Tanshinone IIA inhibits AGEs-induced proliferation and migration of cultured vascular smooth muscle cells by suppressing ERK1/2 MAPK signaling

Tanshinone IIA inhibits AGEs-induced proliferation and migration of cultured vascular smooth muscle cells by suppressing ERK1/2 MAPK signaling

Objective(s): Vascular smooth muscle cells (VSMCs) play a key role in the pathogenesis of diabetic vascular disease. Our current study sought to explore the effects of tanshinone IIA on the proliferation and migration of VSMCs induced by advanced glycation end products (AGEs). Materials and Methods:...

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Bibliographic Details
Main Authors: Ming Lu, Ying Luo, Pengfei Hu, Liping Dou, Shuwei Huang
Format: Article
Language:English
Published: Mashhad University of Medical Sciences 2018-01-01
Series:Iranian Journal of Basic Medical Sciences
Subjects:
Advanced
ERK1/2
Glycation end products
JNK
P38
Tanshinone IIA
Vascular Smooth Muscle
Online Access:http://ijbms.mums.ac.ir/article_9925_28e01b97026f81ad151815134a0a228d.pdf

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