The prognostic significance of immunophenotypes in canine malignant mammary tumors
ABSTRACT Canine malignant mammary neoplasms (CMMN) exhibit behavioral variability with the patient survival time depending on several prognostic factors. In the present study, 134 CMMN were selected and different immunophenotypes and their associations with clinical and pathological parameters were...
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Universidade Federal de Minas Gerais
2022-05-01
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| Series: | Arquivo Brasileiro de Medicina Veterinária e Zootecnia |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352022000200299&lng=en&tlng=en |
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| author | F.C. Nunes A.C. Bertagnolli G.E. Lavalle T.L. Silveira D. Balabram G.D. Cassali |
| author_facet | F.C. Nunes A.C. Bertagnolli G.E. Lavalle T.L. Silveira D. Balabram G.D. Cassali |
| author_sort | F.C. Nunes |
| collection | DOAJ |
| description | ABSTRACT Canine malignant mammary neoplasms (CMMN) exhibit behavioral variability with the patient survival time depending on several prognostic factors. In the present study, 134 CMMN were selected and different immunophenotypes and their associations with clinical and pathological parameters were identified. The tumors were classified as follows: 46% of luminal B HER2-, 34% of luminal A, 13% of triple-negative, and 7% of luminal B HER2+. Shorter specific survival time were associated with larger tumor sizes (>3.0 cm, HR=1.94; P=0.0209), lymph node metastasis or distant metastasis (HR= 2.82; P <.0001), more aggressive histological types (HR= 7.15, P<0.0001), higher histological grades (HR= 12.97 P=0.011), angiolymphatic invasion (HR=4.68, P<0.0001) and luminal B HER2 - (HR= 3.27, P<0.0001) and luminal B HER2 + (HR= 7.14 P<0.0001) immunophenotypes. In patients with lymph nodal metastasis, shorter survival times were associated with luminal immunophenotype B HER2 + (P=0.003). However, in patients without metastasis, an increased risk of death was associated with the aggressive histological type. In conclusion, the classification in our study allowed us to identify subtypes with different prognoses in canine malignant mammary tumors. Factors such as clinical stage, histological type, luminal B HER2+ subtype, and angiolymphatic invasion were the most important prognostic factors. |
| first_indexed | 2024-04-12T17:02:01Z |
| format | Article |
| id | doaj.art-03292a13c2964723818fd1ac8300698d |
| institution | Directory Open Access Journal |
| issn | 1678-4162 |
| language | English |
| last_indexed | 2024-04-12T17:02:01Z |
| publishDate | 2022-05-01 |
| publisher | Universidade Federal de Minas Gerais |
| record_format | Article |
| series | Arquivo Brasileiro de Medicina Veterinária e Zootecnia |
| spelling | doaj.art-03292a13c2964723818fd1ac8300698d2022-12-22T03:24:03ZengUniversidade Federal de Minas GeraisArquivo Brasileiro de Medicina Veterinária e Zootecnia1678-41622022-05-0174229930910.1590/1678-4162-12273The prognostic significance of immunophenotypes in canine malignant mammary tumorsF.C. Nuneshttps://orcid.org/0000-0002-5286-5749A.C. Bertagnollihttps://orcid.org/0000-0002-4956-2085G.E. Lavallehttps://orcid.org/0000-0002-2701-9954T.L. Silveirahttps://orcid.org/0000-0001-7090-6535D. Balabramhttps://orcid.org/0000-0003-3077-7526G.D. Cassalihttps://orcid.org/0000-0002-5650-6743ABSTRACT Canine malignant mammary neoplasms (CMMN) exhibit behavioral variability with the patient survival time depending on several prognostic factors. In the present study, 134 CMMN were selected and different immunophenotypes and their associations with clinical and pathological parameters were identified. The tumors were classified as follows: 46% of luminal B HER2-, 34% of luminal A, 13% of triple-negative, and 7% of luminal B HER2+. Shorter specific survival time were associated with larger tumor sizes (>3.0 cm, HR=1.94; P=0.0209), lymph node metastasis or distant metastasis (HR= 2.82; P <.0001), more aggressive histological types (HR= 7.15, P<0.0001), higher histological grades (HR= 12.97 P=0.011), angiolymphatic invasion (HR=4.68, P<0.0001) and luminal B HER2 - (HR= 3.27, P<0.0001) and luminal B HER2 + (HR= 7.14 P<0.0001) immunophenotypes. In patients with lymph nodal metastasis, shorter survival times were associated with luminal immunophenotype B HER2 + (P=0.003). However, in patients without metastasis, an increased risk of death was associated with the aggressive histological type. In conclusion, the classification in our study allowed us to identify subtypes with different prognoses in canine malignant mammary tumors. Factors such as clinical stage, histological type, luminal B HER2+ subtype, and angiolymphatic invasion were the most important prognostic factors.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352022000200299&lng=en&tlng=encarcinomamammary glandluminaltriple-negative |
| spellingShingle | F.C. Nunes A.C. Bertagnolli G.E. Lavalle T.L. Silveira D. Balabram G.D. Cassali The prognostic significance of immunophenotypes in canine malignant mammary tumors Arquivo Brasileiro de Medicina Veterinária e Zootecnia carcinoma mammary gland luminal triple-negative |
| title | The prognostic significance of immunophenotypes in canine malignant mammary tumors |
| title_full | The prognostic significance of immunophenotypes in canine malignant mammary tumors |
| title_fullStr | The prognostic significance of immunophenotypes in canine malignant mammary tumors |
| title_full_unstemmed | The prognostic significance of immunophenotypes in canine malignant mammary tumors |
| title_short | The prognostic significance of immunophenotypes in canine malignant mammary tumors |
| title_sort | prognostic significance of immunophenotypes in canine malignant mammary tumors |
| topic | carcinoma mammary gland luminal triple-negative |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352022000200299&lng=en&tlng=en |
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