that the mean DSC for semiautomatic contouring relative to expert manual contouring was 0.85 ± 0.08 and less than 0.80 in five cases. For metastases involving the vertebral body only (n = 13,37%), the mean DSC was 0.90 ± 0.03, and for ones involving other or several vertebral regions (n = 22.63%), the mean DSC was 0.81 ± 0.08 (p < 0.001). The comparison of dosimetric treatment plans was performed for equivalent PTV coverage. There were no differences between doses received by organs at risk (spinal cord and esophagus) for Expert and Brainlab PTVs, respectively.ConclusionThe results showed that the semiautomatic method had quite good accuracy and can be used in clinical routine even for complex lesions.https://www.frontiersin.org/articles/10.3389/fonc.2022.827195/fullstereotactic body radiotherapyclinical target volumespinal metastasessoftwareartificial intelligence (AI) |
| spellingShingle | Maximilien Rogé Ahmed Hadj Henni Yasmine Adda Neggaz Romain Mallet Chantal Hanzen Bernard Dubray Bernard Dubray Elyse Colard David Gensanne David Gensanne Sébastien Thureau Sébastien Thureau Evaluation of a Dedicated Software “Elements™ Spine SRS, Brainlab®” for Target Volume Definition in the Treatment of Spinal Bone Metastases With Stereotactic Body Radiotherapy Frontiers in Oncology stereotactic body radiotherapy clinical target volume spinal metastases software artificial intelligence (AI) |
| title | Evaluation of a Dedicated Software “Elements™ Spine SRS, Brainlab®” for Target Volume Definition in the Treatment of Spinal Bone Metastases With Stereotactic Body Radiotherapy |
| title_full | Evaluation of a Dedicated Software “Elements™ Spine SRS, Brainlab®” for Target Volume Definition in the Treatment of Spinal Bone Metastases With Stereotactic Body Radiotherapy |
| title_fullStr | Evaluation of a Dedicated Software “Elements™ Spine SRS, Brainlab®” for Target Volume Definition in the Treatment of Spinal Bone Metastases With Stereotactic Body Radiotherapy |
| title_full_unstemmed | Evaluation of a Dedicated Software “Elements™ Spine SRS, Brainlab®” for Target Volume Definition in the Treatment of Spinal Bone Metastases With Stereotactic Body Radiotherapy |
| title_short | Evaluation of a Dedicated Software “Elements™ Spine SRS, Brainlab®” for Target Volume Definition in the Treatment of Spinal Bone Metastases With Stereotactic Body Radiotherapy |
| title_sort | evaluation of a dedicated software elements™ spine srs brainlab r for target volume definition in the treatment of spinal bone metastases with stereotactic body radiotherapy |
| topic | stereotactic body radiotherapy clinical target volume spinal metastases software artificial intelligence (AI) |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.827195/full |
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