Chronic optogenetic induction of stress granules is cytotoxic and reveals the evolution of ALS-FTD pathology

Chronic optogenetic induction of stress granules is cytotoxic and reveals the evolution of ALS-FTD pathology

Stress granules (SGs) are non-membrane-bound RNA-protein granules that assemble through phase separation in response to cellular stress. Disturbances in SG dynamics have been implicated as a primary driver of neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and frontotempora...

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Bibliographic Details
Main Authors: Peipei Zhang, Baochang Fan, Peiguo Yang, Jamshid Temirov, James Messing, Hong Joo Kim, J Paul Taylor
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-03-01
Series:eLife
Subjects:
stress granule
optogranule
ALS
FTD
TDP-43
phase separation
Online Access:https://elifesciences.org/articles/39578

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