Optimization of Dissolution Compartments in a Biorelevant Dissolution Apparatus Golem v2, Supported by Multivariate Analysis
Biorelevant dissolution instruments represent an important tool for pharmaceutical research and development. These instruments are designed to simulate the dissolution of drug formulations in conditions most closely mimicking the gastrointestinal tract. In this work, we focused on the optimization o...
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| Format: | Article |
| Language: | English |
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MDPI AG
2017-11-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/22/12/2042 |
| _version_ | 1819154903881220096 |
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| author | Ivan Stupák Sylvie Pavloková Jakub Vysloužil Jiří Dohnal Martin Čulen |
| author_facet | Ivan Stupák Sylvie Pavloková Jakub Vysloužil Jiří Dohnal Martin Čulen |
| author_sort | Ivan Stupák |
| collection | DOAJ |
| description | Biorelevant dissolution instruments represent an important tool for pharmaceutical research and development. These instruments are designed to simulate the dissolution of drug formulations in conditions most closely mimicking the gastrointestinal tract. In this work, we focused on the optimization of dissolution compartments/vessels for an updated version of the biorelevant dissolution apparatus—Golem v2. We designed eight compartments of uniform size but different inner geometry. The dissolution performance of the compartments was tested using immediate release caffeine tablets and evaluated by standard statistical methods and principal component analysis. Based on two phases of dissolution testing (using 250 and 100 mL of dissolution medium), we selected two compartment types yielding the highest measurement reproducibility. We also confirmed a statistically ssignificant effect of agitation rate and dissolution volume on the extent of drug dissolved and measurement reproducibility. |
| first_indexed | 2024-12-22T15:28:29Z |
| format | Article |
| id | doaj.art-032435f621e844e3b297c763d39d1969 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-22T15:28:29Z |
| publishDate | 2017-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-032435f621e844e3b297c763d39d19692022-12-21T18:21:26ZengMDPI AGMolecules1420-30492017-11-012212204210.3390/molecules22122042molecules22122042Optimization of Dissolution Compartments in a Biorelevant Dissolution Apparatus Golem v2, Supported by Multivariate AnalysisIvan Stupák0Sylvie Pavloková1Jakub Vysloužil2Jiří Dohnal3Martin Čulen4Department of Chemical Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Palackeho 1, 612 42 Brno, Czech RepublicDepartment of Pharmaceutics, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Palackeho 1, 612 42 Brno, Czech RepublicDepartment of Pharmaceutics, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Palackeho 1, 612 42 Brno, Czech RepublicDepartment of Social Pharmacy, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Palackeho 1, 612 42 Brno, Czech RepublicCentral Laboratories, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Palackeho 1, 612 42 Brno, Czech RepublicBiorelevant dissolution instruments represent an important tool for pharmaceutical research and development. These instruments are designed to simulate the dissolution of drug formulations in conditions most closely mimicking the gastrointestinal tract. In this work, we focused on the optimization of dissolution compartments/vessels for an updated version of the biorelevant dissolution apparatus—Golem v2. We designed eight compartments of uniform size but different inner geometry. The dissolution performance of the compartments was tested using immediate release caffeine tablets and evaluated by standard statistical methods and principal component analysis. Based on two phases of dissolution testing (using 250 and 100 mL of dissolution medium), we selected two compartment types yielding the highest measurement reproducibility. We also confirmed a statistically ssignificant effect of agitation rate and dissolution volume on the extent of drug dissolved and measurement reproducibility.https://www.mdpi.com/1420-3049/22/12/2042dissolutionbiorelevantGolemcaffeinemultivariate data analysis |
| spellingShingle | Ivan Stupák Sylvie Pavloková Jakub Vysloužil Jiří Dohnal Martin Čulen Optimization of Dissolution Compartments in a Biorelevant Dissolution Apparatus Golem v2, Supported by Multivariate Analysis Molecules dissolution biorelevant Golem caffeine multivariate data analysis |
| title | Optimization of Dissolution Compartments in a Biorelevant Dissolution Apparatus Golem v2, Supported by Multivariate Analysis |
| title_full | Optimization of Dissolution Compartments in a Biorelevant Dissolution Apparatus Golem v2, Supported by Multivariate Analysis |
| title_fullStr | Optimization of Dissolution Compartments in a Biorelevant Dissolution Apparatus Golem v2, Supported by Multivariate Analysis |
| title_full_unstemmed | Optimization of Dissolution Compartments in a Biorelevant Dissolution Apparatus Golem v2, Supported by Multivariate Analysis |
| title_short | Optimization of Dissolution Compartments in a Biorelevant Dissolution Apparatus Golem v2, Supported by Multivariate Analysis |
| title_sort | optimization of dissolution compartments in a biorelevant dissolution apparatus golem v2 supported by multivariate analysis |
| topic | dissolution biorelevant Golem caffeine multivariate data analysis |
| url | https://www.mdpi.com/1420-3049/22/12/2042 |
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