How sex affects the sinus rhythm heartbeat
Background: There is increasing awareness of sex-specific differences in epidemiology and pathophysiology of atrial fibrillation (AF). It is, however, unknown whether males and females differ in atrial electrophysiological properties during sinus rhythm (SR). The aim of this study was therefore to i...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-12-01
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| Series: | International Journal of Cardiology: Heart & Vasculature |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352906723001458 |
| _version_ | 1797398539414798336 |
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| author | Danny Veen Corina Schram-Serban Mathijs van Schie Frank van Schaagen Paul Knops Maryam Kavousi Yannick Taverne Natasja M.S. de Groot |
| author_facet | Danny Veen Corina Schram-Serban Mathijs van Schie Frank van Schaagen Paul Knops Maryam Kavousi Yannick Taverne Natasja M.S. de Groot |
| author_sort | Danny Veen |
| collection | DOAJ |
| description | Background: There is increasing awareness of sex-specific differences in epidemiology and pathophysiology of atrial fibrillation (AF). It is, however, unknown whether males and females differ in atrial electrophysiological properties during sinus rhythm (SR). The aim of this study was therefore to investigate sex-based (regional) differences in electrophysiological properties during SR of the right (RA) and left (LA) atrium including Bachmanns Bundle (BB) and pulmonary vein region (PVA). Methods: Intra-operative, high resolution mapping during SR was performed in 53 matched females with males (without a history of AF), to measure lines of conduction block (CB), continuous conduction delay and block (cCDCB), conduction velocities (CV), total atrial activation times (TAT), unipolar potential voltages and percentage of low voltage areas (LVA). Results: Compared to males, females have significantly 1) lower unipolar potential voltages and slower CV at both RA and BB, 2) more LVAs, CB and cCDCB lines and longer CB and cCDCB lines at the RA only (all P < 0.05). Conclusions: Electrophysiological properties of the atria during SR differ between males and females. These sex-based differences are particularly present at the RA and to a lesser degree at BB. In females, both the RA and BB contained more areas of conduction disorders and low voltage potentials. Future studies are required to investigate whether these areas play a role in sex-based differences in vulnerability to arrhythmias such as atrial fibrillation. |
| first_indexed | 2024-03-09T01:26:57Z |
| format | Article |
| id | doaj.art-0327948daaaf4ffe82bb1fee7a629a40 |
| institution | Directory Open Access Journal |
| issn | 2352-9067 |
| language | English |
| last_indexed | 2024-03-09T01:26:57Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Cardiology: Heart & Vasculature |
| spelling | doaj.art-0327948daaaf4ffe82bb1fee7a629a402023-12-10T06:16:34ZengElsevierInternational Journal of Cardiology: Heart & Vasculature2352-90672023-12-0149101314How sex affects the sinus rhythm heartbeatDanny Veen0Corina Schram-Serban1Mathijs van Schie2Frank van Schaagen3Paul Knops4Maryam Kavousi5Yannick Taverne6Natasja M.S. de Groot7Dept of Cardiology, Erasmus University Medical Center, Rotterdam, the NetherlandsDept of Cardiology, Erasmus University Medical Center, Rotterdam, the NetherlandsDept of Cardiology, Erasmus University Medical Center, Rotterdam, the NetherlandsDept of Cardio-Thoracic Surgery, Erasmus University Medical Center, Rotterdam, the NetherlandsDept of Cardiology, Erasmus University Medical Center, Rotterdam, the NetherlandsDept of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, the NetherlandsDept of Cardio-Thoracic Surgery, Erasmus University Medical Center, Rotterdam, the NetherlandsDept of Cardiology, Erasmus University Medical Center, Rotterdam, the Netherlands; Dept of Micro-electronics, Circuits and Systems, Faculty of Electrical Engineering, the Netherlands; Corresponding author at: Erasmus Medical Center, Department of Cardiology, Unit Translational Electrophysiology, EE1983, Dr. Molewaterplein 40, PO Box 2040, 3000CA Rotterdam, the Netherlands.Background: There is increasing awareness of sex-specific differences in epidemiology and pathophysiology of atrial fibrillation (AF). It is, however, unknown whether males and females differ in atrial electrophysiological properties during sinus rhythm (SR). The aim of this study was therefore to investigate sex-based (regional) differences in electrophysiological properties during SR of the right (RA) and left (LA) atrium including Bachmanns Bundle (BB) and pulmonary vein region (PVA). Methods: Intra-operative, high resolution mapping during SR was performed in 53 matched females with males (without a history of AF), to measure lines of conduction block (CB), continuous conduction delay and block (cCDCB), conduction velocities (CV), total atrial activation times (TAT), unipolar potential voltages and percentage of low voltage areas (LVA). Results: Compared to males, females have significantly 1) lower unipolar potential voltages and slower CV at both RA and BB, 2) more LVAs, CB and cCDCB lines and longer CB and cCDCB lines at the RA only (all P < 0.05). Conclusions: Electrophysiological properties of the atria during SR differ between males and females. These sex-based differences are particularly present at the RA and to a lesser degree at BB. In females, both the RA and BB contained more areas of conduction disorders and low voltage potentials. Future studies are required to investigate whether these areas play a role in sex-based differences in vulnerability to arrhythmias such as atrial fibrillation.http://www.sciencedirect.com/science/article/pii/S2352906723001458Sex differencesAtrial mappingConduction disordersElectrophysiological properties |
| spellingShingle | Danny Veen Corina Schram-Serban Mathijs van Schie Frank van Schaagen Paul Knops Maryam Kavousi Yannick Taverne Natasja M.S. de Groot How sex affects the sinus rhythm heartbeat International Journal of Cardiology: Heart & Vasculature Sex differences Atrial mapping Conduction disorders Electrophysiological properties |
| title | How sex affects the sinus rhythm heartbeat |
| title_full | How sex affects the sinus rhythm heartbeat |
| title_fullStr | How sex affects the sinus rhythm heartbeat |
| title_full_unstemmed | How sex affects the sinus rhythm heartbeat |
| title_short | How sex affects the sinus rhythm heartbeat |
| title_sort | how sex affects the sinus rhythm heartbeat |
| topic | Sex differences Atrial mapping Conduction disorders Electrophysiological properties |
| url | http://www.sciencedirect.com/science/article/pii/S2352906723001458 |
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