Significance of iron reduction for the therapy of chronic hepatitis C
Background. It has been established that many patients with chronic hepatitis C have elevated serum iron, feritin levels and iron deposits in the liver. Therefore, the liver damage due to hepatitis C virus may be aggravated with iron overload. In many studies higher levels of iron in the blood and t...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Military Health Department, Ministry of Defence, Serbia
2005-01-01
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| Series: | Vojnosanitetski Pregled |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2005/0042-84500502161N.pdf |
| _version_ | 1826574872884543488 |
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| author | Nožić Darko Balint Bela Stanković Nebojša Dimitrijević Jovan Nešković Gorana |
| author_facet | Nožić Darko Balint Bela Stanković Nebojša Dimitrijević Jovan Nešković Gorana |
| author_sort | Nožić Darko |
| collection | DOAJ |
| description | Background. It has been established that many patients with chronic hepatitis C have elevated serum iron, feritin levels and iron deposits in the liver. Therefore, the liver damage due to hepatitis C virus may be aggravated with iron overload. In many studies higher levels of iron in the blood and the liver were connected with the decreased response to interferon-alfa therapy for chronic viral hepatitis C. Recent introduction of pegylated interferons plus ribavirin has improved the therapeutic response, so it is now possible to cure more than 50% of the patients. Case report. Three patients with chronic hepatitis C and iron overload were presented. Iron reduction therapy using phlebotomy or eritrocytapheresis with plasmapheresis was done at different times in regard to specific antiviral therapy or as a sole therapy. Conclusion. It has been shown that iron reduction, sole or combined with antiviral therapy, led to the deacreased aminotransferase serum activity and might have slow down the evolution of chronic hepatitis C viral infection. |
| first_indexed | 2024-12-12T20:52:47Z |
| format | Article |
| id | doaj.art-0323f693af8f44ed93cefe48821758d0 |
| institution | Directory Open Access Journal |
| issn | 0042-8450 |
| language | English |
| last_indexed | 2025-03-14T13:05:43Z |
| publishDate | 2005-01-01 |
| publisher | Military Health Department, Ministry of Defence, Serbia |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj.art-0323f693af8f44ed93cefe48821758d02025-03-02T01:14:03ZengMilitary Health Department, Ministry of Defence, SerbiaVojnosanitetski Pregled0042-84502005-01-0162216116410.2298/VSP0502161NSignificance of iron reduction for the therapy of chronic hepatitis CNožić DarkoBalint BelaStanković NebojšaDimitrijević JovanNešković GoranaBackground. It has been established that many patients with chronic hepatitis C have elevated serum iron, feritin levels and iron deposits in the liver. Therefore, the liver damage due to hepatitis C virus may be aggravated with iron overload. In many studies higher levels of iron in the blood and the liver were connected with the decreased response to interferon-alfa therapy for chronic viral hepatitis C. Recent introduction of pegylated interferons plus ribavirin has improved the therapeutic response, so it is now possible to cure more than 50% of the patients. Case report. Three patients with chronic hepatitis C and iron overload were presented. Iron reduction therapy using phlebotomy or eritrocytapheresis with plasmapheresis was done at different times in regard to specific antiviral therapy or as a sole therapy. Conclusion. It has been shown that iron reduction, sole or combined with antiviral therapy, led to the deacreased aminotransferase serum activity and might have slow down the evolution of chronic hepatitis C viral infection.http://www.doiserbia.nb.rs/img/doi/0042-8450/2005/0042-84500502161N.pdfhepatitis Cchronicironinterferonsphlebotomyplasmapheresis |
| spellingShingle | Nožić Darko Balint Bela Stanković Nebojša Dimitrijević Jovan Nešković Gorana Significance of iron reduction for the therapy of chronic hepatitis C Vojnosanitetski Pregled hepatitis C chronic iron interferons phlebotomy plasmapheresis |
| title | Significance of iron reduction for the therapy of chronic hepatitis C |
| title_full | Significance of iron reduction for the therapy of chronic hepatitis C |
| title_fullStr | Significance of iron reduction for the therapy of chronic hepatitis C |
| title_full_unstemmed | Significance of iron reduction for the therapy of chronic hepatitis C |
| title_short | Significance of iron reduction for the therapy of chronic hepatitis C |
| title_sort | significance of iron reduction for the therapy of chronic hepatitis c |
| topic | hepatitis C chronic iron interferons phlebotomy plasmapheresis |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2005/0042-84500502161N.pdf |
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