Therapeutic effect of a novel histone deacetylase 6 inhibitor, CKD-L, on collagen-induced arthritis in vivo and regulatory T cells in rheumatoid arthritis in vitro

Therapeutic effect of a novel histone deacetylase 6 inhibitor, CKD-L, on collagen-induced arthritis in vivo and regulatory T cells in rheumatoid arthritis in vitro

Abstract Background Histone deacetylase (HDAC) inhibitor has recently been reported to have a therapeutic effect as an anti-inflammatory agent in collagen-induced arthritis (CIA). We investigated the therapeutic effect of a new selective HDAC6 inhibitor, CKD-L, compared to ITF 2357 or Tubastatin A o...

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Bibliographic Details
Main Authors: Bo Ram Oh, Dong-hyeon Suh, Daekwon Bae, Nina Ha, Young Il Choi, Hyun Jung Yoo, Jin Kyun Park, Eun Young Lee, Eun Bong Lee, Yeong Wook Song
Format: Article
Language:English
Published: BMC 2017-07-01
Series:Arthritis Research & Therapy
Subjects:
Histone deacetylase 6
Histone deacetylase inhibitor
Rheumatoid arthritis
Collagen-induced arthritis
Regulatory T cell
Online Access:http://link.springer.com/article/10.1186/s13075-017-1357-2

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