Does clozapine really affect bone mineral density? An experimental study
Abstract Purpose The aim of this study was to investigate the effect of clozapine use on bone tissue by applying computerized tomography, dual-energy X-ray absorptiometry, and histological and biomechanical analyses in an experimental rat model. Methods Sixteen female Wistar Albino rats were include...
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| Format: | Article |
| Language: | English |
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BMC
2021-09-01
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| Series: | Journal of Orthopaedic Surgery and Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13018-021-02695-w |
| _version_ | 1818012792526995456 |
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| author | Bahattin Kerem Aydin Selim Safali Memduha Aydin Umran Egilmez Hakan Cebeci Murat Çelik Ummuhan Abdulrezzak |
| author_facet | Bahattin Kerem Aydin Selim Safali Memduha Aydin Umran Egilmez Hakan Cebeci Murat Çelik Ummuhan Abdulrezzak |
| author_sort | Bahattin Kerem Aydin |
| collection | DOAJ |
| description | Abstract Purpose The aim of this study was to investigate the effect of clozapine use on bone tissue by applying computerized tomography, dual-energy X-ray absorptiometry, and histological and biomechanical analyses in an experimental rat model. Methods Sixteen female Wistar Albino rats were included in this study. These animals were divided into two groups: the control group and the clozapine group. The animals in the clozapine group received 10 mg/kg clozapine, and the animals in the control group received tap water by oral gavage daily for 28 days. After sacrification, the femurs of the rats were used for radiologic, histologic, dual-energy X-ray absorptiometry, and biomechanical evaluations. Results Although the mean values of the clozapine group were higher in terms of histological, bone mineral density, and biomechanical evaluations, the statistical analyses were not significantly different. Conclusion Clozapine use did not affect bone density in the rats. Clozapine can be the preferred treatment for patients with schizophrenia to avoid osteoporosis. It will be necessary to conduct further long-term follow-up and controlled studies in animals and humans to confirm these findings. |
| first_indexed | 2024-04-14T06:24:49Z |
| format | Article |
| id | doaj.art-032f08251d234df99b6916f583790bd3 |
| institution | Directory Open Access Journal |
| issn | 1749-799X |
| language | English |
| last_indexed | 2024-04-14T06:24:49Z |
| publishDate | 2021-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Orthopaedic Surgery and Research |
| spelling | doaj.art-032f08251d234df99b6916f583790bd32022-12-22T02:07:52ZengBMCJournal of Orthopaedic Surgery and Research1749-799X2021-09-011611510.1186/s13018-021-02695-wDoes clozapine really affect bone mineral density? An experimental studyBahattin Kerem Aydin0Selim Safali1Memduha Aydin2Umran Egilmez3Hakan Cebeci4Murat Çelik5Ummuhan Abdulrezzak6Faculty of Medicine, Department of Orthopedics and Traumatology, Selcuk UniversityFaculty of Medicine, Department of Orthopedics and Traumatology, Selcuk UniversityFaculty of Medicine, Department of Psychiatry, Selcuk UniversityFaculty of Medicine, Department of Psychiatry, Selcuk UniversityFaculty of Medicine, Department of Radiology, Selcuk UniversityFaculty of Medicine, Department of Pathology, Selcuk UniversityFaculty of Medicine, Department of Nuclear Medicine, Erciyes UniversityAbstract Purpose The aim of this study was to investigate the effect of clozapine use on bone tissue by applying computerized tomography, dual-energy X-ray absorptiometry, and histological and biomechanical analyses in an experimental rat model. Methods Sixteen female Wistar Albino rats were included in this study. These animals were divided into two groups: the control group and the clozapine group. The animals in the clozapine group received 10 mg/kg clozapine, and the animals in the control group received tap water by oral gavage daily for 28 days. After sacrification, the femurs of the rats were used for radiologic, histologic, dual-energy X-ray absorptiometry, and biomechanical evaluations. Results Although the mean values of the clozapine group were higher in terms of histological, bone mineral density, and biomechanical evaluations, the statistical analyses were not significantly different. Conclusion Clozapine use did not affect bone density in the rats. Clozapine can be the preferred treatment for patients with schizophrenia to avoid osteoporosis. It will be necessary to conduct further long-term follow-up and controlled studies in animals and humans to confirm these findings.https://doi.org/10.1186/s13018-021-02695-wOsteoporosisSchizophreniaRatBone mineral densityClozapine |
| spellingShingle | Bahattin Kerem Aydin Selim Safali Memduha Aydin Umran Egilmez Hakan Cebeci Murat Çelik Ummuhan Abdulrezzak Does clozapine really affect bone mineral density? An experimental study Journal of Orthopaedic Surgery and Research Osteoporosis Schizophrenia Rat Bone mineral density Clozapine |
| title | Does clozapine really affect bone mineral density? An experimental study |
| title_full | Does clozapine really affect bone mineral density? An experimental study |
| title_fullStr | Does clozapine really affect bone mineral density? An experimental study |
| title_full_unstemmed | Does clozapine really affect bone mineral density? An experimental study |
| title_short | Does clozapine really affect bone mineral density? An experimental study |
| title_sort | does clozapine really affect bone mineral density an experimental study |
| topic | Osteoporosis Schizophrenia Rat Bone mineral density Clozapine |
| url | https://doi.org/10.1186/s13018-021-02695-w |
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