Pulmonary AL- amyloidosis masquerading as lung malignancy in an Australian Indigenous patient with Sjogren's syndrome
Amyloidosis is a heterogeneous group of disorders characterized by misfolding of extracellular proteins. Pulmonary amyloidosis secondary to Sjogren's syndrome (SS) is rare and to the best our knowledge has not been described in indigenous population. There is also minimal information on its cli...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2019-01-01
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| Series: | Respiratory Medicine Case Reports |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213007118303277 |
| _version_ | 1818061281829060608 |
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| author | Subash Heraganahally Madeline Digges Madeleine Haygarth Kosala Liyanaarachchi Akash Kalro Sumit Mehra |
| author_facet | Subash Heraganahally Madeline Digges Madeleine Haygarth Kosala Liyanaarachchi Akash Kalro Sumit Mehra |
| author_sort | Subash Heraganahally |
| collection | DOAJ |
| description | Amyloidosis is a heterogeneous group of disorders characterized by misfolding of extracellular proteins. Pulmonary amyloidosis secondary to Sjogren's syndrome (SS) is rare and to the best our knowledge has not been described in indigenous population. There is also minimal information on its clinical and radiological features. We' describe here 52-year-old Australian Indigenous women with underlying Sjogren's syndrome who was initially suspected to have a metastatic lung cancer with FGD avid lung nodule on PET scan. However, wedge resection of the nodule demonstrated eosinophilic homogenous material that demonstrated apple-green birefringence under polarized light after staining with Congo red with immunohistochemistry pattern in keeping with AL amyloidosis. Keywords: Sjogren's syndrome, Amyloidosis, Lung nodule, Pulmonary cysts, Indigenous |
| first_indexed | 2024-12-10T13:45:50Z |
| format | Article |
| id | doaj.art-032fb60da18a4099910714ac0ef6bb5e |
| institution | Directory Open Access Journal |
| issn | 2213-0071 |
| language | English |
| last_indexed | 2024-12-10T13:45:50Z |
| publishDate | 2019-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Respiratory Medicine Case Reports |
| spelling | doaj.art-032fb60da18a4099910714ac0ef6bb5e2022-12-22T01:46:24ZengElsevierRespiratory Medicine Case Reports2213-00712019-01-01269497Pulmonary AL- amyloidosis masquerading as lung malignancy in an Australian Indigenous patient with Sjogren's syndromeSubash Heraganahally0Madeline Digges1Madeleine Haygarth2Kosala Liyanaarachchi3Akash Kalro4Sumit Mehra5Department of Respiratory and Sleep Medicine, Royal Darwin Hospital, Darwin, Australia; Flinders University, Adelaide, South Australia, Australia; Corresponding author. Royal Darwin Hospital, Tiwi, NT, Australia.Department of Respiratory and Sleep Medicine, Royal Darwin Hospital, Darwin, Australia; Flinders University, Adelaide, South Australia, AustraliaDepartment of Respiratory and Sleep Medicine, Royal Darwin Hospital, Darwin, AustraliaDepartment of Anatomical Pathology, Royal Darwin Hospital, Darwin, AustraliaDepartment of Haematology, Royal Darwin Hospital, Darwin, AustraliaDepartment of Respiratory and Sleep Medicine, Flinders Medical centre and Flinders University, Adelaide, South Australia, AustraliaAmyloidosis is a heterogeneous group of disorders characterized by misfolding of extracellular proteins. Pulmonary amyloidosis secondary to Sjogren's syndrome (SS) is rare and to the best our knowledge has not been described in indigenous population. There is also minimal information on its clinical and radiological features. We' describe here 52-year-old Australian Indigenous women with underlying Sjogren's syndrome who was initially suspected to have a metastatic lung cancer with FGD avid lung nodule on PET scan. However, wedge resection of the nodule demonstrated eosinophilic homogenous material that demonstrated apple-green birefringence under polarized light after staining with Congo red with immunohistochemistry pattern in keeping with AL amyloidosis. Keywords: Sjogren's syndrome, Amyloidosis, Lung nodule, Pulmonary cysts, Indigenoushttp://www.sciencedirect.com/science/article/pii/S2213007118303277 |
| spellingShingle | Subash Heraganahally Madeline Digges Madeleine Haygarth Kosala Liyanaarachchi Akash Kalro Sumit Mehra Pulmonary AL- amyloidosis masquerading as lung malignancy in an Australian Indigenous patient with Sjogren's syndrome Respiratory Medicine Case Reports |
| title | Pulmonary AL- amyloidosis masquerading as lung malignancy in an Australian Indigenous patient with Sjogren's syndrome |
| title_full | Pulmonary AL- amyloidosis masquerading as lung malignancy in an Australian Indigenous patient with Sjogren's syndrome |
| title_fullStr | Pulmonary AL- amyloidosis masquerading as lung malignancy in an Australian Indigenous patient with Sjogren's syndrome |
| title_full_unstemmed | Pulmonary AL- amyloidosis masquerading as lung malignancy in an Australian Indigenous patient with Sjogren's syndrome |
| title_short | Pulmonary AL- amyloidosis masquerading as lung malignancy in an Australian Indigenous patient with Sjogren's syndrome |
| title_sort | pulmonary al amyloidosis masquerading as lung malignancy in an australian indigenous patient with sjogren s syndrome |
| url | http://www.sciencedirect.com/science/article/pii/S2213007118303277 |
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