Basophils as Key Regulators of Allergic Inflammation and Th2-type Immunity
Basophils have long been suspected as playing more than a bystander role in initiating and maintaining allergic disorders, despite their relatively low numbers compared with other effector cells, such as mast cells and eosinophils. In vitro studies clearly demonstrated their propensity to generate p...
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| Format: | Article |
| Language: | English |
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Elsevier
2008-01-01
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| Series: | World Allergy Organization Journal |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1939455119305861 |
| _version_ | 1818338145717977088 |
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| author | Bernhard F. Gibbs |
| author_facet | Bernhard F. Gibbs |
| author_sort | Bernhard F. Gibbs |
| collection | DOAJ |
| description | Basophils have long been suspected as playing more than a bystander role in initiating and maintaining allergic disorders, despite their relatively low numbers compared with other effector cells, such as mast cells and eosinophils. In vitro studies clearly demonstrated their propensity to generate proallergic cytokines, such as interleukin 4 and interleukin 13, as well as histamine and leukotrienes after simulation with allergens and innate IgE-dependent triggers. However, only very recently have mouse basophils been identified as key regulators of allergy in vivo, including orchestrating Th2 immunity to protease allergens in the induction phase. This review highlights these exciting advances that go far in unraveling our understanding of basophil function in the orchestration of allergic inflammation. Keywords: basophils, mast cells, Th2 immunity, allergy |
| first_indexed | 2024-12-13T15:06:28Z |
| format | Article |
| id | doaj.art-03261a16356e46b7a36ddc11fcb79b0c |
| institution | Directory Open Access Journal |
| issn | 1939-4551 |
| language | English |
| last_indexed | 2024-12-13T15:06:28Z |
| publishDate | 2008-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | World Allergy Organization Journal |
| spelling | doaj.art-03261a16356e46b7a36ddc11fcb79b0c2022-12-21T23:40:59ZengElsevierWorld Allergy Organization Journal1939-45512008-01-0117123128Basophils as Key Regulators of Allergic Inflammation and Th2-type ImmunityBernhard F. Gibbs0Reprints:; Medway School of Pharmacy, University of Kent, Kent, United KingdomBasophils have long been suspected as playing more than a bystander role in initiating and maintaining allergic disorders, despite their relatively low numbers compared with other effector cells, such as mast cells and eosinophils. In vitro studies clearly demonstrated their propensity to generate proallergic cytokines, such as interleukin 4 and interleukin 13, as well as histamine and leukotrienes after simulation with allergens and innate IgE-dependent triggers. However, only very recently have mouse basophils been identified as key regulators of allergy in vivo, including orchestrating Th2 immunity to protease allergens in the induction phase. This review highlights these exciting advances that go far in unraveling our understanding of basophil function in the orchestration of allergic inflammation. Keywords: basophils, mast cells, Th2 immunity, allergyhttp://www.sciencedirect.com/science/article/pii/S1939455119305861 |
| spellingShingle | Bernhard F. Gibbs Basophils as Key Regulators of Allergic Inflammation and Th2-type Immunity World Allergy Organization Journal |
| title | Basophils as Key Regulators of Allergic Inflammation and Th2-type Immunity |
| title_full | Basophils as Key Regulators of Allergic Inflammation and Th2-type Immunity |
| title_fullStr | Basophils as Key Regulators of Allergic Inflammation and Th2-type Immunity |
| title_full_unstemmed | Basophils as Key Regulators of Allergic Inflammation and Th2-type Immunity |
| title_short | Basophils as Key Regulators of Allergic Inflammation and Th2-type Immunity |
| title_sort | basophils as key regulators of allergic inflammation and th2 type immunity |
| url | http://www.sciencedirect.com/science/article/pii/S1939455119305861 |
| work_keys_str_mv | AT bernhardfgibbs basophilsaskeyregulatorsofallergicinflammationandth2typeimmunity |