Early Life Irradiation-Induced Hypoplasia and Impairment of Neurogenesis in the Dentate Gyrus and Adult Depression Are Mediated by MicroRNA- 34a-5p/T-Cell Intracytoplasmic Antigen-1 Pathway

Early Life Irradiation-Induced Hypoplasia and Impairment of Neurogenesis in the Dentate Gyrus and Adult Depression Are Mediated by MicroRNA- 34a-5p/T-Cell Intracytoplasmic Antigen-1 Pathway

Early life radiation exposure causes abnormal brain development, leading to adult depression. However, few studies have been conducted to explore pre- or post-natal irradiation-induced depression-related neuropathological changes. Relevant molecular mechanisms are also poorly understood. We induced...

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Bibliographic Details
Main Authors: Hong Wang, Zhaowu Ma, Hongyuan Shen, Zijun Wu, Lian Liu, Boxu Ren, Peiyan Wong, Gautam Sethi, Fengru Tang
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Cells
Subjects:
γ-irradiation
depression
neurogenesis
miR-34a-5p
tia1
Online Access:https://www.mdpi.com/2073-4409/10/9/2476

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