Tanshinone IIA inhibits AGEs-induced proliferation and migration of cultured vascular smooth muscle cells by suppressing ERK1/2 MAPK signaling
Objective(s): Vascular smooth muscle cells (VSMCs) play a key role in the pathogenesis of diabetic vascular disease. Our current study sought to explore the effects of tanshinone IIA on the proliferation and migration of VSMCs induced by advanced glycation end products (AGEs). Materials and Methods:...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2018-01-01
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| Series: | Iranian Journal of Basic Medical Sciences |
| Subjects: | |
| Online Access: | http://ijbms.mums.ac.ir/article_9925_28e01b97026f81ad151815134a0a228d.pdf |
| _version_ | 1818370245027430400 |
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| author | Ming Lu Ying Luo Pengfei Hu Liping Dou Shuwei Huang |
| author_facet | Ming Lu Ying Luo Pengfei Hu Liping Dou Shuwei Huang |
| author_sort | Ming Lu |
| collection | DOAJ |
| description | Objective(s): Vascular smooth muscle cells (VSMCs) play a key role in the pathogenesis of diabetic vascular disease. Our current study sought to explore the effects of tanshinone IIA on the proliferation and migration of VSMCs induced by advanced glycation end products (AGEs). Materials and Methods: In this study, we examined the effects of tanshinone IIA by cell proliferation assay and cell migration assay. And we explored the underlying mechanism by Western blotting. Results: AGEs significantly induced the proliferation and migration of VSMCs, but treatment with tanshinone IIA attenuated these effects. AGEs could increase the activity of the ERK1/2 and p38 pathways but not the JNK pathway. Treatment with tanshinone IIA inhibited the AGEs-induced activation of the ERK1/2 pathway but not the p38 pathway. Conclusion: Tanshinone IIA inhibits AGEs-induced proliferation and migration of VSMCs by suppressing the ERK1/2 MAPK signaling pathway. |
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| format | Article |
| id | doaj.art-032c0a739caf40c9b9fc00f918d059f8 |
| institution | Directory Open Access Journal |
| issn | 2008-3866 2008-3874 |
| language | English |
| last_indexed | 2024-12-13T23:36:40Z |
| publishDate | 2018-01-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Basic Medical Sciences |
| spelling | doaj.art-032c0a739caf40c9b9fc00f918d059f82022-12-21T23:27:17ZengMashhad University of Medical SciencesIranian Journal of Basic Medical Sciences2008-38662008-38742018-01-01211838810.22038/ijbms.2017.20100.52769925Tanshinone IIA inhibits AGEs-induced proliferation and migration of cultured vascular smooth muscle cells by suppressing ERK1/2 MAPK signalingMing Lu0Ying Luo1Pengfei Hu2Liping Dou3Shuwei Huang4Department of Cardiology, the Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China, 310005Department of Cardiology, the Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China, 310005Department of Cardiology, the Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China, 310005Department of Cardiology, the Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China, 310005Department of Cardiology, the Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China, 310005Objective(s): Vascular smooth muscle cells (VSMCs) play a key role in the pathogenesis of diabetic vascular disease. Our current study sought to explore the effects of tanshinone IIA on the proliferation and migration of VSMCs induced by advanced glycation end products (AGEs). Materials and Methods: In this study, we examined the effects of tanshinone IIA by cell proliferation assay and cell migration assay. And we explored the underlying mechanism by Western blotting. Results: AGEs significantly induced the proliferation and migration of VSMCs, but treatment with tanshinone IIA attenuated these effects. AGEs could increase the activity of the ERK1/2 and p38 pathways but not the JNK pathway. Treatment with tanshinone IIA inhibited the AGEs-induced activation of the ERK1/2 pathway but not the p38 pathway. Conclusion: Tanshinone IIA inhibits AGEs-induced proliferation and migration of VSMCs by suppressing the ERK1/2 MAPK signaling pathway.http://ijbms.mums.ac.ir/article_9925_28e01b97026f81ad151815134a0a228d.pdfAdvancedERK1/2Glycation end productsJNKP38Tanshinone IIAVascular Smooth Muscle |
| spellingShingle | Ming Lu Ying Luo Pengfei Hu Liping Dou Shuwei Huang Tanshinone IIA inhibits AGEs-induced proliferation and migration of cultured vascular smooth muscle cells by suppressing ERK1/2 MAPK signaling Iranian Journal of Basic Medical Sciences Advanced ERK1/2 Glycation end products JNK P38 Tanshinone IIA Vascular Smooth Muscle |
| title | Tanshinone IIA inhibits AGEs-induced proliferation and migration of cultured vascular smooth muscle cells by suppressing ERK1/2 MAPK signaling |
| title_full | Tanshinone IIA inhibits AGEs-induced proliferation and migration of cultured vascular smooth muscle cells by suppressing ERK1/2 MAPK signaling |
| title_fullStr | Tanshinone IIA inhibits AGEs-induced proliferation and migration of cultured vascular smooth muscle cells by suppressing ERK1/2 MAPK signaling |
| title_full_unstemmed | Tanshinone IIA inhibits AGEs-induced proliferation and migration of cultured vascular smooth muscle cells by suppressing ERK1/2 MAPK signaling |
| title_short | Tanshinone IIA inhibits AGEs-induced proliferation and migration of cultured vascular smooth muscle cells by suppressing ERK1/2 MAPK signaling |
| title_sort | tanshinone iia inhibits ages induced proliferation and migration of cultured vascular smooth muscle cells by suppressing erk1 2 mapk signaling |
| topic | Advanced ERK1/2 Glycation end products JNK P38 Tanshinone IIA Vascular Smooth Muscle |
| url | http://ijbms.mums.ac.ir/article_9925_28e01b97026f81ad151815134a0a228d.pdf |
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