Precision Nanomedicine Vol. 2, Issue 4 Table of Contents
Protein Binding Effects of Dopamine Coated Titanium Dioxide Shell Nanoparticles, Woloschak et al., [Precis. Nanomed. 2019 July;2(4):393-438](https://precisionnanomedicine.com/article/10699-protein-binding-effects-of-dopamine-coated-titanium-dioxide-shell-nanoparticles) ABSTRACT: Non-targeted nanopa...
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| Format: | Article |
| Language: | English |
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Andover House Inc.
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| Series: | Precision Nanomedicine |
| Online Access: | http://prnano.scholasticahq.com/article/11820-precision-nanomedicine-vol-2-issue-4-table-of-contents.pdf |
| _version_ | 1811262516582416384 |
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| author | Lajos P Balogh |
| author_facet | Lajos P Balogh |
| author_sort | Lajos P Balogh |
| collection | DOAJ |
| description | Protein Binding Effects of Dopamine Coated Titanium Dioxide Shell Nanoparticles, Woloschak et al.,
[Precis. Nanomed. 2019 July;2(4):393-438](https://precisionnanomedicine.com/article/10699-protein-binding-effects-of-dopamine-coated-titanium-dioxide-shell-nanoparticles)
ABSTRACT: Non-targeted nanoparticles are capable of entering cells, passing through different subcellular compartments and accumulating on their surface a protein corona that changes over time. In this study, we used metal oxide nanoparticles with iron-oxide core covered with titanium dioxide shell (Fe3O4@TiO2), with a single layer of covalently bound dopamine covering the nanoparticle surface. Mixing nanoparticles with cellular protein isolates showed that these nanoparticles can form complexes with numerous cellular proteins. The addition of non-toxic quantities of nanoparticles to HeLa cell culture resulted in their non-specific uptake and accumulation of protein corona on nanoparticle surface. TfRC, Hsp90 and PARP were followed as representative protein components of nanoparticle corona; each protein bound to nanoparticles with different affinity. The presence of nanoparticles in cells also mildly modulated gene expression on the level of mRNA. In conclusion, cells exposed to non-targeted nanoparticles show subtle but numerous changes that are consistent from one experiment to another.
Application of microfluidic systems for neural differentiation of cells, Atyabi et el.
[Precis. Nanomed. 2019 Oct;2(4):370-381](https://precisionnanomedicine.com/article/9973-application-of-microfluidic-systems-for-neural-differentiation-of-cells)
POTENTIAL CLINICAL SIGNIFICANCE.
ABSTRACT: Neural differentiation of stem cells is an important issue in the development of the central nervous system. Different methods such as chemical stimulation with small molecules, scaffolds, and microRNA can be used for inducing the differentiation of neural stem cells. However, microfluidic systems with the potential to induce neuronal differentiation have established their reputation in the field of regenerative medicine. Organization of the microfluidic system represents a novel model that mimics the physiologic microenvironment of cells among other two- and three-dimensional cell culture systems. The microfluidic system has a patterned and well-organized structure that can be combined with other differentiation techniques to provide optimal conditions for neuronal differentiation of stem cells. In this review, different methods for effective differentiation of stem cells to neuronal cells are summarized. The efficacy of microfluidic systems in promoting neuronal differentiation is also addressed.
Oxidative Toxicity in Diabetes Mellitus: The Role of Nanoparticles and Future Therapeutic Strategies, Rajnbar et al.
[Precis. Nanomed. 2019 Oct;2(4):382-392](https://precisionnanomedicine.com/article/10592-oxidative-toxicity-in-diabetes-mellitus-role-of-nanoparticles-and-future-therapeutic-strategies)
POTENTIAL CLINICAL SIGNIFICANCE
ABSTRACT: Diabetes mellitus is one of the most common chronic medical conditions in the world. Increasing evidence suggests that chronic hyperglycemia can cause excessive production of free radicals, particularly reactive oxygen species (ROS). Free radicals play important roles in tissue damage in diabetes. The relationship between exposure to nanoparticles (NPs) and diabetes has been reported in many previous studies. Evaluation of the potential benefits and toxic effects of NPs on diabetic disorders is of importance. This review highlights studies on the relationship between NPs and oxidative stress (OS) as well as the possible mechanisms in diabetic animal models and humans. |
| first_indexed | 2024-04-12T19:28:03Z |
| format | Article |
| id | doaj.art-032aa2c515e64975b4b7316900c5cf6f |
| institution | Directory Open Access Journal |
| issn | 2639-9431 |
| language | English |
| last_indexed | 2024-04-12T19:28:03Z |
| publisher | Andover House Inc. |
| record_format | Article |
| series | Precision Nanomedicine |
| spelling | doaj.art-032aa2c515e64975b4b7316900c5cf6f2022-12-22T03:19:26ZengAndover House Inc.Precision Nanomedicine2639-9431Precision Nanomedicine Vol. 2, Issue 4 Table of ContentsLajos P BaloghProtein Binding Effects of Dopamine Coated Titanium Dioxide Shell Nanoparticles, Woloschak et al., [Precis. Nanomed. 2019 July;2(4):393-438](https://precisionnanomedicine.com/article/10699-protein-binding-effects-of-dopamine-coated-titanium-dioxide-shell-nanoparticles) ABSTRACT: Non-targeted nanoparticles are capable of entering cells, passing through different subcellular compartments and accumulating on their surface a protein corona that changes over time. In this study, we used metal oxide nanoparticles with iron-oxide core covered with titanium dioxide shell (Fe3O4@TiO2), with a single layer of covalently bound dopamine covering the nanoparticle surface. Mixing nanoparticles with cellular protein isolates showed that these nanoparticles can form complexes with numerous cellular proteins. The addition of non-toxic quantities of nanoparticles to HeLa cell culture resulted in their non-specific uptake and accumulation of protein corona on nanoparticle surface. TfRC, Hsp90 and PARP were followed as representative protein components of nanoparticle corona; each protein bound to nanoparticles with different affinity. The presence of nanoparticles in cells also mildly modulated gene expression on the level of mRNA. In conclusion, cells exposed to non-targeted nanoparticles show subtle but numerous changes that are consistent from one experiment to another. Application of microfluidic systems for neural differentiation of cells, Atyabi et el. [Precis. Nanomed. 2019 Oct;2(4):370-381](https://precisionnanomedicine.com/article/9973-application-of-microfluidic-systems-for-neural-differentiation-of-cells) POTENTIAL CLINICAL SIGNIFICANCE. ABSTRACT: Neural differentiation of stem cells is an important issue in the development of the central nervous system. Different methods such as chemical stimulation with small molecules, scaffolds, and microRNA can be used for inducing the differentiation of neural stem cells. However, microfluidic systems with the potential to induce neuronal differentiation have established their reputation in the field of regenerative medicine. Organization of the microfluidic system represents a novel model that mimics the physiologic microenvironment of cells among other two- and three-dimensional cell culture systems. The microfluidic system has a patterned and well-organized structure that can be combined with other differentiation techniques to provide optimal conditions for neuronal differentiation of stem cells. In this review, different methods for effective differentiation of stem cells to neuronal cells are summarized. The efficacy of microfluidic systems in promoting neuronal differentiation is also addressed. Oxidative Toxicity in Diabetes Mellitus: The Role of Nanoparticles and Future Therapeutic Strategies, Rajnbar et al. [Precis. Nanomed. 2019 Oct;2(4):382-392](https://precisionnanomedicine.com/article/10592-oxidative-toxicity-in-diabetes-mellitus-role-of-nanoparticles-and-future-therapeutic-strategies) POTENTIAL CLINICAL SIGNIFICANCE ABSTRACT: Diabetes mellitus is one of the most common chronic medical conditions in the world. Increasing evidence suggests that chronic hyperglycemia can cause excessive production of free radicals, particularly reactive oxygen species (ROS). Free radicals play important roles in tissue damage in diabetes. The relationship between exposure to nanoparticles (NPs) and diabetes has been reported in many previous studies. Evaluation of the potential benefits and toxic effects of NPs on diabetic disorders is of importance. This review highlights studies on the relationship between NPs and oxidative stress (OS) as well as the possible mechanisms in diabetic animal models and humans.http://prnano.scholasticahq.com/article/11820-precision-nanomedicine-vol-2-issue-4-table-of-contents.pdf |
| spellingShingle | Lajos P Balogh Precision Nanomedicine Vol. 2, Issue 4 Table of Contents Precision Nanomedicine |
| title | Precision Nanomedicine Vol. 2, Issue 4 Table of Contents |
| title_full | Precision Nanomedicine Vol. 2, Issue 4 Table of Contents |
| title_fullStr | Precision Nanomedicine Vol. 2, Issue 4 Table of Contents |
| title_full_unstemmed | Precision Nanomedicine Vol. 2, Issue 4 Table of Contents |
| title_short | Precision Nanomedicine Vol. 2, Issue 4 Table of Contents |
| title_sort | precision nanomedicine vol 2 issue 4 table of contents |
| url | http://prnano.scholasticahq.com/article/11820-precision-nanomedicine-vol-2-issue-4-table-of-contents.pdf |
| work_keys_str_mv | AT lajospbalogh precisionnanomedicinevol2issue4tableofcontents |