Methotrexate-induced acute cardiotoxicity requiring veno-arterial extracorporeal membrane oxygenation support: a case report

Methotrexate-induced acute cardiotoxicity requiring veno-arterial extracorporeal membrane oxygenation support: a case report

Abstract Background Methotrexate is an antifolate antimetabolite that inhibits the activity of dihydrofolate reductase by acting as a false substrate, which leads to defects of DNA synthesis, specifically the inhibition of purine and pyrimidine synthesis. Thus, methotrexate is a powerful agent for t...

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Bibliographic Details
Main Authors: Sareena Shah, Kristen Haeger-Overstreet, Brigid Flynn
Format: Article
Language:English
Published: BMC 2022-11-01
Series:Journal of Medical Case Reports
Subjects:
Methotrexate toxicity
Acute cardiotoxicity
Leucovorin rescue
Online Access:https://doi.org/10.1186/s13256-022-03644-9

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