Tumour microenvironments induce expression of urokinase plasminogen activator receptor (uPAR) and concomitant activation of gelatinolytic enzymes.

Tumour microenvironments induce expression of urokinase plasminogen activator receptor (uPAR) and concomitant activation of gelatinolytic enzymes.

The urokinase plasminogen activator receptor (uPAR) is associated with poor prognosis in oral squamous cell carcinoma (OSCC), and increased expression of uPAR is often found at the invasive tumour front. The aim of the current study was to elucidate the role of uPAR in invasion and metastasis of OSC...

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Main Authors: Synnøve Magnussen, Elin Hadler-Olsen, Nadezhda Latysheva, Emma Pirila, Sonja E Steigen, Robert Hanes, Tuula Salo, Jan-Olof Winberg, Lars Uhlin-Hansen, Gunbjørg Svineng
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4144900?pdf=render

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