Engineered Extracellular Vesicles from Human Skin Cells Induce Pro‐β‐Cell Conversions in Pancreatic Ductal Cells

Engineered Extracellular Vesicles from Human Skin Cells Induce Pro‐β‐Cell Conversions in Pancreatic Ductal Cells

Direct nuclear reprogramming has the potential to enable the development of β cell replacement therapies for diabetes that do not require the use of progenitor/stem cell populations. However, despite their promise, current approaches to β cell‐directed reprogramming rely heavily on the use of viral...

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Bibliographic Details
Main Authors: Lilibeth Ortega-Pineda, Maria Angelica Rincon-Benavides, Tatiana Z. Cuellar-Gaviria, Mia Kordowski, Elizabeth Guilfoyle, Amrita Lakshmi Anaparthi, Luke R. Lemmerman, William Lawrence, Jill L. Buss, Binbin Deng, Britani N. Blackstone, Ana Salazar-Puerta, David W. McComb, Heather Powell, Daniel Gallego-Perez, Natalia Higuita-Castro
Format: Article
Language:English
Published: Wiley-VCH 2023-10-01
Series:Advanced NanoBiomed Research
Subjects:
cell reprogramming
diabetes
engineered EVs
nonviral gene delivery
β cell replacement therapies
Online Access:https://doi.org/10.1002/anbr.202200173

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