Lipids as Emerging Biomarkers in Neurodegenerative Diseases
Biomarkers are molecules that can be used to observe changes in an individual’s biochemical or medical status and provide information to aid diagnosis or treatment decisions. Dysregulation in lipid metabolism in the brain is a major risk factor for many neurodegenerative disorders, including frontot...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-12-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/25/1/131 |
| _version_ | 1797358705747951616 |
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| author | Justin Wei Li Chin Wong Sebastian Boland |
| author_facet | Justin Wei Li Chin Wong Sebastian Boland |
| author_sort | Justin Wei |
| collection | DOAJ |
| description | Biomarkers are molecules that can be used to observe changes in an individual’s biochemical or medical status and provide information to aid diagnosis or treatment decisions. Dysregulation in lipid metabolism in the brain is a major risk factor for many neurodegenerative disorders, including frontotemporal dementia, Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis. Thus, there is a growing interest in using lipids as biomarkers in neurodegenerative diseases, with the anionic phospholipid bis(monoacylglycerol)phosphate and (glyco-)sphingolipids being the most promising lipid classes thus far. In this review, we provide a general overview of lipid biology, provide examples of abnormal lysosomal lipid metabolism in neurodegenerative diseases, and discuss how these insights might offer novel and promising opportunities in biomarker development and therapeutic discovery. Finally, we discuss the challenges and opportunities of lipid biomarkers and biomarker panels in diagnosis, prognosis, and/or treatment response in the clinic. |
| first_indexed | 2024-03-08T15:05:55Z |
| format | Article |
| id | doaj.art-0328b039b1b14af8af40af250157012e |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-08T15:05:55Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-0328b039b1b14af8af40af250157012e2024-01-10T14:58:16ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-12-0125113110.3390/ijms25010131Lipids as Emerging Biomarkers in Neurodegenerative DiseasesJustin Wei0Li Chin Wong1Sebastian Boland2Prevail Therapeutics, a Wholly Owned Subsidiary of Eli Lilly and Company, New York, NY 10016, USAPrevail Therapeutics, a Wholly Owned Subsidiary of Eli Lilly and Company, New York, NY 10016, USAPrevail Therapeutics, a Wholly Owned Subsidiary of Eli Lilly and Company, New York, NY 10016, USABiomarkers are molecules that can be used to observe changes in an individual’s biochemical or medical status and provide information to aid diagnosis or treatment decisions. Dysregulation in lipid metabolism in the brain is a major risk factor for many neurodegenerative disorders, including frontotemporal dementia, Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis. Thus, there is a growing interest in using lipids as biomarkers in neurodegenerative diseases, with the anionic phospholipid bis(monoacylglycerol)phosphate and (glyco-)sphingolipids being the most promising lipid classes thus far. In this review, we provide a general overview of lipid biology, provide examples of abnormal lysosomal lipid metabolism in neurodegenerative diseases, and discuss how these insights might offer novel and promising opportunities in biomarker development and therapeutic discovery. Finally, we discuss the challenges and opportunities of lipid biomarkers and biomarker panels in diagnosis, prognosis, and/or treatment response in the clinic.https://www.mdpi.com/1422-0067/25/1/131lipidsbiomarkersneurodegenerative diseasesbis(monoacylglycero)phosphate (BMP)gangliosidessphingolipids |
| spellingShingle | Justin Wei Li Chin Wong Sebastian Boland Lipids as Emerging Biomarkers in Neurodegenerative Diseases International Journal of Molecular Sciences lipids biomarkers neurodegenerative diseases bis(monoacylglycero)phosphate (BMP) gangliosides sphingolipids |
| title | Lipids as Emerging Biomarkers in Neurodegenerative Diseases |
| title_full | Lipids as Emerging Biomarkers in Neurodegenerative Diseases |
| title_fullStr | Lipids as Emerging Biomarkers in Neurodegenerative Diseases |
| title_full_unstemmed | Lipids as Emerging Biomarkers in Neurodegenerative Diseases |
| title_short | Lipids as Emerging Biomarkers in Neurodegenerative Diseases |
| title_sort | lipids as emerging biomarkers in neurodegenerative diseases |
| topic | lipids biomarkers neurodegenerative diseases bis(monoacylglycero)phosphate (BMP) gangliosides sphingolipids |
| url | https://www.mdpi.com/1422-0067/25/1/131 |
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