The Study of Methylene Blue Loading into Chitosan-graft-Maleic Sponges
This work succeeded in synthesizing sponges from chitosan-graft-maleic anhydride. Chitosan and maleic anhydride at a certain mass ratio (1:2, 1:1; and 2:1) were reacted in dimethyl sulfoxide (DMSO) at 60? for 24 hours. While the gel formation was carried out in distilled water using a dialysis t...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Universitas Indonesia
2022-12-01
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| Series: | International Journal of Technology |
| Subjects: | |
| Online Access: | https://ijtech.eng.ui.ac.id/article/view/6133 |
| _version_ | 1797974741544337408 |
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| author | Daniel Timotius Yuni Kusumastuti Rozita Omar Razif Harun Siti Mazlina Mustapa Kamal Siti Nurul Aisyiyah Jenie Himawan Tri Bayu Murti Petrus |
| author_facet | Daniel Timotius Yuni Kusumastuti Rozita Omar Razif Harun Siti Mazlina Mustapa Kamal Siti Nurul Aisyiyah Jenie Himawan Tri Bayu Murti Petrus |
| author_sort | Daniel Timotius |
| collection | DOAJ |
| description | This work succeeded in synthesizing sponges
from chitosan-graft-maleic anhydride. Chitosan and maleic anhydride at a
certain mass ratio (1:2, 1:1; and 2:1) were reacted in dimethyl sulfoxide
(DMSO) at 60? for 24 hours. While the gel formation was carried out in distilled
water using a dialysis tube. The removal of DMSO from the gel was carried out
by soaking the gel in distilled water for two days. After that, the obtained
gel was frozen at -25oC overnight before being lyophilized under a
vacuum at -40oC for 24 hours. The dry sponge weight obtained after lyophilization is
about 5.61% – 6.77% (dry sponge/wet gel). FTIR and TG/DTA then characterized
the sponges. The intensity of the new strong FTIR band appeared in the
chitosan-graft-maleic sponge at 1560.13 cm-1, which corresponds to
the C=C strain. The results of TG/DTA showed that pure chitosan and sponge
chitosan-maleate underwent two stages of degradation, namely evaporation of
water and pyrolysis of organic compounds. The shift in the peak rate of
degradation in the second stage occurred at 300? for pure chitosan and at 340? for a
graft-chitosan-maleate sponge. Both results indicate that the reaction was
successful. The drug loading capability was investigated using methylene blue
as the drug model. The drug loading kinetics corresponded to a
pseudo-first-order model with kf ranging from 0.287 to 0.317 day-1.
According to the Freundlich model, the adsorption equilibrium with Kf
and 1/n values was 4.923 mg/gram and 2.192, respectively. |
| first_indexed | 2024-04-11T04:23:25Z |
| format | Article |
| id | doaj.art-03208275392640aab34d0a5ade34c310 |
| institution | Directory Open Access Journal |
| issn | 2086-9614 2087-2100 |
| language | English |
| last_indexed | 2024-04-11T04:23:25Z |
| publishDate | 2022-12-01 |
| publisher | Universitas Indonesia |
| record_format | Article |
| series | International Journal of Technology |
| spelling | doaj.art-03208275392640aab34d0a5ade34c3102022-12-30T02:23:44ZengUniversitas IndonesiaInternational Journal of Technology2086-96142087-21002022-12-011381796180510.14716/ijtech.v13i8.61336133The Study of Methylene Blue Loading into Chitosan-graft-Maleic SpongesDaniel Timotius0Yuni Kusumastuti1Rozita Omar2Razif Harun3Siti Mazlina Mustapa Kamal4Siti Nurul Aisyiyah Jenie5Himawan Tri Bayu Murti Petrus6Department of Chemical Engineering, Faculty of Industrial Engineering, Universitas Pembangunan Nasional “Veteran” Yogyakarta, Jl. SWK 104, Yogyakarta 55283, IndonesiaDepartment of Chemical Engineering, Faculty of Engineering, Universitas Gadjah Mada, Jalan Grafika 2, Yogyakarta 55281, IndonesiaDepartment of Chemical and Environmental Engineering, Faculty of Engineering, Universiti Putra Malaysia, Serdang 43400, Selangor, MalaysiaDepartment of Chemical and Environmental Engineering, Faculty of Engineering, Universiti Putra Malaysia, Serdang 43400, Selangor, MalaysiaDepartment of Food and Process Engineering, Faculty of Engineering, Universiti Putra Malaysia, Serdang 43400, Selangor, MalaysiaResearch Centre for Chemistry, National Research and Innovation Agency (BRIN), Kawasan Puspiptek Building 452, Serpong, Tangerang Selatan 15314, IndonesiaDepartment of Chemical Engineering, Faculty of Engineering, Universitas Gadjah Mada, Jalan Grafika 2, Yogyakarta 55281, IndonesiaThis work succeeded in synthesizing sponges from chitosan-graft-maleic anhydride. Chitosan and maleic anhydride at a certain mass ratio (1:2, 1:1; and 2:1) were reacted in dimethyl sulfoxide (DMSO) at 60? for 24 hours. While the gel formation was carried out in distilled water using a dialysis tube. The removal of DMSO from the gel was carried out by soaking the gel in distilled water for two days. After that, the obtained gel was frozen at -25oC overnight before being lyophilized under a vacuum at -40oC for 24 hours. The dry sponge weight obtained after lyophilization is about 5.61% – 6.77% (dry sponge/wet gel). FTIR and TG/DTA then characterized the sponges. The intensity of the new strong FTIR band appeared in the chitosan-graft-maleic sponge at 1560.13 cm-1, which corresponds to the C=C strain. The results of TG/DTA showed that pure chitosan and sponge chitosan-maleate underwent two stages of degradation, namely evaporation of water and pyrolysis of organic compounds. The shift in the peak rate of degradation in the second stage occurred at 300? for pure chitosan and at 340? for a graft-chitosan-maleate sponge. Both results indicate that the reaction was successful. The drug loading capability was investigated using methylene blue as the drug model. The drug loading kinetics corresponded to a pseudo-first-order model with kf ranging from 0.287 to 0.317 day-1. According to the Freundlich model, the adsorption equilibrium with Kf and 1/n values was 4.923 mg/gram and 2.192, respectively.https://ijtech.eng.ui.ac.id/article/view/6133chitosandrug delivery systemmaleic anhydridemethylene bluesponges |
| spellingShingle | Daniel Timotius Yuni Kusumastuti Rozita Omar Razif Harun Siti Mazlina Mustapa Kamal Siti Nurul Aisyiyah Jenie Himawan Tri Bayu Murti Petrus The Study of Methylene Blue Loading into Chitosan-graft-Maleic Sponges International Journal of Technology chitosan drug delivery system maleic anhydride methylene blue sponges |
| title | The Study of Methylene Blue Loading into Chitosan-graft-Maleic Sponges |
| title_full | The Study of Methylene Blue Loading into Chitosan-graft-Maleic Sponges |
| title_fullStr | The Study of Methylene Blue Loading into Chitosan-graft-Maleic Sponges |
| title_full_unstemmed | The Study of Methylene Blue Loading into Chitosan-graft-Maleic Sponges |
| title_short | The Study of Methylene Blue Loading into Chitosan-graft-Maleic Sponges |
| title_sort | study of methylene blue loading into chitosan graft maleic sponges |
| topic | chitosan drug delivery system maleic anhydride methylene blue sponges |
| url | https://ijtech.eng.ui.ac.id/article/view/6133 |
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